Search Results - "SONABEND, Adam M"

Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment by Arrieta, Víctor A, Dmello, Crismita, McGrail, Daniel J, Brat, Daniel J, Lee-Chang, Catalina, Heimberger, Amy B, Chand, Dhan, Stupp, Roger, Sonabend, Adam M

“…Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro-oncology community. While several reports show…”
Get full text

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma by Zhao, Junfei, Chen, Andrew X., Gartrell, Robyn D., Silverman, Andrew M., Aparicio, Luis, Chu, Tim, Bordbar, Darius, Shan, David, Samanamud, Jorge, Mahajan, Aayushi, Filip, Ioan, Orenbuch, Rose, Goetz, Morgan, Yamaguchi, Jonathan T., Cloney, Michael, Horbinski, Craig, Lukas, Rimas V., Raizer, Jeffrey, Rae, Ali I., Yuan, Jinzhou, Canoll, Peter, Bruce, Jeffrey N., Saenger, Yvonne M., Sims, Peter, Iwamoto, Fabio M., Sonabend, Adam M., Rabadan, Raul

“…Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in glioblastomas…”
Get full text

STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma by Zhang, Peng, Rashidi, Aida, Zhao, Junfei, Silvers, Caylee, Wang, Hanxiang, Castro, Brandyn, Ellingwood, Abby, Han, Yu, Lopez-Rosas, Aurora, Zannikou, Markella, Dmello, Crismita, Levine, Rebecca, Xiao, Ting, Cordero, Alex, Sonabend, Adam M., Balyasnikova, Irina V., Lee-Chang, Catalina, Miska, Jason, Lesniak, Maciej S.

“…As a key component of the standard of care for glioblastoma, radiotherapy induces several immune resistance mechanisms, such as upregulation of CD47 and PD-L1…”
Get full text

Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations by Zhang, Daniel Y, Dmello, Crismita, Chen, Li, Arrieta, Victor A, Gonzalez-Buendia, Edgar, Kane, J Robert, Magnusson, Lisa P, Baran, Aneta, James, C David, Horbinski, Craig, Carpentier, Alexandre, Desseaux, Carole, Canney, Michael, Muzzio, Miguel, Stupp, Roger, Sonabend, Adam M

“…Paclitaxel shows little benefit in the treatment of glioma due to poor penetration across the blood-brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU)…”
Get full text

Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm by Ding, Hongxu, Douglass, Eugene F., Sonabend, Adam M., Mela, Angeliki, Bose, Sayantan, Gonzalez, Christian, Canoll, Peter D., Sims, Peter A., Alvarez, Mariano J., Califano, Andrea

“…We and others have shown that transition and maintenance of biological states is controlled by master regulator proteins, which can be inferred by…”
Get full text

Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome by Cloney, Michael, BA, D'Amico, Randy, MD, Lebovic, Jordan, BA, Nazarian, Matthew, BS, Zacharia, Brad E., MD, MS, Sisti, Michael B., MD, Bruce, Jeffrey N., MD, McKhann, Guy M., MD, Iwamoto, Fabio M., MD, Sonabend, Adam M., MD

“…Introduction Frailty is an emerging means of assessing overall health status and guiding management for geriatric patients. Frailty is associated with outcomes…”
Get full text

Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype by Lei, Liang, Sonabend, Adam M, Guarnieri, Paolo, Soderquist, Craig, Ludwig, Thomas, Rosenfeld, Steven, Bruce, Jeffrey N, Canoll, Peter

“…Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into…”
Get full text

Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial by Carpentier, Alexandre, Stupp, Roger, Sonabend, Adam M., Dufour, Henry, Chinot, Olivier, Mathon, Bertrand, Ducray, François, Guyotat, Jacques, Baize, Nathalie, Menei, Philippe, de Groot, John, Weinberg, Jeffrey S., Liu, Benjamin P., Guemas, Eric, Desseaux, Carole, Schmitt, Charlotte, Bouchoux, Guillaume, Canney, Michael, Idbaih, Ahmed

“…Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable…”
Get full text

Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy by Ulasov, Ilya V, Nandi, Suvobroto, Dey, Mahua, Sonabend, Adam M, Lesniak, Maciej S

“…Malignant gliomas are currently treated with temozolomide (TMZ), but often exhibit resistance to this agent. CD133(+) cancer stem cells, a population believed…”
Get full text

Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas by Baldock, Anne L, Ahn, Sunyoung, Rockne, Russell, Johnston, Sandra, Neal, Maxwell, Corwin, David, Clark-Swanson, Kamala, Sterin, Greg, Trister, Andrew D, Malone, Hani, Ebiana, Victoria, Sonabend, Adam M, Mrugala, Maciej, Rockhill, Jason K, Silbergeld, Daniel L, Lai, Albert, Cloughesy, Timothy, McKhann, 2nd, Guy M, Bruce, Jeffrey N, Rostomily, Robert C, Canoll, Peter, Swanson, Kristin R

