Search Results - "SOARES, Andreimar M"

An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs) by Paloschi, Mauro V, Pontes, Adriana S, Soares, Andreimar M, Zuliani, Juliana P

“…LAAOs (EC 1.4.3.2) are found in concentrations that vary according to each species of snakes; Viperidae, Crotalidae and Elapidae contain 1-9% of this enzyme in…”
Get more information

Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom by Rego, Cristina M. A., Francisco, Aleff F., Boeno, Charles N., Paloschi, Mauro V., Lopes, Jéssica A., Silva, Milena D. S., Santana, Hallison M., Serrath, Suzanne N., Rodrigues, Jaína E., Lemos, Caleb T. L., Dutra, Ricardo S. S., da Cruz, Jorddy N., dos Santos, Cleydson Breno R., da S. Setúbal, Sulamita, Fontes, Marcos R. M., Soares, Andreimar M., Pires, Weverson L., Zuliani, Juliana P.

“…Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake species, Crotalus durissus terrificus , stimulates platelet aggregation by…”
Get full text

Snake Venom L-Amino Acid Oxidases : Trends in Pharmacology and Biochemistry by Zanchi, Fernando B., Zuliani, Juliana P., Fernandes, Carla F. C., Calderon, Leonardo A., Stábeli, Rodrigo G., Soares, Andreimar Martins, Izidoro, Luiz Fernando M., da Silva, Saulo Luís, Rodrigues, Veridiana M., Grabner, Amy N., Sobrinho, Juliana C., Mendes, Mirian M., Costa, Tássia R.

“…L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their…”
Get full text

Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids by Fernandes, Carlos A H, Cardoso, Fábio Florença, Cavalcante, Walter G L, Soares, Andreimar M, Dal-Pai, Maeli, Gallacci, Marcia, Fontes, Marcos R M

“…One of the main challenges in toxicology today is to develop therapeutic alternatives for the treatment of snake venom injuries that are not efficiently…”
Get full text

Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments by Prado, Nidiane D R, Pereira, Soraya S, da Silva, Michele P, Morais, Michelle S S, Kayano, Anderson M, Moreira-Dill, Leandro S, Luiz, Marcos B, Zanchi, Fernando B, Fuly, André L, Huacca, Maribel E F, Fernandes, Cleberson F, Calderon, Leonardo A, Zuliani, Juliana P, Pereira da Silva, Luiz H, Soares, Andreimar M, Stabeli, Rodrigo G, Fernandes, Carla F C

“…Antivenoms, produced using animal hyperimmune plasma, remains the standard therapy for snakebites. Although effective against systemic damages, conventional…”
Get full text

Mechanism of the cytotoxic effect of l-amino acid oxidase isolated from Bothrops alternatus snake venom by Ribeiro, Patrícia H., Zuliani, Juliana P., Fernandes, Carla F.C., Calderon, Leonardo A., Stábeli, Rodrigo G., Nomizo, Auro, Soares, Andreimar M.

“…BaltLAAO-I, an L-amino acid oxidase isolated from Bothrops alternatus, is a glycoprotein enzyme with a pI⿿5.3, 15% sugar and a related molecular mass of…”
Get full text

Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA₂ inhibition by Dos Santos, Juliana I, Cardoso, Fábio F, Soares, Andreimar M, Dal Pai Silva, Maeli, Gallacci, Márcia, Fontes, Marcos R M

“…Snakebite envenoming is an important public health problem in many tropical and subtropical countries, and is considered a neglected tropical disease by the…”
Get full text

Structural bases for a complete myotoxic mechanism: Crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom by Fernandes, Carlos A.H., Comparetti, Edson J., Borges, Rafael J., Huancahuire-Vega, Salomón, Ponce-Soto, Luis Alberto, Marangoni, Sergio, Soares, Andreimar M., Fontes, Marcos R.M.

“…Bothrops brazili is a snake found in the forests of the Amazonian region whose commercial therapeutic anti-bothropic serum has low efficacy for local myotoxic…”
Get full text

Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of Calloselasma rhodostoma Venom Action by Serrath, Suzanne N, Pontes, Adriana S, Paloschi, Mauro V, Silva, Milena D S, Lopes, Jéssica A, Boeno, Charles N, Silva, Carolina P, Santana, Hallison M, Cardozo, Daniel G, Ugarte, Andrey V E, Magalhães, João G S, Cruz, Larissa F, Setubal, Sulamita S, Soares, Andreimar M, Cavecci-Mendonça, Bruna, Santos, Lucilene D, Zuliani, Juliana P

“…L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H O ) during…”
Get full text

Venomics and antivenomics of the poorly studied Brazil's lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Pará by Sanz, Libia, Pérez, Alicia, Quesada-Bernat, Sarai, Diniz-Sousa, Rafaela, Calderón, Leonardo A, Soares, Andreimar M, Calvete, Juan J, Caldeira, Cleópatra A S

“…The Brazil's lancehead, , is a poorly studied pit viper distributed in lowlands of the equatorial rainforests of southern Colombia, northeastern Peru, eastern…”
Get full text

Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives by Simoes-Silva, Rodrigo, Alfonso, Jorge, Gomez, Ana, Holanda, Rudson J, Sobrinho, Juliana C, Zaqueo, Kayena D, Moreira-Dill, Leandro S, Kayano, Anderson M, Grabner, Fernando P, da Silva, Saulo L, Almeida, Jose R, Stabeli, Rodrigo G, Zuliani, Juliana P, Soares, Andreimar M

“…Research involving snake venom has gradually surpassed the simple discovery of new molecules using purification and structural characterization processes, and…”
Get more information

