Search Results - "SPENDLOVE, Ian"

Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies by Dingjan, Tamir, Spendlove, Ian, Durrant, Lindy G., Scott, Andrew M., Yuriev, Elizabeth, Ramsland, Paul A.

“…•Dramatic glycosylation changes occur with carcinogenesis and cancer progression.•Tumor-associated carbohydrate antigens are candidates for targeting by…”
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Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided "immune-hot" colorectal cancers by Talhouni, Shahd, Fadhil, Wakkas, Mongan, Nigel P, Field, Lara, Hunter, Kelly, Makhsous, Sogand, Maciel-Guerra, Alexandre, Kaur, Nayandeep, Nestarenkaite, Ausrine, Laurinavicius, Arvydas, Willcox, Benjamin E, Dottorini, Tania, Spendlove, Ian, Jackson, Andrew M, Ilyas, Mohammad, Ramage, Judith M

“…Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells…”
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Vascular Endothelial Growth Factor Expression in Ovarian Cancer: A Model for Targeted Use of Novel Therapies? by Duncan, Timothy J, Al-Attar, Ahmad, Rolland, Phil, Scott, Ian V, Deen, Suha, Liu, David T Y, Spendlove, Ian, Durrant, Lindy G

“…Purpose: Angiogenesis has a vital role in tumor growth and metastasis, and vascular endothelial growth factor (VEGF) represents a potent cytokine in this…”
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Human Leukocyte Antigen Class I Antigen Expression Is an Independent Prognostic Factor in Ovarian Cancer by ROLLAND, Phil, DEEN, Suha, SCOTT, Ian, DURRANT, Lindy, SPENDLOVE, Ian

“…Purpose: Despite improvements in cancer treatment, the prognosis of ovarian cancer remains low and imperfectly predicted by traditional pathologic criteria…”
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Therapeutic targeting of Lewis(y) and Lewis(b) with a novel monoclonal antibody 692/29 by Noble, Philip, Spendlove, Ian, Harding, Stephen, Parsons, Tina, Durrant, Lindy G

“…Several monoclonal antibodies (mAbs) recognising Lewis(y), such as BR96, have reached the clinic but have failed to show good anti-tumour responses with an…”
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The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease by Rolland, Phil, Madjd, Zahra, Durrant, Lindy, Ellis, Ian O, Layfield, Rob, Spendlove, Ian

“…p62 is a multi-functional protein, which induces nuclear factor-κB (NFκB) activation through multiple upstream signalling pathways, including those triggered…”
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Total loss of MHC class I is an independent indicator of good prognosis in breast cancer by Madjd, Zahra, Spendlove, Ian, Pinder, Sarah E., Ellis, Ian O., Durrant, Lindy G.

“…Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast,…”
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A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia by Foxler, Daniel E, Bridge, Katherine S, Foster, John G, Grevitt, Paul, Curry, Sean, Shah, Kunal M, Davidson, Kathryn M, Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I, Kennedy, Paul T, Hermida, Miguel A, Chang, Ting‐Yu, Shaw, Peter E, Reynolds, Louise E, McKay, Tristan R, Wang, Hsei‐Wei, Ribeiro, Paulo S, Plevin, Michael J, Lagos, Dimitris, Lemoine, Nicholas R, Rajan, Prabhakar, Graham, Trevor A, Chelala, Claude, Hodivala‐Dilke, Kairbaan M, Spendlove, Ian, Sharp, Tyson V

“…The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors…”
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Expression of the stress‐related MHC class I chain‐related protein MICA is an indicator of good prognosis in colorectal cancer patients by Watson, Nicholas F.S., Spendlove, Ian, Madjd, Zahra, McGilvray, Roger, Green, Andrew R., Ellis, Ian O., Scholefield, John H., Durrant, Lindy G.

“…The realization of targeted cancer therapy has driven the need to improve selection of patients with colorectal cancer for adjuvant therapy, leading to a…”
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Increased IL-2 and Reduced TGF-β Upon T-Cell Stimulation are Associated with GM-CSF Upregulation in Multiple Immune Cell Types in Multiple Sclerosis by Aram, Jehan, Frakich, Nanci, Morandi, Elena, Alrouji, Mohammed, Samaraweera, Amal, Onion, David, Spendlove, Ian, Colombo, Sergio L., Tanasescu, Radu, Gran, Bruno, Constantinescu, Cris S.

