Search Results - "SPECTOR, Stephen A"

Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy by Campbell, Grant R, Spector, Stephen A

“…Low vitamin D levels in human immunodeficiency virus type-1 (HIV) infected persons are associated with more rapid disease progression and increased risk for…”
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Human Immunodeficiency Virus Type 1 and Methamphetamine-Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons by Teodorof-Diedrich, Carmen, Spector, Stephen A

“…Methamphetamine, a potent psychostimulant, is a highly addictive drug commonly used by persons living with HIV (PLWH), and its use can result in cognitive…”
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HIV Type 1 gp120-Induced Expansion of Myeloid Derived Suppressor Cells Is Dependent on Interleukin 6 and Suppresses Immunity by Garg, Ankita, Spector, Stephen A.

“…Background, Factors responsible for myeloid-derived suppressor cell (MDSC) expansion and T-cell dysfunction during human immunodeficiency virus type 1 (HIV)…”
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Current strategies to induce selective killing of HIV‐1‐infected cells by Campbell, Grant R., Spector, Stephen A.

“…Although combination antiretroviral therapy (ART) has led to significant HIV‐1 suppression and improvement in immune function, persistent viral reservoirs…”
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Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration by Campbell, Grant R, Rawat, Pratima, Bruckman, Rachel S, Spector, Stephen A

“…HIV Nef acts as an anti-autophagic maturation factor through interaction with beclin-1 (BECN1). We report that exposure of macrophages to infectious or…”
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TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function by Campbell, Grant R, To, Rachel K, Spector, Stephen A

“…Macrophages are a reservoir for latent human immunodeficiency type 1 (HIV) infection and a barrier to HIV eradication. In contrast to CD4 T cells, macrophages…”
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Identification of a candidate therapeutic autophagy-inducing peptide by Shoji-Kawata, Sanae, Sumpter, Rhea, Leveno, Matthew, Campbell, Grant R., Zou, Zhongju, Kinch, Lisa, Wilkins, Angela D., Sun, Qihua, Pallauf, Kathrin, MacDuff, Donna, Huerta, Carlos, Virgin, Herbert W., Helms, J. Bernd, Eerland, Ruud, Tooze, Sharon A., Xavier, Ramnik, Lenschow, Deborah J., Yamamoto, Ai, King, David, Lichtarge, Olivier, Grishin, Nick V., Spector, Stephen A., Kaloyanova, Dora V., Levine, Beth

“…The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly,…”
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SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway by Campbell, Grant R., To, Rachel K., Hanna, Jonathan, Spector, Stephen A.

“…Macrophages promote an early host response to infection by releasing pro-inflammatory cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity…”
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Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1 by Campbell, Grant R, Spector, Stephen A

“…Toll-like receptors (TLR) are important in recognizing microbial pathogens and triggering host innate immune responses, including autophagy, and in the…”
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Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1 by Campbell, Grant R., Spector, Stephen A.

“…Low vitamin D levels in human immunodeficiency virus type-1 (HIV) infected persons are associated with more rapid disease progression and increased risk for…”
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Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication by Campbell, Grant R., Bruckman, Rachel S., Herns, Shayna D., Joshi, Shweta, Durden, Donald L., Spector, Stephen A.

“…In this study, we investigated the effects of the dual phosphatidylinositol 3-kinase/mechanistic target of rapamycin (PI3K/MTOR) inhibitor dactolisib…”
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Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA by Campbell, Grant R., Rawat, Pratima, Spector, Stephen A.

“…Abstract Macrophages promote an early host response to infection by releasing pro-inflammatory cytokines such as interleukin (IL) 1β (IL-1β), tumour necrosis…”
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Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1 by Campbell, Grant R., Bruckman, Rachel S., Chu, Yen-Lin, Spector, Stephen A.

“…Histone deacetylase inhibitors (HDACi) are being evaluated in a “shock-and-kill” therapeutic approach to reverse human immunodeficiency virus type-1 (HIV)…”
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CD4 + T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy by Zhang, Gang, Campbell, Grant R, Zhang, Qiangzhe, Maule, Erin, Hanna, Jonathan, Gao, Weiwei, Zhang, Liangfang, Spector, Stephen A

“…Therapeutic strategies that provide effective and broad-spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the…”
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Associations of Genetically Determined Continental Ancestry With CD4+ Count and Plasma HIV-1 RNA Beyond Self-Reported Race and Ethnicity by Brummel, Sean S, Singh, Kumud K, Maihofer, Adam X, Farhad, Mona, Qin, Min, Fenton, Terry, Nievergelt, Caroline M, Spector, Stephen A

“…BACKGROUND:Ancestry informative markers (AIMs) measure genetic admixtures within an individual beyond self-reported racial/ethnic (SRR) groups. Here, we used…”
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Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure by Campbell, Grant R., Spector, Stephen A.

“…Effective antiretroviral therapy has led to significant human immunodeficiency virus type 1 (HIV-1) suppression and improvement in immune function. However,…”
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Human Immunodeficiency Virus Type 1 gp120 and Tat Induce Mitochondrial Fragmentation and Incomplete Mitophagy in Human Neurons by Teodorof-Diedrich, Carmen, Spector, Stephen A

“…HIV enters the central nervous system (CNS) during the early stages of infection and can cause neurological dysfunction, including neurodegeneration and…”
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Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial by Baker, Jason V, Sharma, Shweta, Achhra, Amit C, Bernardino, Jose Ignacio, Bogner, Johannes R, Duprez, Daniel, Emery, Sean, Gazzard, Brian, Gordin, Jonathan, Grandits, Greg, Phillips, Andrew N, Schwarze, Siegfried, Soliman, Elsayed Z, Spector, Stephen A, Tambussi, Giuseppe, Lundgren, Jens

“…HIV infection and certain antiretroviral therapy (ART) medications increase atherosclerotic cardiovascular disease risk, mediated, in part, through traditional…”
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CCL2 Increases X4-tropic HIV-1 Entry into Resting CD4+ T Cells by Campbell, Grant R., Spector, Stephen A.

“…During human immunodeficiency virus type 1 (HIV-1) infection, there is a strong positive correlation between CCL2 levels and HIV viral load. To determine…”
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Raltegravir Pharmacokinetics in Neonates Following Maternal Dosing by Clarke, Diana F, Acosta, Edward P, Rizk, Matthew L, Bryson, Yvonne J, Spector, Stephen A, Mofenson, Lynne M, Handelsman, Edward, Teppler, Hedy, Welebob, Carolee, Persaud, Deborah, Cababasay, Mae P, Wang, JiaJia, Mirochnick, Mark

“…International Maternal Pediatric Adolescent AIDS Clinical Trials P1097 was a multicenter trial to determine washout pharmacokinetics and safety of in…”
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