Search Results - "SOMLYO, Andrew P"

Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II by Somlyo, Andrew P., Somlyo, Avril V.

“…We here review mechanisms that can regulate the activity of myosin II, in smooth muscle and non-muscle cells, by modulating the Ca 2+ sensitivity of myosin…”
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Signal transduction and regulation in smooth muscle by Somlyo, Andrew P, Somlyo, Avril V

“…Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their abnormalities contribute to a range of diseases. Although based…”
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RhoA-mediated Ca2+ Sensitization in Erectile Function by Wang, Hua, Eto, Masumi, Steers, William D, Somlyo, Andrew P, Somlyo, Avril V

“…A Rho-kinase inhibitor increases corpus cavernosum (CC) pressure in an in vivo rat model (Chitaley, K., Wingard, C. J., Webb, R. C., Branam, H., Stopper, V…”
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Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase by SOMLYO, ANDREW P, SOMLYO, AVRIL V

“…Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia Somlyo, Andrew P., and Avril V. Somlyo. Ca 2+…”
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Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell Migration by Jo, Minji, Thomas, Keena S., Somlyo, Avril V., Somlyo, Andrew P., Gonias, Steven L.

“…Binding of the urokinase-type plasminogen activator (uPA) to its receptor activates diverse cell signaling pathways. How these signals are integrated so that…”
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Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants by Somlyo, Avril V., Phelps, Clayton, Dipierro, Charles, Eto, Masumi, Read, Paul, Barrett, Matthew, Gibson, Jennifer J., Burnitz, M. Christine, Myers, Charles, Somlyo, Andrew P.

“…The purpose of this study was to determine the effects of inhibitors of Rho kinase (ROK) and matrix metalloproteinases (MMPs) on angiogenesis and tumor growth…”
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Cryo-atomic Force Microscopy of Unphosphorylated and Thiophosphorylated Single Smooth Muscle Myosin Molecules by Sheng, Sitong, Gao, Yan, Khromov, Alexander S., Somlyo, Avril V., Somlyo, Andrew P., Shao, Zhifeng

“…The purpose of this study was to determine whether steric blockage of one head by the second head of native two-headed myosin was responsible for the…”
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LPP, a LIM protein highly expressed in smooth muscle by Gorenne, Isabelle, Nakamoto, Robert K, Phelps, Clayton P, Beckerle, Mary C, Somlyo, Avril V, Somlyo, Andrew P

“…An 80-kDa protein, prominently expressed in smooth muscle, was microsequenced and identified as LPP, the product of the lipoma-preferred partner gene (Petit…”
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Localization of Ryanodine Receptors in Smooth Muscle by Lesh, Ryan E, Nixon, Graeme F, Fleischer, Sidney, Airey, Judith A, Somlyo, Andrew P, Somlyo, Avril V

“…The ryanodine receptor (RyR) in aortic and vas deferens smooth muscle was localized using immunofluorescence confocal microscopy and immunoelectron microscopy…”
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Smooth Muscle Differentiation Marker Gene Expression Is Regulated by RhoA-mediated Actin Polymerization by Mack, Christopher P., Somlyo, Avril V., Hautmann, Martina, Somlyo, Andrew P., Owens, Gary K.

“…Smooth muscle cell (SMC) differentiation is regulated by a complex array of local environmental cues, but the intracellular signaling pathways and the…”
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Modulation of Ca2+ Sensitivity by Cyclic Nucleotides in Smooth Muscle from Protein Kinase G-deficient Mice by Bonnevier, Johan, Fässler, Reinhard, Somlyo, Andrew P., Somlyo, Avril V., Arner, Anders

“…The cGMP-dependent protein kinase (PKG) is the main mediator of nitric oxide-induced relaxation of smooth muscle. Although this pathway is well established,…”
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The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle by Derewenda, Urszula, Oleksy, Arkadiusz, Stevenson, Andra S, Korczynska, Justyna, Dauter, Zbigniew, Somlyo, Andrew P, Otlewski, Jacek, Somlyo, Avril V, Derewenda, Zygmunt S

“…Calcium sensitization in smooth muscle is mediated by the RhoA GTPase, activated by hitherto unspecified nucleotide exchange factors (GEFs) acting downstream…”
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Rho-Kinase Inhibitor Retards Migration and in Vivo Dissemination of Human Prostate Cancer Cells by Somlyo, Avril V., Bradshaw, Dawn, Ramos, Susan, Murphy, Cheryl, Myers, Charles E., Somlyo, Andrew P.

“…The Rho-kinase inhibitor, Y-27632, inhibited in vitro chemotactic migration to bone marrow fibroblast conditioned media and metastatic growth in…”
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Crystal structure of RhoA-GDP and its functional implications by Wei, Yunyi, Zhang, Yan, Derewenda, Urszula, Liu, Xiaopu, Minor, Wladek, Nakamoto, Robert K, Somlyo, Avril V, Somlyo, Andrew P, Derewenda, Zygmunt S

“…RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 A resolution crystal structure of the human RhoA-GDP…”
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Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 Å resolution by Longenecker, Kenton, Read, Paul, Lin, Shin-Kai, Somlyo, Andrew P., Nakamoto, Robert K., Derewenda, Zygmunt S.

“…Mutants of the small G protein RhoA that are deficient in GTPase activity and thereby exhibit constitutive molecular signaling activity are commonly used to…”
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Automated electron tomography with scanning transmission electron microscopy by FENG, JIANGLIN, SOMLYO, ANDREW P, SOMLYO, AVRIL V, SHAO, ZHIFENG

“…We report the successful implementation of a fully automated tomographic data collection system in scanning transmission electron microscopy (STEM) mode…”
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Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle by Gong, M C, Fujihara, H, Somlyo, A V, Somlyo, A P

“…We determined the relationship between the localization of rhoA and Ca 2+ sensitization of force in smooth muscle. In α-toxin-permeabilized rabbit portal vein…”
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Signal transduction through the RhoA/Rho-kinase pathway in smooth muscle by Somlyo, Andrew P, Somlyo, Avril V

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Uncoupling of GPCR and RhoA-induced Ca-sensitization of chicken amnion smooth muscle lacking CPI-17 by Stevenson, Andra S, Matthew, John D, Eto, Masumi, Luo, Shizhen, Somlyo, Andrew P, Somlyo, Avril V

“…Ca2+-sensitization of smooth muscle occurs through inhibition of myosin light chain phosphatase (MLCP) leading to an increase in the MLCK:MLCP activity ratio…”
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Smooth muscle myosin: regulation and properties by Holmes, K. C., Trentham, D. R., Simmons, R., Somlyo, Avril V., Khromov, Alexander S., Webb, Martin R., Ferenczi, Michael A., Trentham, David R., He, Zhen-He, Sheng, Sitong, Shao, Zhifeng, Somlyo, Andrew P.

“…The relationship of the biochemical states to the mechanical events in contraction of smooth muscle cross–bridges is reviewed. These studies use direct…”
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