“…Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging…”
Get full text

Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma by Chastkofsky, Michael I, Pituch, Katarzyna C, Katagi, Hiroaki, Zannikou, Markella, Ilut, Liliana, Xiao, Ting, Han, Yu, Sonabend, Adam M, Curiel, David T, Bonner, Erin R, Nazarian, Javad, Horbinski, Craig M, James, C David, Saratsis, Amanda M, Hashizume, Rintaro, Lesniak, Maciej S, Balyasnikova, Irina V

“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
Get full text

Craniotomy and Survival for Primary Central Nervous System Lymphoma by Rae, Ali I, Mehta, Amol, Cloney, Michael, Kinslow, Connor J, Wang, Tony J C, Bhagat, Govind, Canoll, Peter D, Zanazzi, George J, Sisti, Michael B, Sheth, Sameer A, Connolly, E Sander, McKhann, Guy M, Bruce, Jeffrey N, Iwamoto, Fabio M, Sonabend, Adam M

“…Abstract BACKGROUND Cytoreductive surgery is considered controversial for primary central nervous system lymphoma (PCNSL). OBJECTIVE To investigate survival…”
Get full text

The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia by Arrieta, Víctor A, Najem, Hinda, Petrosyan, Edgar, Lee-Chang, Catalina, Chen, Peiwen, Sonabend, Adam M, Heimberger, Amy B

“…Glioblastomas (GBMs) are complex ecosystems composed of highly multifaceted tumor and myeloid cells capable of responding to different environmental pressures,…”
Get full text

Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade by Dmello, Crismita, Zhao, Junfei, Chen, Li, Gould, Andrew, Castro, Brandyn, Arrieta, Victor A., Zhang, Daniel Y., Kim, Kwang-Soo, Kanojia, Deepak, Zhang, Peng, Miska, Jason, Yeeravalli, Ragini, Habashy, Karl, Saganty, Ruth, Kang, Seong Jae, Fares, Jawad, Liu, Connor, Dunn, Gavin, Bartom, Elizabeth, Schipma, Matthew J., Hsu, Patrick D., Alghamri, Mahmoud S., Lesniak, Maciej S., Heimberger, Amy B., Rabadan, Raul, Lee-Chang, Catalina, Sonabend, Adam M.

“…Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that…”
Get full text

Mesenchymal Stem Cells Effectively Deliver an Oncolytic Adenovirus to Intracranial Glioma by Sonabend, Adam M., Ulasov, Ilya V., Tyler, Matthew A., Rivera, Angel A., Mathis, James M., Lesniak, Maciej S.

“…Gene therapy represents a promising treatment alternative for patients with malignant gliomas. Nevertheless, in the setting of these highly infiltrative…”
Get full text

IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM by Zannikou, Markella, Duffy, Joseph T, Levine, Rebecca N, Seblani, Maggie, Liu, Qianli, Presser, Aaron, Arrieta, Victor A, Chen, Christopher J, Sonabend, Adam M, Horbinski, Craig M, Lee-Chang, Catalina, Miska, Jason, Lesniak, Maciej S, Gottschalk, Stephen, Balyasnikova, Irina V

“…IntroductionThe immunosuppressive tumor microenvironment (TME) is a major barrier to the efficacy of chimeric antigen receptor T cells (CAR-T cells) in…”
Get full text

Next Steps for Immunotherapy in Glioblastoma by Cao, Toni Q, Wainwright, Derek A, Lee-Chang, Catalina, Miska, Jason, Sonabend, Adam M, Heimberger, Amy B, Lukas, Rimas V

“…Outcomes for glioblastoma (GBM) patients undergoing standard of care treatment remain poor. Here we discuss the portfolio of previously investigated…”
Get full text

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era by Larkin, Collin J., Arrieta, Víctor A., Najem, Hinda, Li, Gongbo, Zhang, Peng, Miska, Jason, Chen, Peiwen, James, Charles David, Sonabend, Adam M., Heimberger, Amy B.

“…The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved…”
Get full text

The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis by Sonabend, Adam M, Zacharia, Brad E, Goldstein, Hannah, Bruce, Samuel S, Hershman, Dawn, Neugut, Alfred I, Bruce, Jeffrey N

“…Central nervous system (CNS) hemangiopericytomas are relatively uncommon and unique among CNS tumors as they can originate from or develop metastases outside…”
Get full text

Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy by Mehta, Amol, Awah, Chidiebere U, Sonabend, Adam M

“…Despite advances in surgery, radiotherapy, and chemotherapy, glioblastoma (GBM) remains a malignancy with poor prognosis. The molecular profile of GBM is…”
Get full text