Search Results - "SPASSOV, Danislav S"

Binding Affinity Determination in Drug Design: Insights from Lock and Key, Induced Fit, Conformational Selection, and Inhibitor Trapping Models by Spassov, Danislav S

“…Binding affinity is a fundamental parameter in drug design, describing the strength of the interaction between a molecule and its target protein. Accurately…”
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Inhibitor Trapping in Kinases by Spassov, Danislav S, Atanasova, Mariyana, Doytchinova, Irini

“…Recently, we identified a novel mechanism of enzyme inhibition in N-myristoyltransferases (NMTs), which we have named 'inhibitor trapping'. Inhibitor trapping…”
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Inhibitor Trapping in N-Myristoyltransferases as a Mechanism for Drug Potency by Spassov, Danislav S, Atanasova, Mariyana, Doytchinova, Irini

“…Predicting inhibitor potency is critical in drug design and development, yet it has remained one of computational biology's biggest unresolved challenges…”
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Novel Hits for N-Myristoyltransferase Inhibition Discovered by Docking-Based Screening by Spassov, Danislav S, Atanasova, Mariyana, Doytchinova, Irini

“…N-myristoyltransferase (NMT) inhibitors that were initially developed for treatment of parasitic protozoan infections, including sleeping sickness, malaria,…”
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A role of salt bridges in mediating drug potency: A lesson from the N-myristoyltransferase inhibitors by Spassov, Danislav S, Atanasova, Mariyana, Doytchinova, Irini

“…The salt bridge is the strongest non-covalent interaction in nature and is known to participate in protein folding, protein-protein interactions, and molecular…”
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A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src by Spassov, Danislav S., Ruiz-Saenz, Ana, Piple, Amit, Moasser, Mark M.

“…The mode of regulation of Src kinases has been elucidated by crystallographic studies identifying conserved structured protein modules involved in an orderly…”
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Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells by SPASSOV, Danislav S, WONG, Ching Hang, WONG, Sunny Y, REITER, Jeremy F, MOASSER, Mark M

“…The cell surface glycoprotein Trask/CDCP1 is phosphorylated during anchorage loss in epithelial cells in which it inhibits integrin clustering, outside-in…”
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Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling by Spassov, Danislav S., Wong, Ching Hang, Sergina, Natalia, Ahuja, Deepika, Fried, Michael, Sheppard, Dean, Moasser, Mark M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers by CHING HANG WONG, BAEHNER, Frederick L, SPASSOV, Danislav S, AHUJA, Deepika, DONGHUI WANG, HANN, Byron, BLAIR, Jimmy, SHOKAT, Kevan, WELM, Alana L, MOASSER, Mark M

“…Purpose: The frequently elevated activities of the c-src and c-yes products in human epithelial tumors suggest that these activated tyrosine kinases have…”
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The structural features of Trask that mediate its anti-adhesive functions by Spassov, Danislav S, Ahuja, Deepika, Wong, Ching Hang, Moasser, Mark M

“…Trask/CDCP1 is a transmembrane protein with a large extracellular and small intracellular domains. The intracellular domain (ICD) undergoes tyrosine…”
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Trask phosphorylation defines the reverse mode of a phosphotyrosine signaling switch that underlies cell anchorage state by Spassov, Danislav S, Wong, Ching H, Moasser, Mark M

“…Phosphotyrosine signaling in anchored epithelial cells constitutes a spacially ordained signaling program that largely functions to promote integrin-linked…”
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Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins by Spassov, Danislav S, Jurecic, Roland

“…Drosophila gene Pumilio (Pum) is a founder member of an evolutionarily conserved family of RNA-binding proteins that are present from yeast to mammals, and act…”
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CD318 is a ligand for CD6 by Enyindah-Asonye, Gospel, Li, Yan, Ruth, Jeffrey H., Spassov, Danislav S., Hebron, Katie E., Zijlstra, Andries, Moasser, Mark M., Wang, Benlian, Singer, Nora G., Cui, Huadong, Ohara, Ray A., Rasmussen, Stephanie M., Fox, David A., Lin, Feng

“…It has been proposed that CD6, an important regulator of T cells, functions by interacting with its currently identified ligand, CD166, but studies performed…”
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Murine hematopoietic stem cells and multipotent progenitors express truncated intracellular form of c-kit receptor by Zayas, Jennifer, Spassov, Danislav S, Nachtman, Ronald G, Jurecic, Roland

“…The c-kit receptor plays a vital role in self-renewal and differentiation of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). We have…”
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Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain by Ruiz-Saenz, Ana, Zahedi, Farima, Peterson, Elliott, Yoo, Ashley, Dreyer, Courtney A, Spassov, Danislav S, Oses-Prieto, Juan, Burlingame, Alma, Moasser, Mark M

“…The Src family kinases (SFK) are homologs of retroviral oncogenes, earning them the label of proto-oncogenes. Their functions are influenced by positive and…”
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Regulation of inside-out β1-integrin activation by CDCP1 by Pollan, Sara G., Huang, Fangjin, Sperger, Jamie M., Lang, Joshua M., Morrissey, Colm, Cress, Anne E., Chu, C. Y., Bhowmick, Neil A., You, Sungyong, Freeman, Michael R., Spassov, Danislav S., Moasser, Mark M., Carter, William G., Satapathy, Shakti Ranjan, Shah, Kavita, Knudsen, Beatrice S.

“…Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane…”
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A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors by Ruiz-Saenz, Ana, Atreya, Chloe E., Wang, Changjun, Pan, Bo, Dreyer, Courtney A., Brunen, Diede, Prahallad, Anirudh, Muñoz, Denise P., Ramms, Dana J., Burghi, Valeria, Spassov, Danislav S., Fewings, Eleanor, Hwang, Yeonjoo C., Cowdrey, Cynthia, Moelders, Christina, Schwarzer, Cecilia, Wolf, Denise M., Hann, Byron, VandenBerg, Scott R., Shokat, Kevan, Moasser, Mark M., Bernards, René, Gutkind, J. Silvio, van ‘t Veer, Laura J., Coppé, Jean-Philippe

“…Abstract BRAF V600E mutation confers a poor prognosis in metastatic colorectal cancer (CRC) despite combinatorial targeted therapies based on the latest…”
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The PUF Family of RNA‐binding Proteins: Does Evolutionarily Conserved Structure Equal Conserved Function? by Spassov, Danislav, Jurecic, Roland

“…Drosophila Pumilio ( Pum ) protein is a founder member of a novel family of RNA‐binding proteins, known as the PUF family. The PUF proteins constitute an…”
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The Transmembrane src Substrate Trask Is an Epithelial Protein that Signals during Anchorage Deprivation by Spassov, Danislav S, Baehner, Frederick L, Wong, Ching Hang, McDonough, Stephen, Moasser, Mark M

“…The roles of epithelial cells encompass both cellular- and tissue-level functions that involve numerous cell–cell and cell–matrix interactions, which…”
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Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors by Spassov, Danislav S, Jurecic, Roland

“…Self-renewal is the common functional property of all types of stem cells and is thought to be regulated by unknown conserved intrinsic and extrinsic molecular…”
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