Search Results - "SPAN, Simone W"

Global Histone Modifications Predict Prognosis of Resected Non–Small-Cell Lung Cancer by Barlési, Fabrice, Giaccone, Giuseppe, Gallegos-Ruiz, Marielle I, Loundou, Anderson, Span, Simone W, Lefesvre, Pierre, Kruyt, Frank A E, Rodriguez, Jose Antonio

“…Epigenetic modifications may contribute to the development and progression of cancer. We investigated whether epigenetic changes involving multiple histones…”
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Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells by BROKER, Linda E, HUISMAN, Cynthia, SPAN, Simone W, RODRIGUEZ, José A, KRUYT, Frank A. E, GIACCONE, Giuseppe

“…We have previously reported that the microtubule stabilizing agents (MSAs) paclitaxel, epothilone B and discodermolide induce caspase-independent cell death in…”
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CRM1-Mediated Nuclear Export Determines the Cytoplasmic Localization of the Antiapoptotic Protein Survivin by Rodríguez, Jose A., Span, Simone W., Ferreira, Carlos G.M., Kruyt, Frank A.E., Giaccone, Giuseppe

“…Survivin is a member of the inhibitor of apoptosis (IAP) family of negative regulators of programmed cell death that is frequently overexpressed in human…”
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Nuclear shuttling and TRAF2-mediated retention in the cytoplasm regulate the subcellular localization of cIAP1 and cIAP2 by Vischioni, Barbara, Giaccone, Giuseppe, Span, Simone W, Kruyt, Frank A.E, Rodriguez, Jose A

“…Dynamic subcellular localization is an important regulatory mechanism for many proteins. cIAP1 and cIAP2 are two closely related members of inhibitor of…”
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The Expression of TUCAN, an Inhibitor of Apoptosis Protein, in Patients with Advanced Non-small Cell Lung Cancer Treated with Chemotherapy by CHECINSKA, Agnieszka, OUDEJANS, Joost J, SPAN, Simone W, RODRIGUEZ, Jose A, KRUYT, Frank A. E, GIACCONE, Giuseppe

“…Background: TUCAN is a caspase recruitment domain (CARD)-containing protein involved in tumor biology by regulating apoptosis and the NFκB pathway. Inhibition…”
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Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres by Lens, Susanne M A, Rodriguez, Jose A, Vader, Gerben, Span, Simone W, Giaccone, Giuseppe, Medema, René H

“…Survivin is a component of the chromosomal passenger complex (CPC) that plays a role in maintenance of an active spindle checkpoint and in cytokinesis. To…”
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Expression and localization of inhibitor of apoptosis proteins in normal human tissues by Vischioni, Barbara, van der Valk, Paul, Span, Simone W., Kruyt, Frank A.E., Rodriguez, Jose A., Giaccone, Giuseppe

“…The family of inhibitor of apoptosis (IAP) proteins can suppress apoptosis induced by a variety of triggers. Among the IAPs, cIAP1, cIAP2, and XIAP have been…”
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Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients by FERREIRA, Carlos G, VAN DER VALK, Paul, SPAN, Simone W, LUDWIG, Inge, SMIT, Egbert F, KRUYT, Frank A. E, PINEDO, Herbert M, VAN TINTEREN, Harm, GIACCONE, Giuseppe

“…Purpose: To assess the pattern of expression and the prognostic value of the inhibitor of apoptosis family member X-linked inhibitor of apoptosis (XIAP;…”
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Genotype analysis of the VNTR polymorphism in the SMYD3 histone methyltransferase gene: Lack of correlation with the level of histone H3 methylation in NSCLC tissues or with the risk of NSCLC by Barlési, Fabrice, Giaccone, Giuseppe, Gallegos‐Ruiz, Marielle I., Span, Simone W., Lefesvre, Pierre, Kruyt, Frank A.E., Rodriguez, Jose Antonio

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Drug-induced Apoptosis in Lung Cancer Cells Is Not Mediated by the Fas/FasL (CD95/APO1) Signaling Pathway by FERREIRA, C. G, TOLIS, C, SPAN, S. W, PETERS, G. J, VAN LOPIK, T, KUMMER, A. J, PINEDO, H. M, GIACCONE, G

“…Anticancer drugs exert at least part of their cytotoxic effect by triggering apoptosis. We previously identified chemotherapy-induced apoptosis in lung cancer…”
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Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins by Rodriguez, Jose A, Span, Simone W, Kruyt, Frank A E, Giaccone, Giuseppe

“…The cowpox virus-encoded anti-apoptotic protein cytokine response modifier A (CrmA) is a member of the serpin family that specifically inhibits the cellular…”
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Cisplatin triggers apoptotic or nonapoptotic cell death in Fanconi anemia lymphoblasts in a concentration-dependent manner by Ferrer, Miriam, Izeboud, Thijs, Ferreira, Carlos G, Span, Simone W, Giaccone, Giuseppe, Kruyt, Frank A.E

“…Cells derived from Fanconi anemia (FA) patients are hypersensitive for cross-linking agents, such as cisplatin, that are potent inducers of programmed cell…”
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FANCD2 Expression in Advanced Non–Small-Cell Lung Cancer and Response to Platinum-Based Chemotherapy by Ferrer, Miriam, Span, Simone W., Vischioni, Barbara, Oudejans, Joost J., van Diest, Paul J., de Winter, Johan P., Giaccone, Giuseppe, Kruyt, Frank A.E.

“…Fanconi's anemia (FA) is a genetically heterogeneous disease characterized by cancer susceptibility and hypersensitivity to cross-linking agents such as…”
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Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460 by Ferreira, C G, Span, S W, Peters, G J, Kruyt, F A, Giaccone, G

“…Chemotherapy-induced apoptosis is generally thought to be dependent on a pathway headed by caspase-9. This model is primarily based on studies performed in…”
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Uncoupling the Central Spindle-associated Function of the Chromosomal Passenger Complex from Its Role at CentromeresD by Lens, Susanne M.A., Rodriguez, Jose A., Vader, Gerben, Span, Simone W., Giaccone, Giuseppe, Medema, René H.

“…Survivin is a component of the chromosomal passenger complex (CPC) that plays a role in maintenance of an active spindle checkpoint and in cytokinesis. To…”
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Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCl-H460 by FERREIRA, Carlos G, SPAN, Simone W, PETERS, Godefridus J, KRUYT, Frank A. E, GIACCONE, Giuseppe

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