Search Results - "SOTOMAYOR, Eduardo M"

Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019 by Gracia-Hernandez, Maria, Sotomayor, Eduardo M, Villagra, Alejandro

“…Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a…”
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Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth by Bergman, Joel A, Woan, Karrune, Perez-Villarroel, Patricio, Villagra, Alejandro, Sotomayor, Eduardo M, Kozikowski, Alan P

“…The incidence of malignant melanoma has dramatically increased in recent years thus requiring the need for improved therapeutic strategies. In our efforts to…”
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Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors by Li, Weiping, Gupta, Shiv K, Han, Weiguo, Kundson, Ryan A, Nelson, Sara, Knutson, Darlene, Greipp, Patricia T, Elsawa, Sherine F, Sotomayor, Eduardo M, Gupta, Mamta

“…Double/triple-hit lymphomas (DHL/THL) account for 5-10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in…”
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Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function by Huang, Jianbing, Wang, Liqing, Dahiya, Satinder, Beier, Ulf H., Han, Rongxiang, Samanta, Arabinda, Bergman, Joel, Sotomayor, Eduardo M., Seto, Edward, Kozikowski, Alan P., Hancock, Wayne W.

“…Current interest in Foxp3+ T-regulatory (Treg) cells as therapeutic targets in transplantation is largely focused on their harvesting pre-transplant, expansion…”
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The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance by Villagra, Alejandro, Sotomayor, Eduardo M, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil, Pinilla-Ibarz, Javier, Seto, Edward

“…Interleukin 10 dampens inflammation and prevents excessive tissue damage during immune responses. Sotomayor and colleagues show that the histone deacetylase…”
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BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models by Zhao, Xiaohong, Ren, Yuan, Lawlor, Matthew, Shah, Bijal D., Park, Paul M.C., Lwin, Tint, Wang, Xuefeng, Liu, Kenian, Wang, Michelle, Gao, Jing, Li, Tao, Xu, Mousheng, Silva, Ariosto S., Lee, Kaplan, Zhang, Tinghu, Koomen, John M., Jiang, Huijuan, Sudalagunta, Praneeth R., Meads, Mark B., Cheng, Fengdong, Bi, Chengfeng, Fu, Kai, Fan, Huitao, Dalton, William S., Moscinski, Lynn C., Shain, Kenneth H., Sotomayor, Eduardo M., Wang, Gang Greg, Gray, Nathanael S., Cleveland, John L., Qi, Jun, Tao, Jianguo

“…Drug-tolerant “persister” tumor cells underlie emergence of drug-resistant clones and contribute to relapse and disease progression. Here we report that…”
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EBV‐positive diffuse large B‐cell lymphoma of the elderly: 2016 update on diagnosis, risk‐stratification, and management by Castillo, Jorge J., Beltran, Brady E., Miranda, Roberto N., Young, Ken H., Chavez, Julio C., Sotomayor, Eduardo M.

“…Epstein–Barr virus (EBV)‐positive diffuse large B‐cell lymphoma (DLBCL) of the elderly is a provisional entity included in the 2008 WHO classification of…”
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A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs by Cheng, Fengdong, Lienlaf, Maritza, Wang, Hong-Wei, Perez-Villarroel, Patricio, Lee, Calvin, Woan, Karrune, Rock-Klotz, Jennifer, Sahakian, Eva, Woods, David, Pinilla-Ibarz, Javier, Kalin, Jay, Tao, Jianguo, Hancock, Wayne, Kozikowski, Alan, Seto, Edward, Villagra, Alejandro, Sotomayor, Eduardo M

“…APCs are critical in T cell activation and in the induction of T cell tolerance. Epigenetic modifications of specific genes in the APC play a key role in this…”
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HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms by Yue, Lanzhu, Sharma, Vasundhara, Horvat, Nathan P., Akuffo, Afua A., Beatty, Matthew S., Murdun, Cem, Colin, Christelle, Billington, Julia M.R., Goodheart, William E., Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia N., Pinilla-Ibarz, Javier, Reuther, Gary W., Wright, Kenneth L., Conti, Chiara, Lee, Jennifer Y., Zheng, Xiaozhang, Ng, Pui Yee, Martin, Matthew W., Marshall, C. Gary, Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo M., Shao, Zonghong, Epling-Burnette, Pearlie K.

