Search Results - "SPAZZOLINI, Carla"

From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2 by Schwartz, Peter J, Gnecchi, Massimiliano, Dagradi, Federica, Castelletti, Silvia, Parati, Gianfranco, Spazzolini, Carla, Sala, Luca, Crotti, Lia

“…Abstract Aims Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two…”
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Exercise Training-Induced Repolarization Abnormalities Masquerading as Congenital Long QT Syndrome by Dagradi, Federica, Spazzolini, Carla, Castelletti, Silvia, Pedrazzini, Matteo, Kotta, Maria-Christina, Crotti, Lia, Schwartz, Peter J.

“…BACKGROUND:The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were…”
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Prevalence of the Congenital Long-QT Syndrome by SCHWARTZ, Peter J, STRAMBA-BADIALE, Marco, MOSCA, Fabio, NESPOLI, Luigi, RIMINI, Alessandro, ROSATI, Enrico, SALICE, Patrizia, SPAZZOLINI, Carla, CROTTI, Lia, PEDRAZZINI, Matteo, BESANA, Alessandra, BOSI, Giuliano, GABBARINI, Fulvio, GOULENE, Karine, INSOLIA, Roberto, MANNARINO, Savina

“…The prevalence of genetic arrhythmogenic diseases is unknown. For the long-QT syndrome (LQTS), figures ranging from 1:20 000 to 1:5000 were published, but none…”
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The genetics underlying acquired long QT syndrome: impact for genetic screening by Itoh, Hideki, Crotti, Lia, Aiba, Takeshi, Spazzolini, Carla, Denjoy, Isabelle, Fressart, Véronique, Hayashi, Kenshi, Nakajima, Tadashi, Ohno, Seiko, Makiyama, Takeru, Wu, Jie, Hasegawa, Kanae, Mastantuono, Elisa, Dagradi, Federica, Pedrazzini, Matteo, Yamagishi, Masakazu, Berthet, Myriam, Murakami, Yoshitaka, Shimizu, Wataru, Guicheney, Pascale, Schwartz, Peter J, Horie, Minoru

“…Acquired long QT syndrome (aLQTS) exhibits QT prolongation and Torsades de Pointes ventricular tachycardia triggered by drugs, hypokalaemia, or bradycardia…”
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Not All Beta-Blockers Are Equal in the Management of Long QT Syndrome Types 1 and 2 by Chockalingam, Priya, MBBS, PhD, Crotti, Lia, MD, PhD, Girardengo, Giulia, MD, Johnson, Jonathan N., MD, Harris, Katy M., MS, RN, van der Heijden, Jeroen F., MD, PhD, Hauer, Richard N.W., MD, PhD, Beckmann, Britt M., MD, Spazzolini, Carla, DVM, MS, Rordorf, Roberto, MD, Rydberg, Annika, MD, PhD, Clur, Sally-Ann B., MBBCh, MSc (Med), PhD, Fischer, Markus, MD, van den Heuvel, Freek, MD, PhD, Kääb, Stefan, MD, PhD, Blom, Nico A., MD, PhD, Ackerman, Michael J., MD, PhD, Schwartz, Peter J., MD, Wilde, Arthur A.M., MD, PhD

“…Objectives The purpose of this study was to compare the efficacy of beta-blockers in congenital long QT syndrome (LQTS). Background Beta-blockers are the…”
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The genetics underlying idiopathic ventricular fibrillation: A special role for catecholaminergic polymorphic ventricular tachycardia? by Leinonen, Jaakko T., Crotti, Lia, Djupsjöbacka, Aurora, Castelletti, Silvia, Junna, Nella, Ghidoni, Alice, Tuiskula, Annukka M., Spazzolini, Carla, Dagradi, Federica, Viitasalo, Matti, Kontula, Kimmo, Kotta, Maria-Christina, Widén, Elisabeth, Swan, Heikki, Schwartz, Peter J.

