Search Results - "SPEAR, B. B"

Clinical application of pharmacogenetics by Spear, Brian B, Heath-Chiozzi, Margo, Huff, Jeffrey

“…Pharmacogenetics encompasses the involvement of genes in an individual's response to drugs. As such, the field covers a vast area including basic drug…”
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Selective electron beam sensing through coherent Cherenkov diffraction radiation by Senes, E., Krupa, M., Mazzoni, S., Lasocha, K., Lefevre, T., Schloegelhofer, A., Wendt, M., Davut, C., Karataev, P., Pakuza, C., Spear, B.

“…We exploit the coherent emission of Cherenkov diffraction radiation (ChDR) by a relativistic electron beam to sense its position even in the presence of other…”
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Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation by Spear, B. T, Jin, L, Ramasamy, S, Dobierzewska, A

“…Liver function is crucial for maintaining metabolic homeostasis in mammals. Numerous genes must be properly regulated for the liver to develop and perform a…”
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Pharmacogenetics: improving drug and dose selection by Bhathena, Anahita, Spear, Brian B

“…Considerable interindividual variability exists in patient responses to drug therapy. Differences in DNA sequence can affect the disposition, efficacy, and…”
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Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin by LIGUORI, Michael J, ANDERSON, Mark G, BUKOFZER, Stanley, MCKIM, Jan Es, PREGENZER, Jeffrey F, RETIEF, Jacques, SPEAR, Brian B, WARING, Jeffrey F

“…Idiosyncratic drug toxicity, defined as toxicity that is dose independent, host dependent, and usually cannot be predicted during preclinical or early phases…”
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Response of seabirds to thermal boundaries in the tropical Pacific: the thermocline versus the Equatorial Front by Spear, Larry B., Ballance, Lisa T., Ainley, David G.

“…Our 10 yr study is the first to associate seabirds with oceanic boundaries, or fronts, in tropical oceans. It addresses the semi-permanent Equatorial Front,…”
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Cetacean distributions relative to ocean processes in the northern California Current System by Tynan, Cynthia T., Ainley, David G., Barth, John A., Cowles, Timothy J., Pierce, Stephen D., Spear, Larry B.

“…Associations between cetacean distributions, oceanographic features, and bioacoustic backscatter were examined during two process cruises in the northern…”
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Physical and biological variables affecting seabird distributions during the upwelling season of the northern California Current by Ainley, David G., Spear, Larry B., Tynan, Cynthia T., Barth, John A., Pierce, Stephen D., Glenn Ford, R., Cowles, Timothy J.

“…As a part of the GLOBEC-Northeast Pacific project, we investigated variation in the abundance of marine birds in the context of biological and physical habitat…”
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Pharmacogenetics and antiepileptic drugs by SPEAR, Brian B

“…Responses among patients to antiepileptic drugs (AEDs) may be highly variable, with respect to both drug efficacy and safety. Pharmacogenetics addresses the…”
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Variable responses of seabirds to change in marine climate: California Current, 1985–1994 by Oedekoven, Cornelia S., Ainley, David G., Spear, Larry B.

“…We conducted annual ship-board surveys to determine the density and distribution of seabirds off central California in relation to marine climate, from 1985 to…”
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Pharmacogenetics and Pharmacogenomics in Drug Development and Regulatory Decision Making: Report of the First FDA-PWG-PhRMA-DruSafe Workshop by Lesko, Lawrence J., Salerno, Ronald A., Spear, Brian B., Anderson, Donald C., Anderson, Timothy, Brazell, Celia, Collins, Jerry, Dorner, Andrew, Essayan, David, Gomez-Mancilla, Baltazar, Hackett, Joseph, Huang, Shiew-Mei, Ide, Susan, Killinger, Joanne, Leighton, John, Mansfield, Elizabeth, Meyer, Robert, Ryan, Stephen G., Schmith, Virginia, Shaw, Peter, Sistare, Frank, Watson, Mark, Worobec, Alexandra