“…Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6 (HDAC6) controls JAK2 translation and protein stability and has…”
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Epigenetic Regulation of a Brain-specific Glycosyltransferase N-Acetylglucosaminyltransferase-IX (GnT-IX) by Specific Chromatin Modifiers by Kizuka, Yasuhiko, Kitazume, Shinobu, Okahara, Kyohei, Villagra, Alejandro, Sotomayor, Eduardo M., Taniguchi, Naoyuki

“…Expression of glycosyltransferase genes is essential for glycosylation. However, the detailed mechanisms of how glycosyltransferase gene expression is…”
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Vaccination With Patient-Specific Tumor-Derived Antigen in First Remission Improves Disease-Free Survival in Follicular Lymphoma by SCHUSTER, Stephen J, NEELAPU, Sattva S, MCGAUGHEY, Dean S, JAFFE, Elaine S, CHONG, Elise A, REYNOLDS, Craig W, BERRY, Donald A, SANTOS, Carlos F, POPA, Mihaela A, MCCORD, Amy M, KWAK, Larry W, GAUSE, Barry L, JANIK, John E, MUGGIA, Franco M, GOCKERMAN, Jon P, WINTER, Jane N, FLOWERS, Christopher R, NIKCEVICH, Daniel A, SOTOMAYOR, Eduardo M

“…Vaccination with hybridoma-derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with…”
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Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas by Gao, Jing, Wang, Michelle Y, Ren, Yuan, Lwin, Tint, Li, Tao, Yan, Joy C, Sotomayor, Eduardo M, Duckett, Derek R, Shah, Bijal D, Shain, Kenneth H, Zhao, Xiaohong, Tao, Jianguo

“…Despite significant progress in the treatment of patients with diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), the prognosis of patients…”
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Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology by Sahakian, Eva, Chen, Jie, Powers, John J., Chen, Xianghong, Maharaj, Kamira, Deng, Susan L., Achille, Alex N., Lienlaf, Maritza, Wang, Hong Wei, Cheng, Fengdong, Sodré, Andressa L., Distler, Allison, Xing, Limin, Perez‐Villarroel, Patricio, Wei, Sheng, Villagra, Alejandro, Seto, Ed, Sotomayor, Eduardo M., Horna, Pedro, Pinilla‐Ibarz, Javier

“…Expression of HDAC11 may be involved in myeloid cell biology. Epigenetic changes in chromatin structure have been recently associated with the deregulated…”
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The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity by Woods, David M, Woan, Karrune, Cheng, Fengdong, Wang, Hongwei, Perez-Villarroel, Patricio, Lee, Calvin, Lienlaf, Maritza, Atadja, Peter, Seto, Edward, Weber, Jeffrey, Sotomayor, Eduardo M, Villagra, Alejandro

“…Melanoma is the deadliest skin cancer, and its incidence has been increasing faster than any other cancer. Although immunogenic, melanoma is not effectively…”
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The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions by Yuan, Zhigang, Villagra, Alejandro, Peng, Lirong, Coppola, Domenico, Glozak, Michele, Sotomayor, Eduardo M., Chen, Jiandong, Lane, William S., Seto, Edward

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A comprehensive case study on successful multimodal therapy in philadelphia chromosome-positive acute myeloid leukemia with NPM1 and IDH2 mutations by Haider, Syed Muhammad Waqar, Zehra, Mehwish, Shah, Nikesh N, Sotomayor, Eduardo M, Swoboda, David M

“…A 67-year-old female came to Tampa General Hospital with Philadelphia chromosome-positive (Ph+) acute myeloid leukemia (AML) featuring an intriguing…”
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Monoclonal antibodies for B-cell lymphomas: rituximab and beyond by Bello, Celeste, Sotomayor, Eduardo M

“…The year 2007 marks the 10th anniversary of approval by the U.S. Food and Drug Adminstration of the first monoclonal antibody for the treatment of cancer…”
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Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas by Wu, Huanwen, Bui, Marilyn M, Leston, Douglas G, Shao, Haipeng, Sokol, Lubomir, Sotomayor, Eduardo M, Zhang, Ling

“…Malignant bone lymphoma can be classified as primary (PBL) or secondary (SBL) bone lymphoma. However, the clinico-pathological characteristics and prognostic…”
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Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells by Gabrilovich, Dmitry I, Velders, Markwin P, Sotomayor, Eduardo M, Kast, W. Martin

“…The mechanism of tumor-associated T cell dysfunction remains an unresolved problem of tumor immunology. Development of T cell defects in tumor-bearing hosts…”
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Results of a phase II study of lenalidomide and rituximab for refractory/relapsed chronic lymphocytic leukemia by Chavez, Julio C., MD, Piris-Villaespesa, Miguel, MD, Dalia, Samir, MD, Powers, John, PhD, Turba, Elyce, RN, Nodzon, Lisa, ARNP, Komrokji, Rami, MD, Sokol, Lubomir, PhD, Locke, Frederick L., MD, Lancet, Jeffrey, MD, Sotomayor, Eduardo M., MD, Kharfan-Dabaja, Mohamed A., MD, Pinilla-Ibarz, Javier, MD, PhD

“…Highlights • Chronic lymphocytic leukemia (CLL) remains an incurable disease with conventional chemotherapy or chemoimmunotherapy. • Lenalidomide and rituximab…”
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