Search Results - "SPARLING, P. Frederick"

The Emerging Threat of Untreatable Gonococcal Infection by Bolan, Gail A, Sparling, P. Frederick, Wasserheit, Judith N

“…Gonorrhea, which disproportionately affects marginalized populations, is the second most commonly reported communicable disease in the United States. Over the…”
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Novel Treponema pallidum Serologic Tests: A Paradigm Shift in Syphilis Screening for the 21st Century by Seña, Arlene C., White, Becky L., Sparling, P. Frederick

“…The mainstay of diagnosis for Treponema pallidum infections is based on nontreponemal and treponemal serologic tests. Many new diagnostic methods for syphilis…”
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A doctor's dilemma: choices amidst change by Sparling, P Frederick

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Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome by Duncan, Joseph A, Gao, Xi, Huang, Max Tze-Han, O'Connor, Brian P, Thomas, Christopher E, Willingham, Stephen B, Bergstralh, Daniel T, Jarvis, Gary A, Sparling, P. Frederick, Ting, Jenny P.-Y

“…Neisseria gonorrhoeae is a common sexually transmitted pathogen that significantly impacts female fertility, neonatal health, and transmission of HIV…”
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Vaccines for gonorrhea: can we rise to the challenge? by Zhu, Weiyan, Chen, Ching-Ju, Thomas, Christopher E, Anderson, James E, Jerse, Ann E, Sparling, P Frederick

“…Immune responses to the gonococcus after natural infection ordinarily result in little immunity to reinfection, due to antigenic variation of the gonococcus,…”
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Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men by Hobbs, Marcia M, Anderson, James E, Balthazar, Jacqueline T, Kandler, Justin L, Carlson, Russell W, Ganguly, Jhuma, Begum, Afrin A, Duncan, Joseph A, Lin, Jessica T, Sparling, P Frederick, Jerse, Ann E, Shafer, William M

“…Phosphoethanolamine (PEA) on Neisseria gonorrhoeae lipid A influences gonococcal inflammatory signaling and susceptibility to innate host defenses in in vitro…”
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Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing by Bennett, Julia S, Jolley, Keith A, Sparling, P Frederick, Saunders, Nigel J, Hart, C Anthony, Feavers, Ian M, Maiden, Martin C J

“…Various typing methods have been developed for Neisseria gonorrhoeae, but none provide the combination of discrimination, reproducibility, portability, and…”
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Comparison of Immune Responses to Gonococcal PorB Delivered as Outer Membrane Vesicles, Recombinant Protein, or Venezuelan Equine Encephalitis Virus Replicon Particles by Zhu, Weiyan, Thomas, Christopher E, Chen, Ching-ju, Van Dam, Cornelius N, Johnston, Robert E, Davis, Nancy L, Sparling, P. Frederick

“…Porin (PorB) is a major outer membrane protein produced by all Neisseria gonorrhoeae strains and has been a focus of intense interest as a vaccine candidate…”
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Vaccination of Mice with Gonococcal TbpB Expressed In Vivo from Venezuelan Equine Encephalitis Viral Replicon Particles by Thomas, Christopher E, Zhu, Weiyan, Van Dam, Cornelius N, Davis, Nancy L, Johnston, Robert E, Sparling, P. Frederick

“…We investigated the immunogenicity of gonococcal transferrin binding protein B (TbpB) expressed with and without a eukaryotic secretion signal from a…”
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A Mutant Form of the Neisseria gonorrhoeae Pilus Secretin Protein PilQ Allows Increased Entry of Heme and Antimicrobial Compounds by CHEN, Ching-Ju, TOBIASON, Deborah M, THOMAS, Christopher E, SHAFER, William M, SEIFERT, H. Steven, SPARLING, P. Frederick

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Diagnosis of Neurosyphilis: New Tools by Sparling, P. Frederick

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Experimental Gonococcal Infection in Male Volunteers: Cumulative Experience with Neisseria gonorrhoeae Strains FA1090 and MS11mkC by Hobbs, Marcia M, Sparling, P Frederick, Cohen, Myron S, Shafer, William M, Deal, Carolyn D, Jerse, Ann E

“…Experimental infection of male volunteers with Neisseria gonorrhoeae is safe and reproduces the clinical features of naturally acquired gonococcal urethritis…”
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Point Mutations in HpuB Enable Gonococcal HpuA Deletion Mutants To Grow on Hemoglobin by Chen, Ching-Ju, Mclean, Dalton, Thomas, Christopher E, Anderson, James E, Sparling, P Frederick

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Opposing selective forces for expression of the gonococcal lactoferrin receptor by Anderson, James E., Hobbs, Marcia M., Biswas, Gour D., Sparling, P. Frederick

“…Summary All isolates of Neisseria gonorrhoeae express receptors that bind human transferrin (Tf). Although lactoferrin (Lf) is abundant on mucosa and in…”
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Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens by Cornelissen, C N, Sparling, P F

“…The mechanism of iron utilization from transferrin has been most extensively characterized in the pathogenic Neisseria species and Haemophilus species. Two…”
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Ferric enterobactin binding and utilization by Neisseria gonorrhoeae by Carson, S D, Klebba, P E, Newton, S M, Sparling, P F

“…FetA, formerly designated FrpB, an iron-regulated, 76-kDa neisserial outer membrane protein, shows sequence homology to the TonB-dependent family of receptors…”
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A vaccine for genital HPV: a time to rejoice by Sparling, P Frederick

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2015 Association of American Physicians George M. Kober Lecture: A doctor's dilemma: choices amidst change by Sparling, P Frederick

“…It is a great privilege to deliver the Kober Lecture, which honors the many contributions of the former dean of Georgetown Medical School. George Kober, a…”
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A plethora of host factors that determine the outcome of meningococcal infection by Sparling, P Frederick

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Binding and surface exposure characteristics of the gonococcal transferrin receptor are dependent on both transferrin-binding proteins by Cornelissen, C N, Sparling, P F

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