Search Results - "SPENCER, Dennis D"

The roles of surgery and technology in understanding focal epilepsy and its comorbidities by Spencer, Dennis D, Gerrard, Jason L, Zaveri, Hitten P

“…Intracranial electrophysiological recording in patients with refractory focal epilepsy is the gold standard for defining epileptogenic tissue. Although the…”
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Imaging synaptic density in the living human brain by Finnema, Sjoerd J, Nabulsi, Nabeel B, Eid, Tore, Detyniecki, Kamil, Lin, Shu-Fei, Chen, Ming-Kai, Dhaher, Roni, Matuskey, David, Baum, Evan, Holden, Daniel, Spencer, Dennis D, Mercier, Joël, Hannestad, Jonas, Huang, Yiyun, Carson, Richard E

“…Chemical synapses are the predominant neuron-to-neuron contact in the central nervous system. Presynaptic boutons of neurons contain hundreds of vesicles…”
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Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program by Çavuş, Idil, Romanyshyn, Jonathan C., Kennard, Jeremy T., Farooque, Pue, Williamson, Anne, Eid, Tore, Spencer, Susan S., Duckrow, Robert, Dziura, James, Spencer, Dennis D.

“…Objective Aberrant glutamate and γ‐aminobutyric acid (GABA) neurotransmission contribute to seizure generation and the epileptic state. However, whether levels…”
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The spatial and signal characteristics of physiologic high frequency oscillations by Alkawadri, Rafeed, Gaspard, Nicolas, Goncharova, Irina I., Spencer, Dennis D., Gerrard, Jason L., Zaveri, Hitten, Duckrow, Robert B., Blumenfeld, Hal, Hirsch, Lawrence J.

“…Summary Objectives To study the incidence, spatial distribution, and signal characteristics of high frequency oscillations (HFOs) outside the epileptic…”
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Mapping the structure-function relationship along macroscale gradients in the human brain by Collins, Evan, Chishti, Omar, Obaid, Sami, McGrath, Hari, King, Alex, Shen, Xilin, Arora, Jagriti, Papademetris, Xenophon, Constable, R. Todd, Spencer, Dennis D., Zaveri, Hitten P.

“…Functional coactivation between human brain regions is partly explained by white matter connections; however, how the structure-function relationship varies by…”
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High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter by McGrath, Hari, Zaveri, Hitten P., Collins, Evan, Jafar, Tamara, Chishti, Omar, Obaid, Sami, Ksendzovsky, Alexander, Wu, Kun, Papademetris, Xenophon, Spencer, Dennis D.

“…Precise cortical brain localization presents an important challenge in the literature. Brain atlases provide data-guided parcellation based on functional and…”
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A comparison of the power spectral density of scalp EEG and subjacent electrocorticograms by Petroff, Ognen A, Spencer, Dennis D, Goncharova, Irina I, Zaveri, Hitten P

“…Highlights • The power of the scalp EEG, in the canonical frequency bands, was between 6% and 15% of the power recorded by the subjacent ECoG. • A greater…”
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Functional MRI connectivity as a predictor of the surgical outcome of epilepsy by Negishi, Michiro, Martuzzi, Roberto, Novotny, Edward J., Spencer, Dennis D., Constable, R. Todd

“…Summary Purpose:  In planning epilepsy surgery, it is important to be able to assess the likelihood of success of surgery for each patient so that the possible…”
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Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom by Sivaraju, Adithya, Quraishi, Imran, Collins, Evan, McGrath, Hari, Ramos, Alexander, Turk-Browne, Nicholas B., Zaveri, Hitten, Damisah, Eyiyemisi, Spencer, Dennis D., Hirsch, Lawrence J.