Biodiversity as a source of bioactive compounds against snakebites by Guimaraes, Cesar L S, Moreira-Dill, Leandro S, Fernandes, Renata S, Costa, Tassia R, Hage-Melim, Lorane I S, Marcussi, Silvana, Carvalho, Bruna M A, da Silva, Saulo L, Zuliani, Juliana P, Fernandes, Carla F C, Calderon, Leonardo A, Soares, Andreimar M, Stabeli, Rodrigo G

“…Snakebites are a frequently neglected public health issue in tropical and subtropical countries. According to the World Health Organization, 5 million people…”
Get more information

A novel synthetic quinolinone inhibitor presents proteolytic and hemorrhagic inhibitory activities against snake venom metalloproteases by Baraldi, Patrícia T., Magro, Angelo J., Matioli, Fábio F., Marcussi, Silvana, Lemke, Ney, Calderon, Leonardo A., Stábeli, Rodrigo G., Soares, Andreimar M., Correa, Arlene G., Fontes, Marcos R.M.

“…Metalloproteases play a fundamental role in snake venom envenomation inducing hemorrhagic, fibrigen(ogen)olytic and myotoxic effects in their victims. Several…”
Get full text

Camelid Single-Domain Antibodies (VHHs) against Crotoxin: A Basis for Developing Modular Building Blocks for the Enhancement of Treatment or Diagnosis of Crotalic Envenoming by Luiz, Marcos B, Pereira, Soraya S, Prado, Nidiane D R, Gonçalves, Naan R, Kayano, Anderson M, Moreira-Dill, Leandro S, Sobrinho, Juliana C, Zanchi, Fernando B, Fuly, André L, Fernandes, Cleberson F, Zuliani, Juliana P, Soares, Andreimar M, Stabeli, Rodrigo G, Fernandes, Carla F C

“…Toxic effects triggered by crotalic envenoming are mainly related to crotoxin (CTX), composed of a phospholipase A₂ (CB) and a subunit with no toxic activity…”
Get full text

Novel camelid antibody fragments targeting recombinant nucleoprotein of Araucaria hantavirus: a prototype for an early diagnosis of Hantavirus Pulmonary Syndrome by Pereira, Soraya S, Moreira-Dill, Leandro S, Morais, Michelle S S, Prado, Nidiane D R, Barros, Marcos L, Koishi, Andrea C, Mazarrotto, Giovanny A C A, Gonçalves, Giselle M, Zuliani, Juliana P, Calderon, Leonardo A, Soares, Andreimar M, Pereira da Silva, Luiz H, Duarte dos Santos, Claudia N, Fernandes, Carla F C, Stabeli, Rodrigo G

“…In addition to conventional antibodies, camelids produce immunoglobulins G composed exclusively of heavy chains in which the antigen binding site is formed…”
Get full text

Antimalarial activity of basic phospholipases A2 isolated from Paraguayan Bothrops diporus venom against Plasmodium falciparum by Vitorino, Keila A., Alfonso, Jorge J., Gómez, Ana F., Santos, Ana Paula A., Antunes, Ygor R., Caldeira, Cleópatra A. da S., Gómez, Celeste V., Teles, Carolina B.G., Soares, Andreimar M., Calderon, Leonardo A.

“…Malaria is a parasitic infectious disease and was responsible for 400.000 deaths in 2018. Plasmodium falciparum represents the species that causes most human…”
Get full text

Protective effect of schizolobium parahyba flavonoids against snake venoms and isolated toxins by F Vale, Luis Henrique, Mendes, Mirian M, Fernandes, Renata S, Costa, Tassia R, S Hage-Melim, Lorane I, A Sousa, Maicon, Hamaguchi, Amelia, Homsi-Brandeburgo, Maria I, Franca, Suzelei C, Silva, Carlos H T P, Pereira, Paulo S, Soares, Andreimar M, Rodrigues, Veridiana M

“…Four compounds (isoquercitrin, myricetin-3-O-glucoside, catechin and gallocatechin) were isolated from lyophilized aqueous extract of Schizolobium parahyba…”
Get more information

Human neutrophils functionality under effect of an Asp49 phospholipase A2 isolated from Bothrops atrox venom by Setúbal, Sulamita da S., Pontes, Adriana S., Nery, Neriane M., Rego, Cristina M.A., Santana, Hallison M., de Lima, Anderson M., Boeno, Charles N., Paloschi, Mauro V., Soares, Andreimar M., Zuliani, Juliana P.

“…Bothrops envenomation is associated with a cellular inflammatory response, characterized by pronounced neutrophil infiltration at the site of injury…”
Get full text

Antitumoral Potential of Snake Venom Phospholipases A2 and Synthetic Peptides by Sobrinho, Juliana C, Simões-Silva, Rodrigo, Holanda, Rudson J, Alfonso, Jorge, Gomez, Ana F, Zanchi, Fernando B, Moreira-Dill, Leandro S, Grabner, Amy N, Zuliani, Juliana P, Calderon, Leonardo A, Soares, Andreimar M

“…Cancer, a disease that currently affects approximately 14 million people, is characterized by abnormal cell growth with altered replication capacity, which…”
Get more information

Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity by González Rodríguez, Isela I., Francisco, Aleff F., Moreira-Dill, Leandro S., Quintero, Aristides, Guimarães, César L.S., Fernandes, Carlos A.H., Takeda, Agnes A.S., Zanchi, Fernando B., Caldeira, Cléopatra A.S., Pereira, Paulo S., Fontes, Marcos R.M., Zuliani, Juliana P., Soares, Andreimar M.

“…A bioactive compound isolated from the stem extract of Aristolochia sprucei through High Performance Liquid Chromatography (HPLC) was identified via Nuclear…”
Get full text