Search Results - "SOSABOWSKI, Jane"

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells by Emami-Shahri, Nia, Foster, Julie, Kashani, Roxana, Gazinska, Patrycja, Cook, Celia, Sosabowski, Jane, Maher, John, Papa, Sophie

“…The unprecedented efficacy of chimeric antigen receptor (CAR) T-cell immunotherapy of CD19 + B-cell malignancy has established a new therapeutic pillar of…”
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Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo by Kafa, Houmam, Wang, Julie Tzu-Wen, Rubio, Noelia, Klippstein, Rebecca, Costa, Pedro M., Hassan, Hatem A.F.M., Sosabowski, Jane K., Bansal, Sukhvinder S., Preston, Jane E., Abbott, N. Joan, Al-Jamal, Khuloud T.

“…Brain glioblastoma and neurodegenerative diseases are still largely untreated due to the inability of most drugs to cross the blood–brain barrier (BBB)…”
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Cancer associated fibroblast FAK regulates malignant cell metabolism by Demircioglu, Fevzi, Wang, Jun, Candido, Juliana, Costa, Ana S. H., Casado, Pedro, de Luxan Delgado, Beatriz, Reynolds, Louise E., Gomez-Escudero, Jesus, Newport, Emma, Rajeeve, Vinothini, Baker, Ann-Marie, Roy-Luzarraga, Marina, Graham, Trevor A., Foster, Julie, Wang, Yu, Campbell, James J., Singh, Rajinder, Zhang, Penglie, Schall, Thomas J., Balkwill, Frances R., Sosabowski, Jane, Cutillas, Pedro R., Frezza, Christian, Sancho, Patricia, Hodivala-Dilke, Kairbaan

“…Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we…”
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Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach by Faruqu, Farid N, Wang, Julie Tzu-Wen, Xu, Lizhou, McNickle, Luke, Chong, Eden Ming-Yiu, Walters, Adam, Gurney, Mark, Clayton, Aled, Smyth, Lesley A, Hider, Robert, Sosabowski, Jane, Al-Jamal, Khuloud T

“…Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug delivery vectors due to their biological origin and inherent…”
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Anesthesia and Monitoring of Animals During MRI Studies by Tremoleda, Jordi L, Macholl, Sven, Sosabowski, Jane K

“…The use of imaging represents a major impact on the refinement and the reduction of in vivo studies in animal models, in particular for allowing longitudinal…”
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Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo by Suffian, Izzat Fahimuddin Bin Mohamed, Wang, Julie Tzu-Wen, Hodgins, Naomi O, Martin, Rebecca Klippstein, Garcia-Maya, Mitla, Brown, Paul, Nishimura, Yuya, Heidari, Hamed, Bals, Sara, Sosabowski, Jane, Ogino, Chiaki, Kondo, Akihiko, Al-Jamal, Khuloud T

“…Abstract Hepatitis B Virus core (HBc) particles have been studied for their potential as drug delivery vehicles for cancer therapy. HBc particles are hollow…”
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Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects by Paillas, Salomé, Ladjohounlou, Riad, Lozza, Catherine, Pichard, Alexandre, Boudousq, Vincent, Jarlier, Marta, Sevestre, Samuel, Le Blay, Marion, Deshayes, Emmanuel, Sosabowski, Jane, Chardès, Thierry, Navarro-Teulon, Isabelle, Mairs, Robert J, Pouget, Jean-Pierre

“…We investigated whether radiation-induced nontargeted effects are involved in the cytotoxic effects of anticell surface monoclonal antibodies labeled with…”
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Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting by Klingler, Maximilian, Decristoforo, Clemens, Rangger, Christine, Summer, Dominik, Foster, Julie, Sosabowski, Jane K, von Guggenberg, Elisabeth

“…Minigastrin (MG) analogs show high affinity to the cholecystokinin-2 receptor (CCK2R) and have therefore been intensively studied to find a suitable analog for…”
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Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents by Wang, Julie Tzu-Wen, Cabana, Laura, Bourgognon, Maxime, Kafa, Houmam, Protti, Andrea, Venner, Kerrie, Shah, Ajay M., Sosabowski, Jane K., Mather, Stephen J., Roig, Anna, Ke, Xiaoxing, Van Tendeloo, Gustaaf, de Rosales, Rafael T. M., Tobias, Gerard, Al-Jamal, Khuloud T.

“…Carbon nanotubes (CNTs) are one of the most promising nanomaterials to be used in biomedicine for drug/gene delivery as well as biomedical imaging. This study…”
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Selection of radionuclide(s) for targeted alpha therapy based on their nuclear decay properties by Ree, Samantha M, Greenwood, Howard, Young, Jennifer D, Roberts, Rachel F C, Livens, Francis R, Heath, Scott L, Sosabowski, Jane K

“…Targeted alpha therapy (TAT) is a promising form of oncology treatment utilising alpha-emitting radionuclides that can specifically accumulate at disease…”
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Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity? by van der Stegen, Sjoukje J C, Davies, David M, Wilkie, Scott, Foster, Julie, Sosabowski, Jane K, Burnet, Jerome, Whilding, Lynsey M, Petrovic, Roseanna M, Ghaem-Maghami, Sadaf, Mather, Stephen, Jeannon, Jean-Pierre, Parente-Pereira, Ana C, Maher, John

