Search Results - "SOUTHWOOD, Mark"

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension by Gräf, Stefan, Haimel, Matthias, Bleda, Marta, Hadinnapola, Charaka, Southgate, Laura, Li, Wei, Hodgson, Joshua, Liu, Bin, Salmon, Richard M., Southwood, Mark, Machado, Rajiv D., Martin, Jennifer M., Treacy, Carmen M., Yates, Katherine, Daugherty, Louise C., Shamardina, Olga, Whitehorn, Deborah, Holden, Simon, Aldred, Micheala, Bogaard, Harm J., Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A., Danesino, Cesare, Eyries, Mélanie, Gall, Henning, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J. Simon R., Girerd, Barbara, Houweling, Arjan C., Howard, Luke, Humbert, Marc, Kiely, David G., Kovacs, Gabor, MacKenzie Ross, Robert V., Moledina, Shahin, Montani, David, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Peacock, Andrew J., Pepke-Zaba, Joanna, Prokopenko, Inga, Rhodes, Christopher J., Scelsi, Laura, Seeger, Werner, Soubrier, Florent, Stein, Dan F., Suntharalingam, Jay, Swietlik, Emilia M., Toshner, Mark R., van Heel, David A., Vonk Noordegraaf, Anton, Waisfisz, Quinten, Wharton, John, Wort, Stephen J., Ouwehand, Willem H., Soranzo, Nicole, Lawrie, Allan, Upton, Paul D., Wilkins, Martin R., Trembath, Richard C., Morrell, Nicholas W.

“…Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious variation within components of the transforming growth factor-β…”
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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension by Yang, Peiran, Read, Cai, Kuc, Rhoda E, Buonincontri, Guido, Southwood, Mark, Torella, Rubben, Upton, Paul D, Crosby, Alexi, Sawiak, Stephen J, Carpenter, T Adrian, Glen, Robert C, Morrell, Nicholas W, Maguire, Janet J, Davenport, Anthony P

“…BACKGROUND:Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor, despite lack of sequence…”
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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling by Hurst, Liam A., Dunmore, Benjamin J., Long, Lu, Crosby, Alexi, Al-Lamki, Rafia, Deighton, John, Southwood, Mark, Yang, Xudong, Nikolic, Marko Z., Herrera, Blanca, Inman, Gareth J., Bradley, John R., Rana, Amer A., Upton, Paul D., Morrell, Nicholas W.

“…Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH)…”
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Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation by Long, Lu, Yang, Xudong, Southwood, Mark, Lu, Junyu, Marciniak, Stefan J, Dunmore, Benjamin J, Morrell, Nicholas W

“…RATIONALE:Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation and apoptosis resistance in pulmonary artery smooth muscle cells…”
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Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice by Li, Wei, Long, Lu, Yang, Xudong, Tong, Zhen, Southwood, Mark, King, Ross, Caruso, Paola, Upton, Paul D, Yang, Peiran, Bocobo, Geoffrey A, Nikolic, Ivana, Higuera, Angelica, Salmon, Richard M, Jiang, He, Lodge, Katharine M, Hoenderdos, Kim, Baron, Rebecca M, Yu, Paul B, Condliffe, Alison M, Summers, Charlotte, Nourshargh, Sussan, Chilvers, Edwin R, Morrell, Nicholas W

“…Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating…”
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Evidence for the Involvement of Type I Interferon in Pulmonary Arterial Hypertension by George, Peter M., Oliver, Eduardo, Dorfmuller, Peter, Dubois, Olivier D., Reed, Daniel M., Kirkby, Nicholas S., Mohamed, Nura A., Perros, Frederic, Antigny, Fabrice, Fadel, Elie, Schreiber, Benjamin E., Holmes, Alan M., Southwood, Mark, Hagan, Guy, Wort, Stephen J., Bartlett, Nathan, Morrell, Nicholas W., Coghlan, John G., Humbert, Marc, Zhao, Lan, Mitchell, Jane A.

“…RATIONALE:Evidence is increasing of a link between interferon (IFN) and pulmonary arterial hypertension (PAH). Conditions with chronically elevated endogenous…”
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Proteomic Analysis Implicates Translationally Controlled Tumor Protein as a Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension by Lavoie, Jessie R, Ormiston, Mark L, Perez-Iratxeta, Carol, Courtman, David W, Jiang, Baohua, Ferrer, Elisabet, Caruso, Paola, Southwood, Mark, Foster, William S, Morrell, Nicholas W, Stewart, Duncan J

“…BACKGROUND—Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation of pulmonary vascular endothelial cells (ECs)…”
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Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension by Toshner, Mark, Voswinckel, Robert, Southwood, Mark, Al-Lamki, Rafia, Howard, Luke S. G, Marchesan, Denis, Yang, Jun, Suntharalingam, Jay, Soon, Elaine, Exley, Andrew, Stewart, Susan, Hecker, Markus, Zhu, Zhenping, Gehling, Ursula, Seeger, Werner, Pepke-Zaba, Joanna, Morrell, Nicholas W

“…Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary…”
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Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma by Farahi, Neda, Paige, Ellie, Balla, Jozef, Prudence, Emily, Ferreira, Ricardo C, Southwood, Mark, Appleby, Sarah L, Bakke, Per, Gulsvik, Amund, Litonjua, Augusto A, Sparrow, David, Silverman, Edwin K, Cho, Michael H, Danesh, John, Paul, Dirk S, Freitag, Daniel F, Chilvers, Edwin R

