Search Results - "SPARKS, Lauren M"

Metabolic Flexibility in Health and Disease by Goodpaster, Bret H., Sparks, Lauren M.

“…Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin…”
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human by Wu, Jun, Boström, Pontus, Sparks, Lauren M., Ye, Li, Choi, Jang Hyun, Giang, An-Hoa, Khandekar, Melin, Virtanen, Kirsi A., Nuutila, Pirjo, Schaart, Gert, Huang, Kexin, Tu, Hua, van Marken Lichtenbelt, Wouter D., Hoeks, Joris, Enerbäck, Sven, Schrauwen, Patrick, Spiegelman, Bruce M.

“…Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two…”
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Resistance to the Beneficial Effects of Exercise in Type 2 Diabetes: Are Some Individuals Programmed to Fail? by Stephens, Natalie A, Sparks, Lauren M

“…Context: Exercise benefits most, but not all, individuals with type 2 diabetes (T2D). The beneficial effects are well studied, but why some individuals do not…”
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Precision exercise medicine: understanding exercise response variability by Ross, Robert, Goodpaster, Bret H, Koch, Lauren G, Sarzynski, Mark A, Kohrt, Wendy M, Johannsen, Neil M, Skinner, James S, Castro, Alex, Irving, Brian A, Noland, Robert C, Sparks, Lauren M, Spielmann, Guillaume, Day, Andrew G, Pitsch, Werner, Hopkins, William G, Bouchard, Claude

“…There is evidence from human twin and family studies as well as mouse and rat selection experiments that there are considerable interindividual differences in…”
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Editorial: Exercise intervention for prevention and management of type 2 diabetes by Aguer, Céline, Snigdha, Smiti, Sparks, Lauren M.

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Myokine Secretion following an Aerobic Exercise Intervention in Individuals with Type 2 Diabetes with or without Exercise Resistance by Garneau, Léa, Mulvihill, Erin E, Smith, Steven R, Sparks, Lauren M, Aguer, Céline

“…Type 2 diabetes (T2D) is characterized by muscle metabolic dysfunction that exercise can minimize, but some patients do not respond to an exercise…”
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Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality by De Carvalho, Flavia G, Justice, Jamie N, Freitas, Ellen C de, Kershaw, Erin E, Sparks, Lauren M

“…The interplay between adipose tissue and skeletal muscle and the impact on mobility and aging remain enigmatic. The progressive decline in mobility promoted by…”
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Resistance training to improve type 2 diabetes: working toward a prescription for the future by Pesta, Dominik H, Goncalves, Renata L S, Madiraju, Anila K, Strasser, Barbara, Sparks, Lauren M

“…The prevalence of type 2 diabetes (T2D) is rapidly increasing, and effective strategies to manage and prevent this disease are urgently needed. Resistance…”
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Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans by van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, Williams, Evan G, Ropelle, Eduardo R, Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M, Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B, Hesselink, Matthijs K C, Auwerx, Johan, Roden, Michael, Schrauwen, Patrick

“…Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve…”
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Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels by BOSMA, Madeleen, HESSELINK, Matthijs K. C, KERSTEN, Sander, SCHRAUWEN, Patrick, SPARKS, Lauren M, TIMMERS, Silvie, FERRAZ, Maria Joao, MATTIJSSEN, Frits, BEURDEN, Denis Van, SCHAART, Gert, DE BAETS, Marc H, VERHEYEN, Fons K

“…Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and…”
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Exercise training response heterogeneity: physiological and molecular insights by Sparks, Lauren M.

“…The overall beneficial effects of exercise are well studied, but why some people do not respond favourably to exercise is less understood. The National…”
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Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults by Rubenstein, Aliza B, Hinkley, J Matthew, Nair, Venugopalan D, Nudelman, German, Standley, Robert A, Yi, Fanchao, Yu, GongXin, Trappe, Todd A, Bamman, Marcas M, Trappe, Scott W, Sparks, Lauren M, Goodpaster, Bret H, Vega, Rick B, Sealfon, Stuart C, Zaslavsky, Elena, Coen, Paul M

“…Age-related declines in cardiorespiratory fitness and physical function are mitigated by regular endurance exercise in older adults. This may be due, in part,…”
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Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women by Garneau, Léa, Parsons, Stephanie A, Smith, Steven R, Mulvihill, Erin E, Sparks, Lauren M, Aguer, Céline

“…Exercise and physical activity levels influence myokine release from skeletal muscle and contribute to circulating concentrations. Indeed, many myokines,…”
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A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle by SPARKS, Lauren M, HUI XIE, KOZA, Robert A, MYNATT, Randall, HULVER, Matthew W, BRAY, George A, SMITH, Steven R

“…A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle Lauren M. Sparks , Hui Xie , Robert A…”
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Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans by Nascimento, Emmani B.M., Sparks, Lauren M., Divoux, Adeline, van Gisbergen, Marike W., Broeders, Evie P.M., Jörgensen, Johanna A., Schaart, Gert, Bouvy, Nicole D., van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick

“…Objective Human brown adipose tissue (BAT) activity decreases with age and obesity. In addition to uncoupling protein 1 (UCP1), several genetic markers of BAT…”
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PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans by Koves, Timothy R., Sparks, Lauren M., Kovalik, J.P., Mosedale, Merrie, Arumugam, Ramamani, DeBalsi, Karen L., Everingham, Karen, Thorne, Leigh, Phielix, Esther, Meex, Ruth C., Kien, C. Lawrence, Hesselink, Matthijs K.C., Schrauwen, Patrick, Muoio, Deborah M.

“…Intramuscular accumulation of triacylglycerol, in the form of lipid droplets (LD), has gained widespread attention as a hallmark of metabolic disease and…”
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The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria by Bosma, Madeleen, Minnaard, Ronnie, Sparks, Lauren M., Schaart, Gert, Losen, Mario, de Baets, Marc H., Duimel, Hans, Kersten, Sander, Bickel, Perry E., Schrauwen, Patrick, Hesselink, Matthijs K. C.

“…Perilipin 5 (PLIN5/OXPAT) is a lipid droplet (LD) coat protein mainly present in tissues with a high fat-oxidative capacity, suggesting a role for PLIN5 in…”
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Targeting White Adipose Tissue with Exercise or Bariatric Surgery as Therapeutic Strategies in Obesity by Giolo De Carvalho, Flávia, Sparks, Lauren M

“…Adipose tissue is critical to whole-body energy metabolism and has become recognized as a bona fide endocrine organ rather than an inert lipid reservoir. As…”
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Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue by Willows, Jake W., Gunsch, Gilian, Paradie, Emma, Blaszkiewicz, Magdalena, Tonniges, Jeffrey R., Pino, Maria F., Smith, Steven R., Sparks, Lauren M., Townsend, Kristy L.

“…Peripheral neuropathy, which can include axonal degeneration and/or demyelination, impacts adipose tissues with obesity, diabetes, and aging. However, the…”
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Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults by Brennan, Andrea M, Standley, Robert A, Yi, Fanchao, Carnero, Elvis A, Sparks, Lauren M, Goodpaster, Bret H

“…Weight loss induced by decreased energy intake (diet) or exercise generally has favorable effects on insulin sensitivity and cardiometabolic risk. The…”
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