Search Results - "SONSALLA, P. K"

Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson's disease by Zeevalk, G.D., Manzino, L., Sonsalla, P.K., Bernard, L.P.

“…Parkinson's disease (PD) is associated with loss of total glutathione (GSH) which may contribute to progressive cell death. Peripheral GSH administration has…”
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Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease by Chen, J F, Xu, K, Petzer, J P, Staal, R, Xu, Y H, Beilstein, M, Sonsalla, P K, Castagnoli, K, Castagnoli, Jr, N, Schwarzschild, M A

“…Recent epidemiological studies have established an association between the common consumption of coffee or other caffeinated beverages and a reduced risk of…”
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Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP +) by Yazdani, U., German, D.C., Liang, C.-L., Manzino, L., Sonsalla, P.K., Zeevalk, G.D

“…Mitochondrial dysfunction is observed in sporadic Parkinson's disease (PD) and may contribute to progressive neurodegeneration. While acute models of…”
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Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents by Albers, D S, Sonsalla, P K

“…Neurotoxic doses of methamphetamine (METH) can cause hyperthermia in experimental animals. Damage sustained to dopaminergic nerve terminals by this stimulant…”
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Role for Dopamine in Malonate‐Induced Damage In Vivo in Striatum and In Vitro in Mesencephalic Cultures by Moy, L. Y., Zeevalk, G. D., Sonsalla, P. K.

“…: Defects in mitochondrial energy metabolism have been implicated in the pathology of several neurodegenerative disorders. In addition, the reactive…”
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Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism by Sonsalla, P K, Albers, D S, Zeevalk, G D

“…Although controversial, studies with methamphetamine and MPTP suggest a link between glutamate-mediated excitotoxicity and degeneration of dopamine cells. Both…”
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Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice by Sonsalla, P K, Riordan, D E, Heikkila, R E

“…The administration of methamphetamine (METH) to experimental animals results in damage to nigrostriatal dopaminergic neurons. We have demonstrated previously…”
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Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons by German, D.C, Liang, C.-L, Manaye, K.F, Lane, K, Sonsalla, P.K

“…The vesicular monoamine transporter in the brain can sequester the neurotoxin 1-methyl-4-phenylpyridinium into synaptic vesicles and protect…”
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Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration by Giovanni, A, Sieber, B A, Heikkila, R E, Sonsalla, P K

“…Several parameters necessary for the expression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity to dopaminergic neurons were…”
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The neurotoxin 1-methyl-4-phenylpyridinium is sequestered within neurons that contain the vesicular monoamine transporter by Speciale, S.G., Liang, C.-L., Sonsalla, P.K., Edwards, R.H., German, D.C.

“…The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces a parkinsonian syndrome in man and experimental animals. The toxic metabolite of…”
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Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium by Giovanni, A, Sonsalla, P K, Heikkila, R E

“…There are marked species differences in susceptibility to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice are sensitive,…”
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Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice by Giovanni, A, Sieber, B A, Heikkila, R E, Sonsalla, P K

“…In the present study we observed pronounced differences in the capacity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce dopaminergic…”
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Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity by Sonsalla, Patricia K., Nicklas, William J., Heikkila, Richard E.

“…The systemic administration of either methamphetamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to experimental animals produces degenerative…”
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Protection against methamphetamine-induced neurotoxicity to neostriatal dopaminergic neurons by adenosine receptor activation by Delle Donne, K T, Sonsalla, P K

“…Methamphetamine (METH)-induced neurotoxicity to nigrostriatal dopaminergic neurons in experimental animals appears to have a glutamatergic component because…”
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Role of dopamine in the neurotoxic effects of methamphetamine by Schmidt, C J, Ritter, J K, Sonsalla, P K, Hanson, G R, Gibb, J W

“…Multiple administrations of high doses of methamphetamine to rats cause long-term depression of both dopamine and serotonin synthesis. Coadministration of the…”
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Long-term duodenal infusion of levodopa for motor fluctuations in parkinsonism by Sage, J I, Trooskin, S, Sonsalla, P K, Heikkila, R, Duvoisin, R C

“…We report the long-term clinical responses of 2 parkinsonian patients with severe "on-off" phenomena who have been receiving continuous duodenal levodopa (LD)…”
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MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats by Sonsalla, P K, Zeevalk, G D, Manzino, L, Giovanni, A, Nicklas, W J

“…Previous studies from this laboratory demonstrated that (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801), an…”
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The sigma receptor ligand (+/-)-BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors by Terleckyj, I, Sonsalla, P K

“…The possibility that compounds which interact with the putative sigma receptor might influence the dopaminergic neuropathology produced by the administration…”
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Roles of D1 and D2 dopamine receptor subtypes in mediating the methamphetamine-induced changes in monoamine systems by Sonsalla, P K, Gibb, J W, Hanson, G R

“…Previous studies have demonstrated that the effects of methamphetamine (METH) on dopaminergic and serotonergic systems are likely related to METH-induced…”
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Energy Stress‐Induced Dopamine Loss in Glutathione Peroxidase‐Overexpressing Transgenic Mice and in Glutathione‐Depleted Mesencephalic Cultures by Zeevalk, Gail D., Bernard, Laura P., Albers, David S., Mirochnitchenko, Oleg, Nicklas, William J., Sonsalla, Patricia K.

“…: The role of the glutathione system in protecting dopamine neurons from a mild impairment of energy metabolism imposed by the competitive succinate…”
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