“…The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other…”
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Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension by ORMISTON, Mark L, CHIWEN CHANG, SOUTHWOOD, Mark, PEPKE-ZABA, Joanna, EXLEY, Andrew, TREMBATH, Richard C, COLUCCI, Francesco, WILLS, Mark, TROWSDALE, John, MORRELL, Nicholas W, LONG, Lu L, SOON, Elaine, JONES, Des, MACHADO, Rajiv, TREACY, Carmen, TOSHNER, Mark R, CAMPBELL, Kate, RIDING, Alex

“…Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary…”
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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension by Arnold, Nadine D., Pickworth, Josephine A., West, Laura E., Dawson, Sarah, Carvalho, Joana A., Casbolt, Helen, Braithwaite, Adam T., Iremonger, James, Renshall, Lewis, Germaschewski, Volker, McCourt, Matthew, Bland-Ward, Philip, Kowash, Hager, Hameed, Abdul G., Rothman, Alexander M. K., Frid, Maria G., Roger Thompson, A. A., Evans, Holly R., Southwood, Mark, Morrell, Nicholas W., Crossman, David C., Whyte, Moira K. B., Stenmark, Kurt R., Newman, Christopher M., Kiely, David G., Francis, Sheila E., Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive…”
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Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension by CAHILL, Edwina, COSTELLO, Christine M, MORRELL, Nicholas W, MARTIN, Finian, MCLOUGHLIN, Paul, ROWAN, Simon C, HARKIN, Susan, HOWELL, Katherine, LEONARD, Martin O, SOUTHWOOD, Mark, CUMMINS, Eoin P, FITZPATRICK, Susan F, TAYLOR, Cormac T

“…Pulmonary hypertension occurs in chronic hypoxic lung diseases, significantly worsening morbidity and mortality. The important role of altered bone…”
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Hepatic Shunting of Eggs and Pulmonary Vascular Remodeling in Bmpr2(+/-) Mice with Schistosomiasis by Crosby, Alexi, Soon, Elaine, Jones, Frances M, Southwood, Mark R, Haghighat, Leila, Toshner, Mark R, Raine, Tim, Horan, Ian, Yang, Peiran, Moore, Stephen, Ferrer, Elisabet, Wright, Penny, Ormiston, Mark L, White, R James, Haight, Deborah A, Dunne, David W, Morrell, Nicholas W

“…Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH). Mutations in the bone morphogenetic protein type-II receptor (BMPR-II) are the…”
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Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells by Toshner, Mark, Dunmore, Benjamin J, McKinney, Eoin F, Southwood, Mark, Caruso, Paola, Upton, Paul D, Waters, John P, Ormiston, Mark L, Skepper, Jeremy N, Nash, Gerard, Rana, Amer A, Morrell, Nicholas W

“…The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming…”
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Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension by Yang, Xudong, Long, Lu, Southwood, Mark, Rudarakanchana, Nung, Upton, Paul D, Jeffery, Trina K, Atkinson, Carl, Chen, Hailan, Trembath, Richard C, Morrell, Nicholas W

“…Mutations in the bone morphogenetic protein type II receptor gene (BMPR2) are the major genetic cause of familial pulmonary arterial hypertension (FPAH)…”
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HIF isoforms in the skin differentially regulate systemic arterial pressure by Cowburn, Andrew S., Takeda, Norihiko, Boutin, Adam T., Kim, Jung-Whan, Sterling, Jane C., Nakasaki, Manando, Southwood, Mark, Goldrath, Ananda W., Jamora, Colin, Nizet, Victor, Chilvers, Edwin R., Johnson, Randall S.

“…Vascular flow through tissues is regulated via a number of homeostatic mechanisms. Localized control of tissue blood flow, or autoregulation, is a key factor…”
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Endothelin ET A receptors predominate in chronic thromboembolic pulmonary hypertension by Southwood, Mark, MacKenzie Ross, Robert V., Kuc, Rhoda E., Hagan, Guy, Sheares, Karen K., Jenkins, David P., Goddard, Martin, Davenport, Anthony P., Pepke-Zaba, Joanna

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Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer by Southwood, Mark, Krenz, Tomasz, Cant, Natasha, Maurya, Manisha, Gazdova, Jana, Maxwell, Perry, McGready, Claire, Moseley, Ellen, Hughes, Susan, Stewart, Peter, Salto‐Tellez, Manuel, Groelz, Daniel, Rassl, Doris

“…Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove…”
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A Practical and Efficient Cellular Substrate for the Generation of Induced Pluripotent Stem Cells from Adults: Blood‐Derived Endothelial Progenitor Cells by Geti, Imbisaat, Ormiston, Mark L., Rouhani, Foad, Toshner, Mark, Movassagh, Mehregan, Nichols, Jennifer, Mansfield, William, Southwood, Mark, Bradley, Allan, Rana, Amer Ahmed, Vallier, Ludovic, Morrell, Nicholas W.

“…This report describes the use of late‐outgrowth endothelial progenitor cells (L‐EPCs), as a cellular substrate for the generation of induced pluripotent stem…”
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A Role for Complement in the Enhanced Susceptibility of Steatotic Livers to Ischemia and Reperfusion Injury by He, Songqing, Atkinson, Carl, Evans, Zachary, Ellett, Justin D, Southwood, Mark, Elvington, Andrew, Chavin, Kenneth D, Tomlinson, Stephen

“…Hepatic steatosis typically renders the donor organ unusable, as donor organs with >30% steatosis are more likely to develop graft failure. The mechanisms…”
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