Search Results - "SOOS, M. A"

Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors by Semple, R. K., Soos, M. A., Luan, J., Mitchell, C. S., Wilson, J. C., Gurnell, M., Cochran, E. K., Gorden, P., Chatterjee, V. K. K., Wareham, N. J., O’Rahilly, S.

“…Context: Adiponectin has been suggested to play a role in the etiopathogenesis of at least some forms of insulin resistance, in part based on a strong…”
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Severe insulin resistance due to anti‐insulin antibodies: response to plasma exchange and immunosuppressive therapy by Greenfield, J. R., Tuthill, A., Soos, M. A., Semple, R. K., Halsall, D. J., Chaudhry, A., O’Rahilly, S.

“…Anti‐insulin antibodies have been described in two contexts: in insulin‐naive individuals (so‐called ‘insulin autoimmune syndrome’) and in patients with…”
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Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension by O'Rahilly, S, Barroso, I, Gurnell, M, Crowley, V. E. F, Agostini, M, Schwabe, J. W, Soos, M. A, Maslen, G. LI, Williams, T. D. M, Lewis, H, Schafer, A. J, Chatterjee, V. K. K

“…Thiazolidinediones are a new class of antidiabetic agent that improve insulin sensitivity and reduce plasma glucose and blood pressure in subjects with type 2…”
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Congenital leptin deficiency is associated with severe early-onset obesity in humans by O'Rahilly, Stephen, Montague, Carl T, Farooqi, I. Sadaf, Whitehead, Jonathan P, Soos, Maria A, Rau, Harald, Wareham, Nicholas J, Sewter, Ciaran P, Digby, Janet E, Mohammed, Shehla N, Hurst, Jane A, Cheetham#, Christopher H, Earley#, Alison R, Barnett, Anthony H, Prins, Johannes B

“…The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has…”
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Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling by Raffan, E., Soos, M. A., Rocha, N., Tuthill, A., Thomsen, A. R., Hyden, C. S., Gregory, J. W., Hindmarsh, P., Dattani, M., Cochran, E., Al Kaabi, J., Gorden, P., Barroso, I., Morling, N., O’Rahilly, S., Semple, R. K.

“…Aims/hypothesis Genetic insulin receptoropathies are a rare cause of severe insulin resistance. We identified the Ile119Met missense mutation in the insulin…”
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Functional characterization of a novel insulin receptor mutation contributing to Rabson-Mendenhall syndrome by Tuthill, A., Semple, R. K., Day, R., Soos, M. A., Sweeney, E., Seymour, P. J., Didi, M., O'Rahilly, S.

“…Summary Objective/Patients  Rabson–Mendenhall syndrome (RMS) is a rare, recessively inherited disorder of extreme insulin resistance due to mutations in the…”
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Defect in Insulin-Like Growth Factor-1 Survival Mechanism in Atherosclerotic Plaque-Derived Vascular Smooth Muscle Cells Is Mediated by Reduced Surface Binding and Signaling by Patel, V A, Zhang, Q.-J, Siddle, K, Soos, M A, Goddard, M, Weissberg, P L, Bennett, M R

“…ABSTRACT—Apoptosis of vascular smooth muscle cells (VSMCs) is increased in atherosclerosis compared with normal vessels, where it may contribute to plaque…”
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Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors by Siddle, K, Ursø, B, Niesler, C A, Cope, D L, Molina, L, Surinya, K H, Soos, M A

“…The physiological roles of insulin and insulin-like growth factors (IGFs) are distinct, with insulin acting to regulate cellular uptake and metabolism of…”
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Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity by SOOS, M. A, FIELD, C. E, SIDDLE, K

“…Hybrid insulin/insulin-like growth factor-I (IGF-I) receptors have previously been described in human placenta, but it has not been possible to study their…”
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IRS2 variants and syndromes of severe insulin resistance by Bottomley, W. E, Soos, M. A, Adams, C, Guran, T, Howlett, T. A, Mackie, A, Miell, J, Monson, J. P, Temple, R, Tenenbaum-Rakover, Y, Tymms, J, Savage, D. B, Semple, R. K, O'Rahilly, S, Barroso, I

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Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies by Malek, R., Chong, A. Y., Lupsa, B. C., Lungu, A. O., Cochran, E. K., Soos, M. A., Semple, R. K., Balow, J. E., Gorden, P.

“…Background: Type B insulin resistance belongs to a class of diseases caused by an autoantibody to a cell surface receptor. Blockade of insulin action results…”
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Successful treatment of Type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus by Coll, A. P., Morganstein, D., Jayne, D., Soos, M. A., O'Rahilly, S., Burke, J.

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Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene by Savage, D B, Soos, M A, Powlson, A, O'Rahilly, S, McFarlane, I, Halsall, D J, Barroso, I, Thomas, E L, Bell, J D, Scobie, I, Belchetz, P E, Kelly, W F, Schafer, A J

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Deletion of V335 from the L2 Domain of the Insulin Receptor Results in a Conformationally Abnormal Receptor That Is Unable to Bind Insulin and Causes Donohue’s Syndrome in a Human Subject by George, S, Johansen, A, Soos, M. A, Mortensen, H, Gammeltoft, S, Saudek, V, Siddle, K, Hansen, L, O’Rahilly, S

“…An infant with Donohue’s syndrome (leprechaunism) was found to be homozygous for an in-frame trinucleotide deletion within the insulin receptor gene resulting…”
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Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants by SCHUMACHER, R, SOOS, M. A, SCHLESSINGER, J, BRANDENBURG, D, SIDDLE, K, ULLRICH, A

“…Chimeric receptors were generated in which structurally defined subdomains of the insulin receptor (IR) and insulin growth factor-I receptor (IGF-1R)…”
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Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors by Soos, M A, Siddle, K

“…The receptors for insulin and insulin-like growth factor-I (IGF-I) are closely related in primary sequence and overall structure. We have examined the…”
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Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells by Soos, M A, Whittaker, J, Lammers, R, Ullrich, A, Siddle, K

“…We have demonstrated the formation of hybrid insulin/insulin-like growth factor-I(IGF-I) receptors in transfected rodent fibroblasts, which overexpress human…”
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Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors by OGILVY-STUART, A. L, SOOS, M. A, HANDS, S. J, ANTHONY, M. Y, DUNGER, D. B, O'RAHILLY, S

“…Humans with congenital absence of the islets of Langerhans and mice rendered null for the insulin receptor rapidly develop severe hyperglycemia and…”
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A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity by SOOS, M. A, FIELD, C. E, LAMMERS, R, ULLRICH, A, BEI ZHANG, ROTH, R. A, ANDERSEN, A. S, KJELDSEN, T, SIDDLE, K

“…We obtained 20 mouse monoclonal antibodies specific for human type I insulin-like growth factor (IGF) receptors, using transfected cells expressing high levels…”
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Transdominant Inhibition of Tyrosine Kinase Activity in Mutant Insulin/ Insulin-Like Growth Factor I Hybrid Receptors by Treadway, Judith L., Morrison, Brian D., Soos, Maria A., Siddle, Kenneth, Olefsky, Jerrold, Ullrich, Axel, McClain, Donald A., Pessin, Jeffrey E.

“…Classical insulin and insulin-like growth factor I (IGF-I) receptors exist as well defined α2β2heterotetrameric complexes that are assembled from two identical…”
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