“…Ventricular fibrillation (VF) is a major cause of sudden cardiac death. In some cases clinical investigations fail to identify the underlying cause and the…”
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Risk Stratification in the Long-QT Syndrome by Priori, Silvia G, Schwartz, Peter J, Napolitano, Carlo, Bloise, Raffaella, Ronchetti, Elena, Grillo, Massimiliano, Vicentini, Alessandro, Spazzolini, Carla, Nastoli, Janni, Bottelli, Georgia, Folli, Roberta, Cappelletti, Donata

“…The most common causes of the inherited long-QT syndrome are mutations in either of two potassium-channel genes (at locus LQT1 or LQT2) or a sodium-channel…”
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Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: Implications for the clinical management of LQT3 patients by Calvillo, Laura, PhD, Spazzolini, Carla, DMV, MS, Vullo, Eleonora, MD, Insolia, Roberto, PhD, Crotti, Lia, MD, PhD, Schwartz, Peter J., MD, FHRS

“…Background The efficacy of beta-blockers for treatment of patients with long QT syndrome type 3 (LQT3) has been repeatedly questioned, and it has been…”
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Mutation location and I  Ks regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region by Schwartz, Peter J, Moreno, Cristina, Kotta, Maria-Christina, Pedrazzini, Matteo, Crotti, Lia, Dagradi, Federica, Castelletti, Silvia, Haugaa, Kristina H, Denjoy, Isabelle, Shkolnikova, Maria A, Brink, Paul A, Heradien, Marshall J, Seyen, Sandrine R M, Spätjens, Roel L H M G, Spazzolini, Carla, Volders, Paul G A

“…Abstract Aims Mutation type, location, dominant-negative I  Ks reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent I  Ks…”
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A comprehensive electrocardiographic, molecular, and echocardiographic study of Brugada syndrome: Validation of the 2013 diagnostic criteria by Savastano, Simone, MD, Rordorf, Roberto, MD, Vicentini, Alessandro, MD, Petracci, Barbara, MD, Taravelli, Erika, MD, Castelletti, Silvia, MD, D’Errico, Alessandra, MD, Torchio, Margherita, BS, Dossena, Cinzia, MD, Novara, Paola, MD, Dagradi, Federica, MD, Landolina, Maurizio, MD, Spazzolini, Carla, DVM, Crotti, Lia, MD, PhD, Schwartz, Peter J., MD, FHRS

“…Background The debate on the diagnostic value of high intercostal spaces (ICSs) and of the number of diagnostic leads in Brugada syndrome (BrS) has been…”
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Neural Control of Heart Rate Is an Arrhythmia Risk Modifier in Long QT Syndrome by Schwartz, Peter J., MD, FACC, Vanoli, Emilio, MD, Crotti, Lia, MD, PhD, Spazzolini, Carla, DVM, Ferrandi, Chiara, BSc, Goosen, Althea, BSc, Hedley, Paula, MSc, Heradien, Marshall, MD, Bacchini, Sara, MD, Turco, Annalisa, MD, La Rovere, Maria Teresa, MD, Bartoli, Antonella, PharmD, George, Alfred L., MD, Brink, Paul A., MD

“…Neural Control of Heart Rate Is an Arrhythmia Risk Modifier in Long QT Syndrome Peter J. Schwartz, Emilio Vanoli, Lia Crotti, Carla Spazzolini, Chiara…”
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Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome by SCHWARTZ, Peter J, PRIORI, Silvia G, ZAREBA, Wojciech, ROBINSON, Jennifer L, HALL, W. Jackson, BRINK, Paul A, TOIVONEN, Lauri, EPSTEIN, Andrew E, LI, Cuilan, HU, Dayi, CERRONE, Marina, SPAZZOLINI, Carla, ODERO, Attilio, NAPOLITANO, Carlo, BLOISE, Raffaella, DE FERRARI, Gaetano M, KLERSY, Catherine, MOSS, Arthur J

“…The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite beta-blockers is complex. We assessed the long-term…”
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All LQT3 patients need an ICD: True or false? by Schwartz, Peter J., MD, FHRS, Spazzolini, Carla, DVM, MS, Crotti, Lia, MD, PhD

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Tumor Necrosis Factor-α Predicts Response to Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure by Rordorf, Roberto, Savastano, Simone, Sanzo, Antonio, Spazzolini, Carla, Amici, Mara De, Camporotondo, Rita, Ghio, Stefano, Vicentini, Alessandro, Petracci, Barbara, Regibus, Valentina De, Taravelli, Erika, Landolina, Maurizio, Schwartz, Peter J.

