Search Results - "SOBEY, C. G"

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in mice by Krishnan, S M, Dowling, J K, Ling, Y H, Diep, H, Chan, C T, Ferens, D, Kett, M M, Pinar, A, Samuel, C S, Vinh, A, Arumugam, T V, Hewitson, T D, Kemp‐Harper, B K, Robertson, A A B, Cooper, M A, Latz, E, Mansell, A, Sobey, C G, Drummond, G R

“…Background and Purpose Inflammasomes are multimeric complexes that facilitate caspase‐1‐mediated processing of the pro‐inflammatory cytokines IL‐1β and IL‐18…”
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Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2‐deficient mice by Jackman, KA, Miller, AA, De Silva, TM, Crack, PJ, Drummond, GR, Sobey, CG

“…Background and purpose:  Reactive oxygen species (ROS) derived from Nox2‐containing reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase…”
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IL‐1β and IL‐18: inflammatory markers or mediators of hypertension? by Krishnan, S M, Sobey, C G, Latz, E, Mansell, A, Drummond, G R

“…Chronic inflammation in the kidneys and vascular wall is a major contributor to hypertension. However, the stimuli and cellular mechanisms responsible for such…”
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Mechanisms of augmented vasoconstriction induced by 5‐hydroxytryptamine in aortic rings from spontaneously hypertensive rats by Budzyn, K, Ravi, R M, Miller, A A, Sobey, C G

“…Background and purpose: To test whether development of enhanced vasoconstriction to 5‐hydroxytryptamine (5‐HT; serotonin) in SHR was temporally related to…”
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Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke by Yang-Wei Fann, D, Lee, S-Y, Manzanero, S, Tang, S-C, Gelderblom, M, Chunduri, P, Bernreuther, C, Glatzel, M, Cheng, Y-L, Thundyil, J, Widiapradja, A, Lok, K-Z, Foo, S L, Wang, Y-C, Li, Y-I, Drummond, G R, Basta, M, Magnus, T, Jo, D-G, Mattson, M P, Sobey, C G, Arumugam, T V

“…Multi-protein complexes called inflammasomes have recently been identified and shown to contribute to cell death in tissue injury. Intravenous immunoglobulin…”
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Role of potassium channels in regulation of cerebral vascular tone by Faraci, F M, Sobey, C G

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Evidence that macrophages in atherosclerotic lesions contain angiotensin II by POTTER, D. D, SOBEY, C. G, TOMPKINS, P. K, ROSSEN, J. D, HEISTAD, D. D

“…We have reported that human mononuclear leukocytes contain large amounts of angiotensin II (Ang II). The goal of the present study was to test the hypothesis…”
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NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis by Sobey, C G, Judkins, C P, Rivera, J, Lewis, C V, Diep, H, Lee, H W, Kemp-Harper, B K, Broughton, B R S, Selemidis, S, Gaspari, T A, Samuel, C S, Drummond, G R

“…Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are enzymes that generate reactive oxygen species (ROS). NOX2 activity in the vascular wall is…”
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Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter by Sobey, C G, Faraci, F M

“…The first goal of this study was to examine the hypothesis that dilatation of the basilar artery in response to activation of ATP-sensitive K+ channels is…”
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Effect of subarachnoid hemorrhage on dilatation of rat basilar artery in vivo by Sobey, C G, Heistad, D D, Faraci, F M

“…Cerebral vasodilator responses are often impaired following subarachnoid hemorrhage (SAH). Because depolarization of vascular muscle may occur after SAH, we…”
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Inhibitory effect of 4‐aminopyridine on responses of the basilar artery to nitric oxide by Sobey, Christopher G, Faraci, Frank M

“…Voltage‐dependent K+ channels are present in cerebral arteries and may modulate vascular tone. We used 200 μM 4‐aminopyridine (4‐AP), thought to be a…”
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Potassium Channel Function in Vascular Disease by Sobey, Christopher G

“…Abstract—Potassium ion (K) channel activity is a major regulator of vascular muscle cell membrane potential (Em) and is therefore an important determinant of…”
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Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation by Faraci, Frank M., Sobey, Christopher G.

“…Responses of cerebral blood vessels to nitric oxide (NO) are mediated by soluble guanylate cyclase (sGC)-dependent and potentially by sGC-independent…”
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Evidence That Expression of Inducible Nitric Oxide Synthase in Response to Endotoxin Is Augmented in Atherosclerotic Rabbits by Sobey, Christopher G, Brooks, Robert M, Heistad, Donald D

“…Atherosclerotic lesions contain monocytes/macrophages and vascular smooth muscle cells and thus may have an increased capacity for generation of nitric oxide…”
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Evidence That Rho-Kinase Activity Contributes to Cerebral Vascular Tone In Vivo and Is Enhanced During Chronic Hypertension: Comparison With Protein Kinase C by Chrissobolis, Sophocles, Sobey, Christopher G

“…ABSTRACT—The small G protein Rho and its target Rho-kinase may participate in the mechanisms underlying vascular contractile tone via inhibition of myosin…”
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Knockout Blow for Channel Identity Crisis: Vasodilation to Potassium Is Mediated via Kir2.1 by Sobey, Christopher G, Faraci, Frank M

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Cholesterol feeding enhances vasoconstrictor effects of products from rabbit polymorphonuclear leukocytes by Hart, J L, Sobey, C G, Woodman, O L

“…We have studied the vasoactive properties of products released from rabbit polymorphonuclear leukocytes (PMNs) before and after short-term (4 and 8 wk) dietary…”
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Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia by Lentz, S R, Sobey, C G, Piegors, D J, Bhopatkar, M Y, Faraci, F M, Malinow, M R, Heistad, D D

“…Elevated plasma homocyst(e)ine may predispose to complications of vascular disease. Homocysteine alters vasomotor regulatory and anticoagulant properties of…”
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Requirement for endothelium‐derived nitric oxide in vasodilatation produced by stimulation of cholinergic nerves in rat hindquarters by Loke, K.E., Sobey, C.G., Dusting, G.J., Woodman, O.L.

“…1 We aimed to determine whether nitric oxide (NO) and/or the endothelium is involved in cholinergic neurogenic vasodilatation in the rat isolated hindquarters…”
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SUBARACHNOID HAEMORRHAGE: WHAT HAPPENS TO THE CEREBRAL ARTERIES? by Sobey, Christopher G, Faraci, Frank M

“…SUMMARY 1. Subarachnoid haemorrhage (SAH) is a unique disorder and a major clinical problem that most commonly occurs when an aneurysm in a cerebral artery…”
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