“…The ErbB network is dysregulated in many solid tumors. To exploit this, we have developed a chimeric Ag receptor (CAR) named T1E28z that targets several…”
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The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo by Wang, Julie T-W, Fabbro, Chiara, Venturelli, Enrica, Ménard-Moyon, Cécilia, Chaloin, Olivier, Da Ros, Tatiana, Methven, Laura, Nunes, Antonio, Sosabowski, Jane K, Mather, Stephen J, Robinson, Martyn K, Amadou, Julien, Prato, Maurizio, Bianco, Alberto, Kostarelos, Kostas, Al-Jamal, Khuloud T

“…Abstract Carbon nanotubes (CNTs) exhibit unique properties which have led to their applications in the biomedical field as novel delivery systems for diagnosis…”
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New Bioconjugated Technetium and Rhenium Folates Synthesized by Transmetallation Reaction with Zinc Derivatives by Borràs, Jordi, Foster, Julie, Kashani, Roxana, Meléndez-Alafort, Laura, Sosabowski, Jane, Suades, Joan, Barnadas-Rodríguez, Ramon

“…The zinc dithiocarbamates functionalized with folic acid and were synthesized with a simple straightforward method, using an appropriated folic acid derivative…”
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Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging by ALLEN, Michael D, PHUONG LUONG, LATTANZIO, Laura, CHMIELEWSKA-KASSASSIR, Malgorzata, TOMLINSON, Ian, ROYLANCE, Rebecca, WHITAKER, Hayley C, WARREN, Anne Y, NEAL, David, FREZZA, Christian, BELTRAN, Luis, JONES, Louise J, HUDSON, Chantelle, CHELALA, Claude, WU, Bor-Wen, BOMALASKI, John S, JACKSON, Robert C, LU, Yong-Jie, CROOK, Tim, LEMOINE, Nicholas R, MATHER, Stephen, FOSTER, Julie, SOSABOWSKI, Jane, LEYTON, Julius, AVRIL, Norbert, LI, Chien-Feng, SZLOSAREK, Peter W, DELAGE, Barbara, GHAZALY, Essam, CUTTS, Rosalind, MING YUAN, SYED, Nelofer, LO NIGRO, Cristiana

“…Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme…”
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Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses by Wang, Julie T.-W., Rubio, Noelia, Kafa, Houmam, Venturelli, Enrica, Fabbro, Chiara, Ménard-Moyon, Cécilia, Da Ros, Tatiana, Sosabowski, Jane K., Lawson, Alastair D., Robinson, Martyn K., Prato, Maurizio, Bianco, Alberto, Festy, Frederic, Preston, Jane E., Kostarelos, Kostas, Al-Jamal, Khuloud T.

“…Earlier studies proved the success of using chemically functionalised multi-walled carbon nanotubes (f-MWNTs) as nanocarriers to the brain. Little insight into…”
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Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy by Hodgins, Naomi O., Al-Jamal, Wafa' T., Wang, Julie T.-W., Klippstein, Rebecca, Costa, Pedro M., Sosabowski, Jane K., Marshall, John F., Maher, John, Al-Jamal, Khuloud T.

“…The αvβ6 integrin receptor has been shown to be overexpressed on many types of cancer cells, resulting in a more pro-invasive and aggressive phenotype, this…”
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Radiolabelled peptides for oncological diagnosis by Laverman, Peter, Sosabowski, Jane K., Boerman, Otto C., Oyen, Wim J. G.

“…Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy…”
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Adoptive Immunotherapy of Epithelial Ovarian Cancer with V gamma 9V delta 2 T Cells, Potentiated by Liposomal Alendronic Acid by Parente-Pereira, Ana C, Shmeeda, Hilary, Whilding, Lynsey M, Zambirinis, Constantinos P, Foster, Julie, van der Stegen, Sjoukje JC, Beatson, Richard, Zabinski, Tomasz, Brewig, Nancy, Sosabowski, Jane K, Mather, Stephen, Ghaem-Maghami, Sadaf, Gabizon, Alberto, Maher, John

“…Adoptive immunotherapy using gamma delta T cells harnesses their natural role in tumor immunosurveillance. The efficacy of this approach is enhanced by…”
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Adoptive immunotherapy of epithelial ovarian cancer with Vγ9Vδ2 T cells, potentiated by liposomal alendronic acid by Parente-Pereira, Ana C, Shmeeda, Hilary, Whilding, Lynsey M, Zambirinis, Constantinos P, Foster, Julie, van der Stegen, Sjoukje J C, Beatson, Richard, Zabinski, Tomasz, Brewig, Nancy, Sosabowski, Jane K, Mather, Stephen, Ghaem-Maghami, Sadaf, Gabizon, Alberto, Maher, John

“…Adoptive immunotherapy using γδ T cells harnesses their natural role in tumor immunosurveillance. The efficacy of this approach is enhanced by…”
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18F‑Trifluoromethanesulfinate Enables Direct C–H 18F‑Trifluoromethylation of Native Aromatic Residues in Peptides by Kee, Choon Wee, Tack, Osman, Guibbal, Florian, Wilson, Thomas C, Isenegger, Patrick G, Imiołek, Mateusz, Verhoog, Stefan, Tilby, Michael, Boscutti, Giulia, Ashworth, Sharon, Chupin, Juliette, Kashani, Roxana, Poh, Adeline W. J, Sosabowski, Jane K, Macholl, Sven, Plisson, Christophe, Cornelissen, Bart, Willis, Michael C, Passchier, Jan, Davis, Benjamin G, Gouverneur, Véronique

“…18F labeling strategies for unmodified peptides with [18F]­fluoride require 18F-labeled prosthetics for bioconjugation more often with cysteine thiols or…”
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