Search Results - "SPALDING, Judson W"

The Tg.AC (v-Ha-ras) Transgenic Mouse: Nature of the Model by Tennant, Raymond W., Stasiewicz, Stanley, Eastin, William C., Mennear, John H., Spalding, Judson W.

“…The Tg.AC (v-Ha-ras) transgenic mouse model provides a reporter phenotype of skin papillomas in response to either genotoxic or nongenotoxic carcinogens. In…”
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Tg.AC Genetically Altered Mouse: Assay Working Group Overview of Available Data by Eastin, William C., Mennear, John H., Tennant, Ray W., Stoll, Ray E., Branstetter, Dan G., Bucher, John R., Mccullough, Bruce, Binder, Robert L., Spalding, Judson W., Mahler, Joel F.

“…In a Government/Industry/Academic partnership to evaluate alternative approaches to carcinogenicity testing, 21 pharmaceutical agents representing a variety of…”
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THE USE OF TRANSGENIC ANIMALS IN CANCER TESTING by French, J E, Spalding, J W, Dunnick, J K, Tice, R R, Furedi-Machacek, M, Tennant, R W

“…The emergence of transgenic technology has provided a new and potentially useful set of tools for carcinogen identification. To this end, several transgenic…”
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Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review by HUMBLE, Michael C, TREMPUS, Carol S, SPALDING, Judson W, CANNON, Ronald E, TENNANT, Raymond W

“…The genetically initiated Tg.AC transgenic mouse carries a transgene consisting of an oncogenic v-Ha-ras coding region flanked 5' by a mouse zeta-globin…”
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Transformation of BALB/c-3T3 Cells: V. Transformation Responses of 168 Chemicals Compared with Mutagenicity in Salmonella and Carcinogenicity in Rodent Bioassays by Matthews, Edwin J., Spalding, Judson W., Tennant, Raymond W.

“…This report describes the activities of 168 chemicals tested in a standard transformation assay using A-31-1-13 BALB/c-3T3 cells. The data set includes 84…”
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Kinetics of wound-induced v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice by Cannon, Ronald E., Spalding, Judson W., Trempus, Carol S., Szczesniak, Carl J., Virgil, Kelly M., Humble, Michael C., Tennant, Raymond W.

“…The Tg.AC transgenic mouse, which harbors an activated v‐Ha‐ras coding region that is fused to an embryonic ζ globin transcriptional control region and a 3′…”
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The transgenic Tg.AC mouse model for identification of chemical carcinogens by Tennant, Raymond W, Tice, Raymond R, Spalding, Judson W

“…The Tg.AC (zetaglobin promoted v-Ha-ras) transgenic mouse is being evaluated as a short-term carcinogenicity bioassay. In order to harmonize the evaluation…”
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Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin by OWENS, D. M, SPALDING, J. W, TENNANT, R. W, SMART, R. C

“…TG.AC transgenic mice harbor a v-Ha-ras transgene and retain two normal c-Ha-ras alleles and are susceptible to skin tumor formation by…”
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Oral administration of dimethylvinyl chloride increases frequency of forestomach papillomas in Tg.AC mice by Cannon, Ronald E., Graves, Samantha, Spalding, Judson W., Trempus, Carol S., Tennant, Raymond W.

“…This work was initiated to determine the potential for the Tg.AC mouse model to identify chemical carcinogens by an oral route of administration. Tg.AC…”
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Transformation of BALB/c-3T3 Cells: IV. Rank-Ordered Potency of 24 Chemical Responses Detected in a Sensitive New Assay Procedure by Matthews, Edwin J., Spalding, Judson W., Tennant, Raymond W.

“…This report introduces an improved method of detecting chemical-induced morphological transformation of A-31-1-13 BALB/c-3T3 cells. The new procedure uses an…”
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Morphological characterization of spindle cell tumors induced in transgenic Tg.AC mouse skin by Asano, S, Trempus, C S, Spalding, J W, Tennant, R W, Battalora, M S

“…Transgenic Tg.AC mice carry a v-Ha-ras coding region flanked by a zeta-globin promoter and an SV40 polyadenylation signal sequence. These mice respond to…”
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Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse by Battalora, Michael StJ, Spalding, Judson W., Szczesniak, Carl J., Cape, James E., Morris, Rebecca J., Trempus, Carol S., Bortner, Carl D., Lee, Byung M., Tennant, Raymond W.