“…Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays…”
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Structural and Functional Characterization of a Novel T Cell Receptor Co-regulatory Protein Complex, CD97-CD55 by Abbott, Rachel J.M., Spendlove, Ian, Roversi, Pietro, Fitzgibbon, Hannah, Knott, Vroni, Teriete, Peter, McDonnell, James M., Handford, Penny A., Lea, Susan M.

“…CD97, the archetypal member of the EGF-TM7 protein family, is constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells…”
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chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development by Sharp, Tyson V, Al-Attar, Ahmad, Foxler, Daniel E, Ding, Li, de A. Vallim, Thomas Q, Zhang, Yining, Nijmeh, Hala S, Webb, Thomas M, Nicholson, Andrew G, Zhang, Qunyuan, Kraja, Aldi, Spendlove, Ian, Osborne, John, Mardis, Elaine, Longmore, Gregory D

“…Loss of heterozygosity (LOH) and homozygous deletions at chromosome 3p21.3 are common in both small and nonsmall cell lung cancers, indicating the likely…”
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Loss of IFNγ Receptor Is an Independent Prognostic Factor in Ovarian Cancer by DUNCAN, Timothy J, ROLLAND, Phil, DEEN, Suha, SCOTT, Ian V, LIU, David T. Y, SPENDLOVE, Ian, DURRANT, Lindy G

“…Purpose: There is evidence that IFNγ plays an important role in ovarian cancer development. IFNγ produces numerous antitumor effects and it may be evasion of…”
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A Neoadjuvant/Adjuvant Randomized Trial of Colorectal Cancer Patients Vaccinated with an Anti-Idiotypic Antibody, 105AD7, Mimicking CD55 by Ullenhag, Gustav J, Spendlove, Ian, Watson, Nicholas F S, Indar, Adrian A, Dube, Mukul, Robins, Richard A, Maxwell-Armstrong, Charles, Scholefield, John H, Durrant, Lindy G

“…Purpose: To assess the tolerability and effectiveness of 105AD7 vaccination in colorectal cancer patients. 105AD7 is a human anti-idiotypic antibody mimicking…”
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Loss of CD55 Is Associated with Aggressive Breast Tumors by MADJD, Zahra, DURRANT, Lindy G, BRADLEY, Richard, SPENDLOVE, Ian, ELLIS, Ian O, PINDER, Sarah E

“…Purpose: CD55 is a complement regulatory protein expressed by cells to protect them from bystander attack by complement. CD55 is overexpressed on some tumor…”
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Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients by Watson, Nicholas F S, Madjd, Zahra, Scrimegour, Duncan, Spendlove, Ian, Ellis, Ian O, Scholefield, John H, Durrant, Lindy G

“…Advances in our understanding of the molecular biology of colorectal cancer have fuelled the search for novel molecular prognostic markers to complement…”
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Cytoplasmic expression of p27^kip1 is associated with a favourable prognosis in colorectal cancer patients by Watson, Nicholas FS

“…AIM： To evaluate the prognostic significance of p27^Kip1 in colorectal cancer patients. METHODS： Cytoplasmic and nuclear p27^Kip1 expression was evaluated in…”
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Cytoplasmic expression of p27kip1 is associated with a favourable prognosis in colorectal cancer patients by Watson, Nicholas FS, Durrant, Lindy G, Scholefield, John H, Madjd, Zahra, Scrimgeour, Duncan, Spendlove, Ian, Ellis, Ian O, Patel, Poulam M

“…R73; AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients.METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in…”
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δ 13C, δ18O, and 87Sr/86Sr Values Provide Insights Into the Behavioral Patterns of a Mammuthus jeffersonii During the Bølling-Allerød Interstadial Period by Spendlove, Ian Brent

“…Only two Jeffersonian mammoths (Mammuthus jeffersonii) have been proposed in the western United States. The Coplen Springs mammoth was proposed based on tooth…”
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Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis by Aithal, Guruprasad P, Thomas, James A, Kaye, Philip V, Lawson, Adam, Ryder, Stephen D, Spendlove, Ian, Austin, Andrew S, Freeman, Jan G, Morgan, Linda, Webber, Jonathan

“…Background & Aims: Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease for which there is limited therapy available. Insulin…”
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