Effects of allogeneic bone marrow transplantation on pulmonary function in 80 children in a single paediatric centre

We retrospectively reviewed the results of serial pulmonary function tests (PFT) after allogeneic bone marrow transplantation (BMT) performed in 80 children at a single institution over a 16-year period. We looked for associations linking PFT results to graft-versus-host disease (GVHD), conditioning...

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Bibliographic Details
Published in:	Bone marrow transplantation (Basingstoke) Vol. 34; no. 2; pp. 143 - 147
Main Authors:	BRUNO, B, SOUILLET, G, BERTRAND, Y, WERCK-CALLOIS, M. C, SO SATTA, A, BELLON, G
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-07-2004
Subjects:	Adolescent Airway management Airway Obstruction Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - methods Bone marrow, stem cells transplantation. Graft versus host reaction Busulfan Busulfan - toxicity Child Child, Preschool Children Complications and side effects Conditioning Cytomegalovirus Cytomegalovirus - immunology Dosage and administration Forced Expiratory Volume Graft versus host disease Graft versus host reaction Graft vs Host Disease - complications Graft vs Host Disease - etiology Health aspects Humans Immune status Irradiation Medical sciences Methods Physiological aspects Prevention Pulmonary functions Radiation Respiration Respiratory function Respiratory Function Tests Retrospective Studies Risk factors Side effects Stem cell transplantation Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - adverse effects Transplantation Conditioning - methods Transplantation, Homologous Vital Capacity Whole-Body Irradiation - adverse effects France Antineoplastic agent Stem cell Hematopoietic cell Homograft Betaherpesvirinae Lung function Bone marrow Graft Busulfan Child Human Immunopathology Cytomegalovirus Total body irradiation Herpesviridae Alkanediol pulmonary function Graft versus host reaction busulphan Infection Virus Alkanesulfonic acid Alkylating agent Viral disease graft versus host disease
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Summary:	We retrospectively reviewed the results of serial pulmonary function tests (PFT) after allogeneic bone marrow transplantation (BMT) performed in 80 children at a single institution over a 16-year period. We looked for associations linking PFT results to graft-versus-host disease (GVHD), conditioning regimen (total body irradiation (TBI) vs busulphan), and cytomegalovirus immune status. The median follow-up after BMT was 4 years. At 2 years after BMT, significant declines were found in forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), as compared to baseline. Both FEV1 and the FEV1/FVC ratio showed significantly greater reductions in the group conditioned with busulphan (n=22) than in the group conditioned with TBI (n=49) and were significantly lower in the patients with (n=16) than without (n=64) chronic GVHD. Busulphan may be associated with greater long-term lung toxicity than TBI. The relevance of this finding to selection of conditioning regimens for BMT should be examined in the light of the overall pattern of side effects. Chronic GVHD was associated with airway obstruction.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1704549