“…Transgenic Tg.AC (v-Ha-ras ) mice develop skin tumors in response to specific carcinogens and tumor promoters. The Tg.AC mouse carries the coding sequence of…”
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Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene by Steinmetz, K L, Tyson, C K, Meierhenry, E F, Spalding, J W, Mirsalis, J C

“…The antihistamine methapyrilene (MP) was widely used as a component of cold, allergy and sleep-aid medications in the 1970s until it was identified as a potent…”
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Induction of hepatic cell proliferation and unscheduled DNA synthesis in mouse hepatocytes following in vivo treatment by Mirsalis, J C, Tyson, C K, Loh, E N, Steinmetz, K L, Bakke, J P, Hamilton, C M, Spak, D K, Spalding, J W

“…We have modified the in vivo-in vitro hepatocyte DNA repair assay for measurement of unscheduled DNA synthesis (UDS) and hepatic cell proliferation in B6C3F1…”
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Responses of Transgenic Mouse Lines p53+/− and Tg•AC to Agents Tested in Conventional Carcinogenicity Bioassays by Spalding, Judson W., French, John E., Stasiewicz, Stanley, Furedi-Machacek, Marianna, Conner, Fawn, Tice, Raymond R., Tennant, Raymond W.

“…The haplo-insufficient p53 knockout (p53+/−) and zetaglobin v-Ha-ras (Tg•AC) transgenic mouse models were compared to the conventional two rodent species…”
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Identifying Chemical Carcinogens and Assessing Potential Risk in Short-Term Bioassays Using Transgenic Mouse Models by Tennant, Raymond W., French, John E., Spalding, Judson W.

“…Cancer is a worldwide public health concern. Identifying carcinogens and limiting their exposure is one approach to the problem of reducing risk. Currently,…”
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Development of a transgenic mouse model for carcinogenesis bioassays : Evaluation of chemically induced skin tumors in Tg.AC mice by SPALDING, J. W, FRENCH, J. E, TICE, R. R, FUREDI-MACHACEK, M, HASEMAN, J. K, TENNANT, R. W

“…Transgenic rodent models have emerged as potentially useful tools in the assessment of drug and chemical safety. The transgenic Tg.AC mouse carries an…”
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Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene by Spalding, J W, Momma, J, Elwell, M R, Tennant, R W

“…A transgenic mouse line (TG.AC) created in the FVB/N strain, carries a v-Ha-ras gene fused to a zeta-globin promoter gene. These trangenic mice have the…”
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Comparative expression of novel vascular endothelial growth factor/vascular permeability factor transcripts in skin, papillomas, and carcinomas of v-Ha-ras Tg.AC transgenic mice and FVB/N mice by Tober, K L, Cannon, R E, Spalding, J W, Oberyszyn, T M, Parrett, M L, Rackoff, A I, Oberyszyn, A S, Tennant, R W, Robertson, F M

“…One of the most frequently detected changes in human solid tumors is the mutation of the ras oncogene, which has been associated with production of angiogenic…”
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Comparative Expression of Novel Vascular Endothelial Growth Factor/Vascular Permeability Factor Transcripts in Skin, Papillomas, and Carcinomas of v-Ha- rasTg.AC Transgenic Mice and FVB/N Mice by Tober, Kathleen L., Cannon, Ronald E., Spalding, Judson W., Oberyszyn, Tatiana M., Parrett, Michelle L., Rackoff, Andrew I., Oberyszyn, Andrew S., Tennant, Raymond W., Robertson, Fredika M.

“…One of the most frequently detected changes in human solid tumors is the mutation of the rasoncogene, which has been associated with production of angiogenic…”
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