“…To prospectively investigate the utility of seizure induction using systematic 1 Hz stimulation by exploring its concordance with the spontaneous seizure onset…”
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Expanding Brain-Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy by Gummadavelli, Abhijeet, Zaveri, Hitten P, Spencer, Dennis D, Gerrard, Jason L

“…Seizures have traditionally been considered hypersynchronous excitatory events and epilepsy has been separated into focal and generalized epilepsy based…”
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The relationship between seizures, interictal spikes and antiepileptic drugs by Goncharova, Irina I, Alkawadri, Rafeed, Gaspard, Nicolas, Duckrow, Robert B, Spencer, Dennis D, Hirsch, Lawrence J, Spencer, Susan S, Zaveri, Hitten P

“…Highlights • Interictal EEG spikes demonstrate a considerable diurnal variation with a night-time peak and day-time trough. • Spike rate decreases with AED…”
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Impaired consciousness in temporal lobe seizures: role of cortical slow activity by Englot, Dario J., Yang, Li, Hamid, Hamada, Danielson, Nathan, Bai, Xiaoxiao, Marfeo, Anthony, Yu, Lissa, Gordon, Aliza, Purcaro, Michael J., Motelow, Joshua E., Agarwal, Ravi, Ellens, Damien J., Golomb, Julie D., Shamy, Michel C. F., Zhang, Heping, Carlson, Chad, Doyle, Werner, Devinsky, Orrin, Vives, Kenneth, Spencer, Dennis D., Spencer, Susan S., Schevon, Catherine, Zaveri, Hitten P., Blumenfeld, Hal

“…Impaired consciousness requires altered cortical function. This can occur either directly from disorders that impair widespread bilateral regions of the cortex…”
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Intrastimulation discharges during electrical stimulation mapping May help identify seizure onset network by Sivaraju, Adithya, Spencer, Dennis D., Hirsch, Lawrence J.

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Age-dependent vestibular cingulate–cerebral network underlying gravitational perception: a cross-sectional multimodal study by Plute, Tritan J., Spencer, Dennis D., Alkawadri, Rafeed

“…Background and objectives The cingulate gyrus (CG) is a frequently studied yet not wholly understood area of the human cerebrum. Previous studies have…”
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7T MR spectroscopic imaging in the localization of surgical epilepsy by Pan, Jullie W., Duckrow, Robert B., Gerrard, Jason, Ong, Caroline, Hirsch, Lawrence J., Resor, Stanley R., Zhang, Yan, Petroff, Ognen, Spencer, Susan, Hetherington, Hoby P., Spencer, Dennis D.

“…Summary Purpose With the success that surgical approaches can provide for localization‐related epilepsy, accurate seizure localization remains important…”
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The changing landscape in epilepsy imaging: Unmasking subtle and unique entities by Adin, Mehmet E, Durand, David, Zucconi, William B, Huttner, Anita J, Spencer, Dennis D, Bronen, Richard A

“…Dramatic changes have occurred recently in the field of epilepsy, including a fundamental shift in the etiology of epileptogenic substrates found at surgery…”
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A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories by De Lanerolle, Nihal C., Kim, Jung H., Williamson, Anne, Spencer, Susan S., Zaveri, Hitten P., Eid, Toye, Spencer, Dennis D.

“…Purpose: This study is a retrospective analysis of the pathology of the hippocampus from patients with medically intractable temporal lobe epilepsy. We…”
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Stability of infraslow correlation structure in time-shifted intracranial EEG signals by Joshi, Rasesh B, Duckrow, Robert B, Goncharova, Irina I, Hirsch, Lawrence J, Spencer, Dennis D, Godwin, Dwayne W, Zaveri, Hitten P

“…It is increasingly understood that the epilepsies are characterized by network pathology that can span multiple spatial and temporal scales. Recent work…”
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Extracellular metabolites in the cortex and hippocampus of epileptic patients by Cavus, Idil, Kasoff, Willard S., Cassaday, Michael P., Jacob, Ralph, Gueorguieva, Ralitza, Sherwin, Robert S., Krystal, John H., Spencer, Dennis D., Abi-Saab, Walid M.

“…Interictal brain energy metabolism and glutamate–glutamine cycling are impaired in epilepsy and may contribute to seizure generation. We used the zero‐flow…”
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Loss of Perivascular Aquaporin 4 May Underlie Deficient Water and K+Homeostasis in the Human Epileptogenic Hippocampus by Eid, Tore, Lee, Tih-Shih W., Thomas, Marion J., Amiry-Moghaddam, Mahmood, Bjørnsen, Lars P., Spencer, Dennis D., Agre, Peter, Ottersen, Ole P., de Lanerolle, Nihal C.

“…An abnormal accumulation of extracellular K+in the brain has been implicated in the generation of seizures in patients with mesial temporal lobe epilepsy…”
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