“…Background:Pro-inflammatory cytokines contribute to the pathophysiology of heart failure (HF) and are up-regulated in affected patients. We investigated…”
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Rat experimental model of myocardial ischemia/reperfusion injury: an ethical approach to set up the analgesic management of acute post-surgical pain by Ciuffreda, Maria Chiara, Tolva, Valerio, Casana, Renato, Gnecchi, Massimiliano, Vanoli, Emilio, Spazzolini, Carla, Roughan, John, Calvillo, Laura

“…During the past 30 years, myocardial ischemia/reperfusion injury in rodents became one of the most commonly used model in cardiovascular research. Appropriate…”
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Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population by BRINK, Paul A, CROTTI, Lia, SPAZZOLINI, Carla, LUNDQUIST, Andrew L, RODEN, Dan M, GEORGE, Alfred L, SCHWARTZ, Peter J, CORFIELD, Valerie, GOOSEN, Althea, DURRHEIM, Glenda, HEDLEY, Paula, HERADIEN, Marshall, GELDENHUYS, Gerhard, VANOLI, Emilio, BACCHINI, Sara

“…In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation…”
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Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy by Spazzolini, Carla, DVM, Mullally, Jamie, BS, Moss, Arthur J., MD, Schwartz, Peter J., MD, McNitt, Scott, MS, Ouellet, Gregory, BS, Fugate, Thomas, BS, Goldenberg, Ilan, MD, Jons, Christian, MD, Zareba, Wojciech, MD, PhD, Robinson, Jennifer L., MS, Ackerman, Michael J., MD, PhD, Benhorin, Jesaia, MD, Crotti, Lia, MD, PhD, Kaufman, Elizabeth S., MD, Locati, Emanuela H., MD, PhD, Qi, Ming, PhD, Napolitano, Carlo, MD, Priori, Silvia G., MD, PhD, Towbin, Jeffrey A., MD, Vincent, G. Michael, MD

“…Objectives This study was designed to evaluate the clinical and prognostic aspects of long QT syndrome (LQTS)-related cardiac events that occur in the first…”
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Mutation-Specific Risk in Two Genetic Forms of Type 3 Long QT Syndrome by Liu, Judy F., BS, Moss, Arthur J., MD, Jons, Christian, MD, Benhorin, Jesaia, MD, Schwartz, Peter J., MD, Spazzolini, Carla, DVM, Crotti, Lia, MD, Ackerman, Michael J., MD, PhD, McNitt, Scott, MS, Robinson, Jennifer L., MS, Qi, Ming, PhD, Goldenberg, Ilan, MD, Zareba, Wojciech, MD, PhD

“…The clinical course of patients with 2 relatively common long QT syndrome type 3 mutations has not been well described. In the present study, we investigated…”
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Vagal Reflexes Following an Exercise Stress Test by Crotti, Lia, MD, PhD, Spazzolini, Carla, DVM, MS, Porretta, Alessandra P., MD, Dagradi, Federica, MD, Taravelli, Erika, MD, Petracci, Barbara, MD, Vicentini, Alessandro, MD, Pedrazzini, Matteo, PhD, La Rovere, Maria Teresa, MD, Vanoli, Emilio, MD, Goosen, Althea, RN, Heradien, Marshall, MD, George, Alfred L., MD, Brink, Paul A., MD, PhD, Schwartz, Peter J., MD

“…Objectives The study assessed whether heart rate (HR) reduction following an exercise stress test (ExStrT), an easily quantifiable marker of vagal reflexes,…”
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Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry by Crotti, Lia, Spazzolini, Carla, Tester, David J, Ghidoni, Alice, Baruteau, Alban-Elouen, Beckmann, Britt-Maria, Behr, Elijah R, Bennett, Jeffrey S, Bezzina, Connie R, Bhuiyan, Zahurul A, Celiker, Alpay, Cerrone, Marina, Dagradi, Federica, De Ferrari, Gaetano M, Etheridge, Susan P, Fatah, Meena, Garcia-Pavia, Pablo, Al-Ghamdi, Saleh, Hamilton, Robert M, Al-Hassnan, Zuhair N, Horie, Minoru, Jimenez-Jaimez, Juan, Kanter, Ronald J, Kaski, Juan P, Kotta, Maria-Christina, Lahrouchi, Najim, Makita, Naomasa, Norrish, Gabrielle, Odland, Hans H, Ohno, Seiko, Papagiannis, John, Parati, Gianfranco, Sekarski, Nicole, Tveten, Kristian, Vatta, Matteo, Webster, Gregory, Wilde, Arthur A M, Wojciak, Julianne, George, Alfred L, Ackerman, Michael J, Schwartz, Peter J

“…Abstract Aims Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of…”
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