Search Results - "SPIERS, P"

The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases by Rietz, A, Spiers, JP

“…The MMPs and their inhibitors [tissue inhibitor of MMPs (TIMPs) ] form the mainstay of extracellular matrix homeostasis. They are expressed in response to…”
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St John's Wort increases expression of P‐glycoprotein: Implications for drug interactions by Hennessy, M., Kelleher, D., Spiers, J. P., Barry, M., Kavanagh, P., Back, D., Mulcahy, F., Feely, J.

“…Aims  St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs…”
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Preclinical prediction of Alzheimer's disease using SPECT by JOHNSON, K. A, JONES, K, HOLMAN, B. L, BECKER, J. A, SPIERS, P. A, SATLIN, A, ALBERT, M. S

“…Regional cerebral perfusion measured by single photon emission computed tomography (SPECT) was examined as a preclinical predictor of the development of…”
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Collagen type-I degradation is related to arterial stiffness in hypertensive and normotensive subjects by MCNULTY, M, MAHMUD, A, SPIERS, P, FEELY, J

“…Although arterial stiffness is an independent cardiovascular risk factor associated with both aging and hypertension, relatively little is known regarding the…”
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Okadaic acid induces matrix metalloproteinase‐9 expression in fibroblasts: crosstalk between protein phosphatase inhibition and β‐adrenoceptor signalling by Rietz, A, Volkov, Y, Davies, A, Hennessy, M, Spiers, JP

“…BACKGROUND AND PURPOSE Interactions between protein phosphatase inhibition and matrix metalloproteinase (MMP)‐9 expression have implications for tissue…”
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Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension by ZHOU, S, FEELY, J, SPIERS, J. P, MAHMUD, A

“…Arterial stiffness is an independent predictor of cardiovascular events in a hypertensive population. Serum levels of matrix metalloproteinase (MMP)-9 are…”
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Regulation of the phosphoprotein phosphatase 2A system and its modulation during oxidative stress: A potential therapeutic target? by Elgenaidi, I.S., Spiers, J.P.

“…Phosphoprotein phosphatases are of growing interest in the pathophysiology of many diseases and are often the neglected partner of protein kinases. One family…”
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Differential interactions of antiretroviral agents with LXR, ER and GR nuclear receptors: potential contributing factors to adverse events by Svärd, J, Blanco, F, Nevin, D, Fayne, D, Mulcahy, F, Hennessy, M, Spiers, J P

“…Background and Purpose Antiretroviral (ARV) drugs activate pregnane X receptors and constitutive androstane receptors, increasing the risk of drug interactions…”
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Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion by Ward, M P, Spiers, J P

“…Background and Purpose A hallmark of tumour invasion is breakdown of the extracellular matrix due to dysregulation of the matrix metalloproteinase (MMP)…”
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Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches by Gong, K Z, Song, G, Spiers, J P, Kelso, E J, Zhang, Z G

“…Despite extensive research and novel treatments, chronic heart failure (CHF) remains a cause of high morbidity and mortality. Mounting evidence suggested that…”
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A primer on the mechanics of P-glycoprotein the multidrug transporter by Hennessy, M., Spiers, J.P.

“…P-glycoprotein (P-gp) the multidrug transporter is a well-characterised member of the super-family of ATP-binding cassette (ABC) transporters, and mediates the…”
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Evaluation of the role of a specialist tracheostomy service. From critical care to outreach and beyond by Norwood, M G A, Spiers, P, Bailiss, J, Sayers, R D

“…The impact that a new specialist tracheostomy service, designed specifically for the care of patients with tracheostomies, was assessed in terms of type of…”
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The Triple Risk Hypotheses in Sudden Infant Death Syndrome by Guntheroth, Warren G, Spiers, Philip S

“…Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for…”
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Extensive perinephric abscess complicated by herpes simplex virus 1 reactivation by Alleyne, S A, Bukhari, S S, Fraser, M, Spiers, P

“…A 43-year-old man, admitted with a swollen right thigh, was diagnosed with a deep vein thrombosis. On day 6 he became septic. A CT scan demonstrated a…”
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Bickerstaff’s brainstem encephalitis related to Campylobacter jejuni gastroenteritis by Hussain, A M, Flint, N J, Livsey, S A, Wong, R, Spiers, P, Bukhari, S S

“…The laboratory reported a high titre of C jejuni IgM on day 37. Because detection of the IgM antibody response to C jejuni could be unreliable, 5 we confirmed…”
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Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension : effects of endothelin receptor blockade by SPIERS, James P, KELSO, Elizabeth J, SIAH, Wei F, EDGE, Gillian, GUOJIE SONG, MCDERMOTT, Barbara J, HENNESSY, Martina

“…To determine the effects of age and dual endothelin (ET)A/ETB receptor antagonism (bosentan) on aortic matrix metalloproteinase (MMP) abundance and tissue…”
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The Effect of the Weekend on the Risk of Sudden Infant Death Syndrome by Spiers, P. S, Guntheroth, W. G

“…The risk of sudden infant death syndrome (SIDS) is associated strongly with socioeconomic status. However, many infants who live in one socioeconomic…”
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Accuracy of pulse oximetry in patients with low systemic vascular resistance by Secker, C., Spiers, P.

“…In order to assess the accuracy of pulse oximeters in patients with septic shock, we compared 80 paired readings of oxygen saturations taken from pulse…”
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Prolongation of the QT Interval and the Sudden Infant Death Syndrome by Guntheroth, Warren G, Spiers, Philip S

“…Guntheroth and Spiers discuss the recent discussions about the link between the QT interval and sudden infant death syndrome. They discount the hypothesis and…”
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The influence of race and gestational age on the age of maximum risk of SIDS in infancy by Spiers, P.S.

“…Risk of sudden infant death syndrome (SIDS) reaches a maximum in the third month. Thereafter, it decreases by half every 40 days or so. It is proposed that the…”
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