Search Results - "SPECK, A"

Of lineage and legacy: the development of mammalian hematopoietic stem cells by Dzierzak, Elaine, Speck, Nancy A

“…The hematopoietic system is one of the first complex tissues to develop in the mammalian conceptus. Of particular interest in the field of developmental…”
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Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche by Tamplin, Owen J., Durand, Ellen M., Carr, Logan A., Childs, Sarah J., Hagedorn, Elliott J., Li, Pulin, Yzaguirre, Amanda D., Speck, Nancy A., Zon, Leonard I.

“…Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire blood system. We generated a highly specific transgenic reporter of…”
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Conversion of adult endothelium to immunocompetent haematopoietic stem cells by Lis, Raphael, Karrasch, Charles C., Poulos, Michael G., Kunar, Balvir, Redmond, David, Duran, Jose G. Barcia, Badwe, Chaitanya R., Schachterle, William, Ginsberg, Michael, Xiang, Jenny, Tabrizi, Arash Rafii, Shido, Koji, Rosenwaks, Zev, Elemento, Olivier, Speck, Nancy A., Butler, Jason M., Scandura, Joseph M., Rafii, Shahin

“…Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a…”
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Update on Aire and thymic negative selection by Passos, Geraldo A., Speck‐Hernandez, Cesar A., Assis, Amanda F., Mendes‐da‐Cruz, Daniella A.

“…Summary Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy, and was…”
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Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells by Chen, Michael J., Li, Yan, De Obaldia, Maria Elena, Yang, Qi, Yzaguirre, Amanda D., Yamada-Inagawa, Tomoko, Vink, Chris S., Bhandoola, Avinash, Dzierzak, Elaine, Speck, Nancy A.

“…Hematopoietic stem cells (HSCs) and an earlier wave of definitive erythroid/myeloid progenitors (EMPs) differentiate from hemogenic endothelial cells in the…”
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Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis by Barragán-Martínez, Carolina, Speck-Hernández, Cesar A, Montoya-Ortiz, Gladis, Mantilla, Rubén D, Anaya, Juan-Manuel, Rojas-Villarraga, Adriana

“…Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the…”
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Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner by Wanderley, Carlos W, Colón, David F, Luiz, João Paulo M, Oliveira, Francisco F, Viacava, Paula R, Leite, Caio A, Pereira, Janaina A, Silva, Camila M, Silva, Cassia R, Silva, Rangel L, Speck-Hernandez, Cesar A, Mota, José M, Alves-Filho, José C, Lima-Junior, Roberto C, Cunha, Thiago M, Cunha, Fernando Q

“…Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action of paclitaxel is based on microtubule…”
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Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells by Cai, Xiongwei, Gao, Long, Teng, Li, Ge, Jingping, Oo, Zaw Min, Kumar, Ashish R., Gilliland, D. Gary, Mason, Philip J., Tan, Kai, Speck, Nancy A.

“…The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating preleukemic stem…”
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Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production by Li, Yan, Esain, Virginie, Teng, Li, Xu, Jian, Kwan, Wanda, Frost, Isaura M, Yzaguirre, Amanda D, Cai, Xiongwei, Cortes, Mauricio, Maijenburg, Marijke W, Tober, Joanna, Dzierzak, Elaine, Orkin, Stuart H, Tan, Kai, North, Trista E, Speck, Nancy A

“…Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand…”
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Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells by Tober, Joanna, Yzaguirre, Amanda D, Piwarzyk, Eileen, Speck, Nancy A

“…The transcription factor Runx1 is essential for the formation of yolk sac-derived erythroid/myeloid progenitors (EMPs) and hematopoietic stem cells (HSCs) from…”
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The expression of Sox17 identifies and regulates haemogenic endothelium by Clarke, Raedun L., Yzaguirre, Amanda D., Yashiro-Ohtani, Yumi, Bondue, Antoine, Blanpain, Cedric, Pear, Warren S., Speck, Nancy A., Keller, Gordon

“…Haematopoietic stem cells (HSCs) emerge from a specialized population of endothelial cells, but the events that trigger the transition from endothelial to…”
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Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis by Guo, Hong, Ma, Ou, Speck, Nancy A., Friedman, Alan D.

“…Deletion of Runx1 in adult mice produces a myeloproliferative phenotype. We now find that Runx1 gene deletion increases marrow monocyte while reducing…”
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Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells by Chen, Changya, Yu, Wenbao, Tober, Joanna, Gao, Peng, He, Bing, Lee, Kiwon, Trieu, Tuan, Blobel, Gerd A., Speck, Nancy A., Tan, Kai

“…Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult HSCs with distinct functional properties. To better understand the…”
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Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis by Colón, David F, Wanderley, Carlos W, Franchin, Marcelo, Silva, Camila M, Hiroki, Carlos H, Castanheira, Fernanda V S, Donate, Paula B, Lopes, Alexandre H, Volpon, Leila C, Kavaguti, Silvia K, Borges, Vanessa F, Speck-Hernandez, Cesar A, Ramalho, Fernando, Carlotti, Ana P, Carmona, Fabio, Alves-Filho, Jose C, Liew, Foo Y, Cunha, Fernando Q

“…Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of…”
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RUNX1 Mutations in Inherited and Sporadic Leukemia by Bellissimo, Dana C, Speck, Nancy A

“…is a recurrently mutated gene in sporadic myelodysplastic syndrome and leukemia. Inherited mutations in cause familial platelet disorder with predisposition to…”
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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML by Riedel, Simone S., Lu, Congcong, Xie, Hongbo M., Nestler, Kevin, Vermunt, Marit W., Lenard, Alexandra, Bennett, Laura, Speck, Nancy A., Hanamura, Ichiro, Lessard, Julie A., Blobel, Gerd A., Garcia, Benjamin A., Bernt, Kathrin M.

“…Meningioma-1 (MN1) overexpression in AML is associated with poor prognosis, and forced expression of MN1 induces leukemia in mice. We sought to determine how…”
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CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells by Li, Yan, Gao, Long, Hadland, Brandon, Tan, Kai, Speck, Nancy A.

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Endothelio-Mesenchymal Interaction Controls runx1 Expression and Modulates the notch Pathway to Initiate Aortic Hematopoiesis by Richard, Charlotte, Drevon, Cécile, Canto, Pierre-Yves, Villain, Gaelle, Bollérot, Karine, Lempereur, Aveline, Teillet, Marie-Aimée, Vincent, Christine, Rosselló Castillo, Catalina, Torres, Miguel, Piwarzyk, Eileen, Speck, Nancy A., Souyri, Michèle, Jaffredo, Thierry

“…Hematopoietic stem cells (HSCs) are produced by a small cohort of hemogenic endothelial cells (ECs) during development through the formation of intra-aortic…”
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Stress Can Be a Good Thing for Blood Formation by Speck, Nancy A.

“…Like politics, most developmental signals are local. However, in this issue of Cell Stem Cell, Kwan et al. (2016) and colleagues describe how a stress-induced…”
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Runx1 loss minimally impacts long-term hematopoietic stem cells by Cai, Xiongwei, Gaudet, Justin J, Mangan, James K, Chen, Michael J, De Obaldia, Maria Elena, Oo, Zaw, Ernst, Patricia, Speck, Nancy A

“…RUNX1 encodes a DNA binding subunit of the core-binding transcription factors and is frequently mutated in acute leukemia, therapy-related leukemia,…”
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