Search Results - "SPELEMAN, F"

Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project by Schleiermacher, G, Mosseri, V, London, W B, Maris, J M, Brodeur, G M, Attiyeh, E, Haber, M, Khan, J, Nakagawara, A, Speleman, F, Noguera, R, Tonini, G P, Fischer, M, Ambros, I, Monclair, T, Matthay, K K, Ambros, P, Cohn, S L, Pearson, A D J

“…Background: In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN…”
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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation by Sprüssel, A, Schulte, J H, Weber, S, Necke, M, Händschke, K, Thor, T, Pajtler, K W, Schramm, A, König, K, Diehl, L, Mestdagh, P, Vandesompele, J, Speleman, F, Jastrow, H, Heukamp, L C, Schüle, R, Dührsen, U, Buettner, R, Eggert, A, Göthert, J R

“…Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a potential therapeutic target in solid cancers and more recently in acute myeloid…”
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MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival by Afanasyeva, E A, Mestdagh, P, Kumps, C, Vandesompele, J, Ehemann, V, Theissen, J, Fischer, M, Zapatka, M, Brors, B, Savelyeva, L, Sagulenko, V, Speleman, F, Schwab, M, Westermann, F

“…Several microRNA (miRNA) loci are found within genomic regions frequently deleted in primary neuroblastoma, including miR-885-5p at 3p25.3. In this study, we…”
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Emergence of new ALK mutations at relapse of neuroblastoma by Schleiermacher, Gudrun, Javanmardi, Niloufar, Bernard, Virginie, Leroy, Quentin, Cappo, Julie, Rio Frio, Thomas, Pierron, Gaelle, Lapouble, Eve, Combaret, Valérie, Speleman, Frank, de Wilde, Bram, Djos, Anna, Ora, Ingrid, Hedborg, Fredrik, Träger, Catarina, Holmqvist, Britt-Marie, Abrahamsson, Jonas, Peuchmaur, Michel, Michon, Jean, Janoueix-Lerosey, Isabelle, Kogner, Per, Delattre, Olivier, Martinsson, Tommy

“…In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal…”
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MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells by Schulte, J H, Lindner, S, Bohrer, A, Maurer, J, De Preter, K, Lefever, S, Heukamp, L, Schulte, S, Molenaar, J, Versteeg, R, Thor, T, Künkele, A, Vandesompele, J, Speleman, F, Schorle, H, Eggert, A, Schramm, A

“…Neuroblastoma is an embryonal tumor with a heterogeneous clinical course. The tumor is presumed to be derived from the neural crest, but the cells of origin…”
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A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies by Althoff, K, Beckers, A, Bell, E, Nortmeyer, M, Thor, T, Sprüssel, A, Lindner, S, De Preter, K, Florin, A, Heukamp, L C, Klein-Hitpass, L, Astrahantseff, K, Kumps, C, Speleman, F, Eggert, A, Westermann, F, Schramm, A, Schulte, J H

“…Neuroblastoma, a childhood cancer that originates from neural crest-derived cells, is the most common deadly solid tumor of infancy. Amplification of the MYCN…”
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RTPrimerDB: the portal for real-time PCR primers and probes by Lefever, Steve, Vandesompele, Jo, Speleman, Frank, Pattyn, Filip

“…RTPrimerDB (http://www.rtprimerdb.org) is a freely accessible database and analysis tool for real-time quantitative PCR assays. RTPrimerDB includes records…”
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International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee by Ambros, P F, Ambros, I M, Brodeur, G M, Haber, M, Khan, J, Nakagawara, A, Schleiermacher, G, Speleman, F, Spitz, R, London, W B, Cohn, S L, Pearson, A D J, Maris, J M

“…Neuroblastoma serves as a paradigm for utilising tumour genomic data for determining patient prognosis and treatment allocation. However, before the…”
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Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs by Das, S, Bryan, K, Buckley, P G, Piskareva, O, Bray, I M, Foley, N, Ryan, J, Lynch, J, Creevey, L, Fay, J, Prenter, S, Koster, J, van Sluis, P, Versteeg, R, Eggert, A, Schulte, J H, Schramm, A, Mestdagh, P, Vandesompele, J, Speleman, F, Stallings, R L

“…MicroRNAs (miRNAs) contribute to the pathogenesis of many forms of cancer, including the pediatric cancer neuroblastoma, but the underlying mechanisms leading…”
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MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia by Mets, E, Van der Meulen, J, Van Peer, G, Boice, M, Mestdagh, P, Van de Walle, I, Lammens, T, Goossens, S, De Moerloose, B, Benoit, Y, Van Roy, N, Clappier, E, Poppe, B, Vandesompele, J, Wendel, H-G, Taghon, T, Rondou, P, Soulier, J, Van Vlierberghe, P, Speleman, F

“…The MYB oncogene is a leucine zipper transcription factor essential for normal and malignant hematopoiesis. In T-cell acute lymphoblastic leukemia (T-ALL),…”
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PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis by Garcia, E. G., Veloso, A., Oliveira, M. L., Allen, J. R., Loontiens, S., Brunson, D., Do, D., Yan, C., Morris, R., Iyer, S., Garcia, S. P., Iftimia, N., Van Loocke, W., Matthijssens, F., McCarthy, K., Barata, J. T., Speleman, F., Taghon, T., Gutierrez, A., Van Vlierberghe, P., Haas, W., Blackburn, J. S., Langenau, D. M.

