Search Results - "SOULIOTIS, V. L"

Correction: Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma by Gkotzamanidou, M., Sfikakis, P. P., Kyrtopoulos, S. A., Bamia, C., Dimopoulos, M. A., Souliotis, V. L.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis by Sfikakis, P.P, Souliotis, V.L, Fragiadaki, K.G, Moutsopoulos, H.M, Boletis, J.N, Theofilopoulos, A.N

“…Abstract B cell depletion may affect T cell activation and costimulation status in rituximab-treated patients with SLE. We examined whether rituximab…”
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Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma by Gkotzamanidou, M, Sfikakis, P P, Kyrtopoulos, S A, Bamia, C, Dimopoulos, M A, Souliotis, V L

“…Background: Melphalan is one of the most active chemotherapeutic agents in the treatment of multiple myeloma (MM). However, the mechanism underlying…”
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Increased DNA double-strand breaks and enhanced apoptosis in patients with lupus nephritis by Souliotis, V L, Sfikakis, P P

“…Objective DNA double-strand breaks (DSBs) lead to mutations, genomic instability and apoptotic death, whereas accumulation of apoptotic cells results in…”
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The DNA damage response network in the treatment of head and neck squamous cell carcinoma by Psyrri, A., Gkotzamanidou, M., Papaxoinis, G., Krikoni, L., Economopoulou, P., Kotsantis, I., Anastasiou, M., Souliotis, V.L.

“…We sought to determine whether DNA damage response (DDR)-related aberrations predict therapeutic benefit in cisplatin-treated head and neck squamous cell…”
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Progressive changes in chromatin structure and DNA damage response signals in bone marrow and peripheral blood during myelomagenesis by Gkotzamanidou, M, Terpos, E, Bamia, C, Kyrtopoulos, S A, Sfikakis, P P, Dimopoulos, M A, Souliotis, V L

“…The molecular pathways implicated in multiple myeloma (MM) development are rather unknown. We studied epigenetic and DNA damage response (DDR) signals at…”
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DNA adducts, mutant frequencies and mutation spectra in λlacZ transgenic mice treated with N-nitrosodimethylamine by SOULIOTIS, V. L, VAN DELFT, J. H. M, STEENWINKEL, M.-J. S. T, BAAN, R. A, KYRTOPOULOS, S. A

“…Groups of lambda lacZ transgenic mice were treated i.p. with N-nitrosodimethylamine (NDMA) as single doses of 5 mg/kg or 10 mg/kg or as 10 daily doses of 1…”
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A phase II study evaluating the effect of tamoxifen on DNA repair in melanoma patients treated with dacarbazine by Saunders, M P, Salisbury, A J, O'Byrne, K J, Souliotis, V L, Varcoe, S M, Talbot, D C, Kyrtopoulos, S A, Harris, A L

“…The addition of tamoxifen to dacarbazine containing chemotherapy regimens used in the treatment of melanoma, has been shown to increase response rates, but the…”
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Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea by Philip, P A, Souliotis, V L, Harris, A L, Salisbury, A, Tates, A D, Mitchell, K, van Delft, J H, Ganesan, T S, Kyrtopoulos, S A

“…Dacarbazine (DTIC) is a DNA-methylating drug used in the treatment of malignant melanoma. Among the DNA dducts induced by DTIC are N7-methylguanine (N7-meG)…”
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DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance by Kyrtopoulos, S A, Anderson, L M, Chhabra, S K, Souliotis, V L, Pletsa, V, Valavanis, C, Georgiadis, P

“…DNA adducts are covalent complexes formed between genotoxic carcinogens and DNA bases, and constitute a critical early intermediate on the pathway of chemical…”
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Effects of 2-Chlorodeoxyadenosine and Gold Sodium Thiomalate on Human bcl-2 Gene Expression by Sfikakis, P. P., Dimopoulos, M. A., Souliotis, V. L., Charalambopoulos, D., Mavrikakis, M., Panayiotidis, P.

“…Abstract Aberrant expression of apoptosis-related genes, including the "cell death suppressor gene" bcl-2, may play an important pathogenetic role in cancer…”
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Nitrosamines, alcohol, and gastrointestinal tract cancer: recent epidemiology and experimentation by Chhabra, S K, Souliotis, V L, Kyrtopoulos, S A, Anderson, L M

“…Recent epidemiological and experimental data continues to implicate nitrosamines in causation of gastrointestinal cancers. The evidence is strong for pharynx,…”
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Suppression of interleukin-1β and tumour necrosis factor-α biosynthesis by cadmium in in vitro activated human peripheral blood mononuclear cells by THEOCHARIS, S. E, SOULIOTIS, V. L, PANAYIOTIDIS, P. G

“…Cadmium is a highly toxic element responsible for acute and chronic toxicity in man. There is evidence that cadmium induces pathophysiological effects by…”
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Aberrant Expression of the Costimulatory Molecule CD40 Ligand on Monocytes from Patients with Systemic Lupus Erythematosus by Katsiari, Christina G., Liossis, Stamatis-Nick C., Souliotis, Vassilis L., Dimopoulos, Athanasios M., Manoussakis, Menelaos N., Sfikakis, Petros P.

“…CD40 ligand (CD40L, CD154) is overexpressed on T and B cells in systemic lupus erythematosus (SLE). Monocytes have been shown to contribute to immune-mediated…”
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Novel, sensitive assays for O6-alkylguanine and its repair and their application to studies of the molecular epidemiology of this lesion in human populations by Kyrtopoulos, S A, Souliotis, V L, Ambatzi, P, Pangalis, G, Bousiotou, V, Haritopoulos, G, Davaris, G

“…Two assays suitable for monitoring human populations are presented--one for O6-alkylguanine-type adducts and one for the corresponding repair activity. The…”
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Downregulation of Interleukin-2 and α-Chain Interleukin-2 Receptor Biosynthesis by Cisplatin in Human Peripheral Lymphocytes by Sfikakis, P.P., Souliotis, V.L., Katsilambros, N., Markakis, K., Vaiopoulos, G., Tsokos, G.C., Panayiotidis, P.

“…To further investigate the mechanisms by which the antineoplastic agent cisplatin interferes with immune function, we studied its effect on the biosynthesis of…”
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Alcohol-related cancer risk: a toxicokinetic hypothesis by Anderson, L M, Chhabra, S K, Nerurkar, P V, Souliotis, V L, Kyrtopoulos, S A

“…Consumption of alcoholic beverages is an accepted social custom world-wide. This makes its involvement in events contributing to human cancer risk very…”
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O6-Methylguanine DNA adduct formation and modulation by ethanol in placenta and fetal tissues after exposure of pregnant patas monkeys to N-nitrosodimethylamine by CHHABRA, S. K, SOULIOTIS, V. L, HARBAUGH, J. W, KRASNOW, S. W, JONES, A. B, ANDERSON, L. M, KYRTOPOULOS, S. A

“…Perinatal nitrosamine exposures may contribute to childhood cancer risk. To test primate fetal susceptibility to formation of cancer initiation-related DNA…”
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Dosimetry of O6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis by Souliotis, V L, Chhabra, S, Anderson, L M, Kyrtopoulos, S A

“…Groups of female Wistar Furth/NCr rats, aged 6 weeks or 7 months at the start of the experiment, were administered drinking water containing…”
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Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine by Souliotis, Vassilis L., Valavanis, Christos, Boussiotis, Viki A., Pangalis, Gerasimos A., Kyrtopoulos, Soterios A.

“…The mutagenic, carcinogenic and cytotoxic activity of dacarbazine, a drug employed in cancer chemotherapy, may be related to the induction in DNA of…”
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