Search Results - "SOWA, YOSHIHIRO"

Prophylactic Application of Human Adipose Tissue–Derived Products to Prevent Radiation Disorders by Sowa, Yoshihiro, Inafuku, Naoki, Kishida, Tsunao, Mori, Masanori, Mazda, Osam, Yoshimura, Kotaro

“…Radiation therapy is a mainstay treatment for malignancies, but it can induce deterministic adverse effects in surrounding healthy tissues, including atrophy,…”
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Molecular‐targeting therapies against quantitative abnormalities in gene expression with malignant tumors by Sakai, Toshiyuki, Sowa, Yoshihiro

“…Genetic mutations in exons of oncogenes and tumor‐suppressor genes causing qualitative abnormalities result in activation of the oncogenes and inactivation of…”
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A Medical Tattooing Technique for Enhancing the Three-Dimensional Appearance of the Nipple-Areola Complex After Flap-Based Nipple Reconstruction by Sowa, Yoshihiro, Kodama, Takuya, Hori, Tomoko, Numajiri, Toshiaki

“…Introduction Medical tattooing is a critical reconstructive component in the surgical process for good esthetic outcomes and improved patient satisfaction…”
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Involvement of PDGF-BB and IGF-1 in Activation of Human Schwann Cells by Platelet-Rich Plasma by Sowa, Yoshihiro, Kishida, Tsunao, Tomita, Koichi, Adachi, Tetsuya, Numajiri, Toshiaki, Mazda, Osam

“…BACKGROUND:Platelet-rich plasma (PRP) contains high concentrations of growth factors that stimulate proliferation and migration of various cell types. Earlier…”
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Adipose-derived stem cells produce factors enhancing peripheral nerve regeneration: influence of age and anatomic site of origin by Sowa, Yoshihiro, Imura, Tetsuya, Numajiri, Toshiaki, Nishino, Kenichi, Fushiki, Shinji

“…Adipose-derived stem cells (ADSCs) are attracting increased attention as a novel source in regenerative medicine. Transplantation of ADSCs promotes functional…”
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Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells by Tanaka, Ryoichi, Tomosugi, Mitsuhiro, Horinaka, Mano, Sowa, Yoshihiro, Sakai, Toshiyuki

“…Although many chemotherapeutic strategies against cancer have been developed, pancreatic cancer is one of the most aggressive and intractable types of…”
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Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS‐mutated ovarian cancer cells with high AXL expression by Umemura, Shiori, Sowa, Yoshihiro, Iizumi, Yosuke, Kitawaki, Jo, Sakai, Toshiyuki

“…KRAS mutation is frequently seen in a subtype of ovarian cancer categorized as type 1. The KRAS‐MAPK pathway, which is closely involved in type 1 cancer…”
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Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)‐reactivating agents enhance efficacy of 5‐fluorouracil on human colon cancer cells by Watanabe, Motoki, Sowa, Yoshihiro, Yogosawa, Mayumi, Sakai, Toshiyuki

“…Chemotherapy for colorectal cancer has become more complicated and diversified with the appearance of molecular‐targeting agents. 5‐Fluorouracil (5‐FU) has…”
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Involvement of cyclin D and p27 in cell proliferation mediated by ROCK inhibitors Y-27632 and Y-39983 during corneal endothelium wound healing by Okumura, Naoki, Nakano, Shinichiro, Kay, EunDuck P, Numata, Ryohei, Ota, Aya, Sowa, Yoshihiro, Sakai, Toshiyuki, Ueno, Morio, Kinoshita, Shigeru, Koizumi, Noriko

“…To investigate the molecular mechanism of Rho-associated kinase (ROCK) inhibitors Y-27632 and Y-39983 on corneal endothelial cell (CEC) proliferation and their…”
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Adipose-Derived Stem Cells Promote Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells In Vitro by Secreting Lymphangiogenic Factors by Takeda, Kohsuke, Sowa, Yoshihiro, Nishino, Kenichi, Itoh, Kyoko, Fushiki, Shinji