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes and is largely driven by the NOTCH/MYC pathway. Yet, additional oncogenic…”
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Emerging patterns of cryptic chromosomal imbalance in patients with idiopathic mental retardation and multiple congenital anomalies: a new series of 140 patients and review of published reports by Menten, B, Maas, N, Thienpont, B, Buysse, K, Vandesompele, J, Melotte, C, de Ravel, T, Van Vooren, S, Balikova, I, Backx, L, Janssens, S, De Paepe, A, De Moor, B, Moreau, Y, Marynen, P, Fryns, J-P, Mortier, G, Devriendt, K, Speleman, F, Vermeesch, J R

“…Background: Chromosomal abnormalities are a major cause of mental retardation and multiple congenital anomalies (MCA/MR). Screening for these chromosomal…”
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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours by Mestdagh, P, Fredlund, E, Pattyn, F, Rihani, A, Van Maerken, T, Vermeulen, J, Kumps, C, Menten, B, De Preter, K, Schramm, A, Schulte, J, Noguera, R, Schleiermacher, G, Janoueix-Lerosey, I, Laureys, G, Powel, R, Nittner, D, Marine, J-C, Ringnér, M, Speleman, F, Vandesompele, J

“…Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the…”
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PHF6 mutations in adult acute myeloid leukemia by Van Vlierberghe, P, Patel, J, Abdel-Wahab, O, Lobry, C, Hedvat, C V, Balbin, M, Nicolas, C, Payer, A R, Fernandez, H F, Tallman, M S, Paietta, E, Melnick, A, Vandenberghe, P, Speleman, F, Aifantis, I, Cools, J, Levine, R, Ferrando, A

“…Loss of function mutations and deletions encompassing the plant homeodomain finger 6 ( PHF6 ) gene are present in about 20% of T-cell acute lymphoblastic…”
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NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951 by Clappier, E, Collette, S, Grardel, N, Girard, S, Suarez, L, Brunie, G, Kaltenbach, S, Yakouben, K, Mazingue, F, Robert, A, Boutard, P, Plantaz, D, Rohrlich, P, van Vlierberghe, P, Preudhomme, C, Otten, J, Speleman, F, Dastugue, N, Suciu, S, Benoit, Y, Bertrand, Y, Cavé, H

“…Risk-adjusted treatment stratification in T-cell acute lymphoblastic leukemias (T-ALLs) is currently based only on early response to chemotherapy. We…”
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Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia by Wallaert, A, Durinck, K, Van Loocke, W, Van de Walle, I, Matthijssens, F, Volders, P J, Avila Cobos, F, Rombaut, D, Rondou, P, Mestdagh, P, Vandesompele, J, Poppe, B, Taghon, T, Soulier, J, Van Vlierberghe, P, Speleman, F

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Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma by Ban, J, Jug, G, Mestdagh, P, Schwentner, R, Kauer, M, Aryee, D N T, Schaefer, K-L, Nakatani, F, Scotlandi, K, Reiter, M, Strunk, D, Speleman, F, Vandesompele, J, Kovar, H

“…EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that has a central and rate-limiting role in the pathogenesis of Ewing's sarcoma…”
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Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14 -MDM2-p53 axis by Van Maerken, T, Vandesompele, J, Rihani, A, De Paepe, A, Speleman, F

“…A primary failsafe program against unrestrained proliferation and oncogenesis is provided by the p53 tumor suppressor protein, inactivation of which is…”
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MYCN c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN c-MYC-activated tumors by Mestdagh, P, Fredlund, E, Pattyn, F, Schulte, J H, Muth, D, Vermeulen, J, Kumps, C, Schlierf, S, De Preter, K, Van Roy, N, Noguera, R, Laureys, G, Schramm, A, Eggert, A, Westermann, F, Speleman, F, Vandesompele, J

“…Increased activity of MYC protein-family members is a common feature in many cancers. Using neuroblastoma as a tumor model, we established a microRNA (miRNA)…”
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International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee by AMBROS, P. F, AMBROS, M, COHN, S. L, PEARSON, Adj, MARIS, J. M, BRODEUR, G. M, HABER, M, KHAN, J, NAKAGAWARA, A, SCHLEIERMACHER, G, SPELEMAN, F, SPITZ, R, LONDON, W. B

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