“…The use of pharmacogenetics and pharmacogenomics in the drug development process, and in the assessment of such data submitted to regulatory agencies by…”
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Association of dopamine-related genetic loci to dopamine D3 receptor antagonist ABT-925 clinical response by Bhathena, A, Wang, Y, Kraft, J B, Idler, K B, Abel, S J, Holley-Shanks, R R, Robieson, W Z, Spear, B, Redden, L, Katz, D A

“…ABT-925, a selective dopamine D 3 receptor (DRD3) antagonist, was tested in schizophrenia. A DRD3 gene polymorphism results in an S9G amino-acid change that…”
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RETURNING GENETIC RESEARCH RESULTS TO INDIVIDUALS: POINTS-TO-CONSIDER by RENEGAR, GAILE, WEBSTER, CHRISTOPHER J., STUERZEBECHER, STEFFEN, HARTY, LEA, IDE, SUSAN E., BALKITE, BETH, ROGALSKI-SALTER, TARYN A., COHEN, NADINE, SPEAR, BRIAN B., BARNES, DIANE M., BRAZELL, CELIA

“…ABSTRACT This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic…”
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Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics by Katz, David A., Carr, Robert, Grimm, David R., Xiong, Hao, Holley‐Shanks, Rhonda, Mueller, Toby, Leake, Brenda, Wang, Qiang, Han, Lixin, Wang, Perry G., Edeki, Timi, Sahelijo, Leonardo, Doan, Thao, Allen, Andrew, Spear, Brian B., Kim, Richard B.

“…Objective Our objective was to learn whether genetic polymorphisms of metabolic enzymes or transport proteins provide a mechanistic understanding of the in…”
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Validating the Use of Generalized Additive Models and At-Sea Surveys to Estimate Size and Temporal Trends of Seabird Populations by Clarke, E. D., Spear, L. B., McCracken, M. L., Marques, F. F. C., Borchers, D. L., Buckland, S. T., Ainley, D. G.

“…1. The population size of seabirds is often difficult to estimate from surveys at breeding colonies because of factors such as burrow nesting and nocturnal…”
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Elements of informed consent for pharmacogenetic research; perspective of the pharmacogenetics working group by ANDERSON, D. C, GOMEZ-MANCILLA, B, MCHALE, D, HASHIMOTO, L, SANDBRINK, R, WATSON, M. L, SALERNO, R. A, COHEN, N, LISTER, C. E, SPEAR, B. B, BARNES, D. M, CHEESEMAN, K, SHAW, P. M, FRIEDMAN, J, MCCARTHY, A, BRAZELL, C, RAY, S. C

“…THE PHARMACOGENOMICS JOURNAL: (2002) 2, 284-292. doi:10.1038/sj.tpj.6500131…”
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Pharmacogenetics and Antiepileptic Drugs by Spear, Brian B.

“…Responses among patients to antiepileptic drugs (AEDs) may be highly variable, with respect to both drug efficacy and safety. Pharmacogenetics addresses the…”
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Flight speed of seabirds in relation to wind speed and direction by SPEAR, LARRY B., AINLEY, DAVID G.

“…We studied flight speed among all major seabird taxa. Our objectives were to provide further insight into dynamics of seabird flight and to develop allometric…”
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Variants in Apaf-1 segregating with major depression promote apoptosome function by Harlan, J, Chen, Y, Gubbins, E, Mueller, R, Roch, J-M, Walter, K, Lake, M, Olsen, T, Metzger, P, Dorwin, S, Ladror, U, Egan, D A, Severin, J, Johnson, R W, Holzman, T F, Voelp, K, Davenport, C, Beck, A, Potter, J, Gopalakrishnan, M, Hahn, A, Spear, B B, Halbert, D N, Sullivan, J P, Abkevich, V, Neff, C D, Skolnick, M H, Shattuck, D, Katz, D A

“…APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to…”
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The Importance of Long-term Acute Care Hospitals in the Regional Epidemiology of Klebsiella pneumoniae Carbapenemase–Producing Enterobacteriaceae by Lin, Michael Y., Lyles-Banks, Rosie D., Lolans, Karen, Hines, David W., Spear, Joel B., Petrak, Russell, Trick, William E., Weinstein, Robert A., Hayden, Mary K.

“…Background. In the United States, Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacteriaceae are increasingly detected in clinical infections;…”
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