Search Results - "SPENCER, Sade"

Repurposing anti-inflammatory medications for alcohol and substance use disorders by Ozburn, Angela R, Spencer, Sade M

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Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways) by Smith, Rachel J, Lobo, Mary Kay, Spencer, Sade, Kalivas, Peter W

“…Highlights ► Cocaine-induced adaptations in nucleus accumbens (NAc) contribute to relapse. ► Projection neurons in NAc are D1 or D2 dopamine…”
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Metformin Prevents Cocaine Sensitization: Involvement of Adenosine Monophosphate-Activated Protein Kinase Trafficking between Subcellular Compartments in the Corticostriatal Reward Circuit by Aruldas, Rachel, Orenstein, Laura Buczek, Spencer, Sade

“…Repeated cocaine exposure produces an enhanced locomotor response (sensitization) paralleled by biological adaptations in the brain. Previous studies…”
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Glutamate Transport: A New Bench to Bedside Mechanism for Treating Drug Abuse by Spencer, Sade, Kalivas, Peter W

“…Abstract Drug addiction has often been described as a “hijacking” of the brain circuits involved in learning and memory. Glutamate is the principal excitatory…”
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Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212–2 by Brewer, Abigail L., Felter, Claire E., Sternitzky, Anna R., Spencer, Sade M.

“…Synthetic cannabinoids are associated with higher risk of dependence and more intense withdrawal symptoms than plant-derived Δ9-tetrahydrocannabinol (THC)…”
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Systematic review of sex differences in the relationship between hormones and depression in HIV by Turk, Morgan C., Bakker, Caitlin J., Spencer, Sade M., Lofgren, Sarah M.

“…Major depressive disorder is the most common neuropsychiatric comorbidity of human immunodeficiency virus (HIV), and women are more frequently affected in the…”
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Direct Regulation of Diurnal Drd3 Expression and Cocaine Reward by NPAS2 by Ozburn, Angela R, Falcon, Edgardo, Twaddle, Alan, Nugent, Alexandria L, Gillman, Andrea G, Spencer, Sade M, Arey, Rachel N, Mukherjee, Shibani, Lyons-Weiler, James, Self, David W, McClung, Colleen A

“…Abstract Background Circadian gene disruptions are associated with the development of psychiatric disorders, including addiction. However, the mechanisms by…”
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Metformin in nucleus accumbens core reduces cue‐induced cocaine seeking in male and female rats by Chan, Amy, Willard, Alexis, Mulloy, Sarah, Ibrahim, Noor, Sciaccotta, Allegra, Schonfeld, Mark, Spencer, Sade M.

“…This study investigated the potential therapeutic effects of the FDA‐approved drug metformin on cue‐induced reinstatement of cocaine seeking. Metformin…”
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The loss of NMDAR‐dependent LTD following cannabinoid self‐administration is restored by positive allosteric modulation of CB1 receptors by Neuhofer, Daniela, Spencer, Sade M., Chioma, Vivian C., Beloate, Lauren N., Schwartz, Danielle, Kalivas, Peter W.

“…Glutamatergic plasticity in the nucleus accumbens core (NAcore) is a key neuronal process in appetitive learning and contributes to pathologies such as drug…”
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Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior by Spencer, Sade, Falcon, Edgardo, Kumar, Jaswinder, Krishnan, Vaishnav, Mukherjee, Shibani, Birnbaum, Shari G., McClung, Colleen A.

“…It has been suggested for some time that circadian rhythm abnormalities underlie the development of multiple psychiatric disorders. However, it is unclear how…”
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Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine‐seeking behavior by Namba, Mark D., Kupchik, Yonatan M., Spencer, Sade M., Garcia‐Keller, Constanza, Goenaga, Julianna G., Powell, Gregory L., Vicino, Ian A., Hogue, Ian B., Gipson, Cassandra D.

“…Nicotine self‐administration is associated with decreased expression of the glial glutamate transporter (GLT‐1) and the cystine‐glutamate exchange protein xCT…”
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The Role of Clock in Ethanol-Related Behaviors by OZBURN, Angela Renee, FALCON, Edgardo, MUKHERJEE, Shibani, GILLMAN, Andrea, AREY, Rachel, SPENCER, Sade, MCCLUNG, Colleen A

“…Mice with a mutation in the Clock gene (ClockΔ19) exhibit increased preference for stimulant rewards and sucrose. They also have an increase in dopaminergic…”
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A mutation in CLOCK leads to altered dopamine receptor function by Spencer, Sade, Torres-Altoro, Melissa I., Falcon, Edgardo, Arey, Rachel, Marvin, Marian, Goldberg, Matthew, Bibb, James A., McClung, Colleen A.

“…Mice with a mutation in the Clock gene (ClockΔ19) have a number of behavioral phenotypes that suggest alterations in dopaminergic transmission. These include…”
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Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking by Roberts‐Wolfe, Douglas J., Heinsbroek, Jasper A., Spencer, Sade M., Bobadilla, Ana Clara, Smith, Alexander C.W., Gipson, Cassandra D., Kalivas, Peter W.

“…Repeated exposure to drug‐associated cues without reward (extinction) leads to refraining from drug seeking in rodents. We determined if refraining is…”
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Framework for advancing equity in academic medicine and science: Perspectives from early career female faculty during the COVID-19 pandemic by Spencer, Sade, Burrows, Catherine, Lacher, Sarah E., Macheledt, Kait C., Berge, Jerica M., Ghebre, Rahel G.

“…Early-career female faculty, both physician scientists and basic researchers, have disproportionately experienced negative professional, financial, and…”
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ACNP 61st Annual Meeting: Panels, Mini-Panels and Study Groups

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Chronic treatment with N‐acetylcysteine decreases extinction responding and reduces cue‐induced nicotine‐seeking by Powell, Gregory L., Leyrer‐Jackson, Jonna M., Goenaga, Julianna, Namba, Mark D., Piña, Jose, Spencer, Sade, Stankeviciute, Neringa, Schwartz, Danielle, Allen, Nicholas P., Del Franco, Armani P., McClure, Erin A., Olive, Michael Foster, Gipson, Cassandra D.

“…N‐acetylcysteine (NAC), a promising glutamatergic therapeutic agent, has shown some clinical efficacy in reducing nicotine use in humans and has been shown to…”
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Which came first: Cannabis use or deficits in impulse control? by Rinehart, Linda, Spencer, Sade

“…Impulse control deficits are often found to co-occur with substance use disorders (SUDs). On the one hand, it is well known that chronic intake of drugs of…”
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0970 The impact of the COVID-19 pandemic on healthcare academicians’ sleep quantity and quality by Macheledt, Kait, Berge, Jerica, Spencer, Sade, Pusalavidyasagar, Snigdhasmrithi

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The good and bad news about glutamate in drug addiction by Spencer, Sade, Scofield, Michael, Kalivas, Peter W

“…In 1998 we published a perspective review describing how drug-induced neuroadaptations might serve towards understanding drug craving. We proposed experimental…”
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