“…ABSTRACTAdipose-derived stem cells (ADSCs) are a promising new therapeutic modality for several diseases and have been applied to various clinical fields…”
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Micronized Cellular Adipose Matrix Promotes the Therapeutic Effect of an Artificial Nerve Conduit in Peripheral Nerve Gap Injury by Sawai, Seiji, Sowa, Yoshihiro, Kishida, Tsunao, Inokawa, Hitoshi, Inafuku, Naoki, Tsuchida, Shinji, Oda, Ryo, Fujiwara, Hiroyoshi, Mazda, Osam, Yoshimura, Kotaro, Takahashi, Kenji

“…Stromal vascular fraction (SVF) isolated from adipose tissue has been shown to be beneficial for treating peripheral nerve injuries. Micronized cellular…”
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Reply: Involvement of PDGF-BB and IGF-1 in Activation of Human Schwann Cells by Platelet-Rich Plasma by Sowa, Yoshihiro, Kishida, Tsunao, Tomita, Koichi, Adachi, Tetsuya, Numajiri, Toshiaki, Mazda, Osam

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Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells by Ichikawa, Masami, Sowa, Yoshihiro, Iizumi, Yosuke, Aono, Yuichi, Sakai, Toshiyuki

“…Huachansu, a traditional Chinese medicine prepared from the dried toad skin, has been used in clinical studies for various cancers in China. Resibufogenin is a…”
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A novel approach for wound treatment using dried cultured epidermal allograft: A phase I/II, single-center, open-label clinical trial by Sakamoto, Michiharu, Minaki, Yasuko, Nakano, Takashi, Tsuge, Itaru, Yamanaka, Hiroki, Sowa, Yoshihiro, Shimizu, Yoshihiro, Inoie, Masukazu, Saito, Susumu, Morimoto, Naoki

“…Autologous cultured epidermis (CE) is successfully used in burn care, but it requires a manufacturing time of three weeks and is very expensive owing to its…”
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Injectable Prevascularized Mature Adipose Tissues (iPAT) to Achieve Long‐Term Survival in Soft Tissue Regeneration by Louis, Fiona, Sowa, Yoshihiro, Irie, Shinji, Higuchi, Yuriko, Kitano, Shiro, Mazda, Osam, Matsusaki, Michiya

“…Soft tissue regeneration remains a challenge in reconstructive surgery. So far, both autologous fat implantations and artificial implants methods used in…”
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Adipose stromal cells contain phenotypically distinct adipogenic progenitors derived from neural crest by Sowa, Yoshihiro, Imura, Tetsuya, Numajiri, Toshiaki, Takeda, Kosuke, Mabuchi, Yo, Matsuzaki, Yumi, Nishino, Kenichi

“…Recent studies have shown that adipose-derived stromal/stem cells (ASCs) contain phenotypically and functionally heterogeneous subpopulations of cells, but…”
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Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer by Wilson, Andrew J., Byun, Do-Sun, Popova, Natalia, Murray, Lucas B., L'Italien, Kaitlin, Sowa, Yoshihiro, Arango, Diego, Velcich, Anna, Augenlicht, Leonard H., Mariadason, John M.

“…Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis of colon cancer cell lines in vitro and have demonstrated…”
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High-throughput drug screening models of mature adipose tissues which replicate the physiology of patients’ Body Mass Index (BMI) by Louis, Fiona, Sowa, Yoshihiro, Kitano, Shiro, Matsusaki, Michiya

“…Obesity is a complex and incompletely understood disease, but current drug screening strategies mostly rely on immature in vitro adipose models which cannot…”
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Cationic polymer effect on brown adipogenic induction of dedifferentiated fat cells by Karanfil, Aslı Sena, Louis, Fiona, Sowa, Yoshihiro, Matsusaki, Michiya

“…Obesity and its associated comorbidities place a substantial burden on public health. Given the considerable potential of brown adipose tissue in addressing…”
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Risk factors associated with chronic pain after mastectomy: a prospective study with a 5-year follow-up in Japan by Shiraishi, Makoto, Sowa, Yoshihiro, Tsuge, Itaru, Shiraishi, Akiko, Inafuku, Naoki, Nakayama, Ichiro, Morimoto, Naoki

“…Background Chronic pain is a major complication following breast surgery including breast reconstruction. We previously examined prospective patient-specific…”
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