Search Results - "SO, WING YAN"

IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion by Lin, Hong, Yan, Yuan, Luo, Yifan, So, Wing Yan, Wei, Xiayun, Zhang, Xiaozhe, Yang, Xiaoli, Zhang, Jun, Su, Yang, Yang, Xiuyan, Zhang, Bobo, Zhang, Kangjun, Jiang, Nan, Chow, Billy Kwok Chong, Han, Weiping, Wang, Fengchao, Rao, Feng

“…COP1 and COP9 signalosome (CSN) are the substrate receptor and deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear…”
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Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states by Zhang, Dan, So, Wing Yan, Wang, Yi, Wu, Shang Ying, Cheng, Qianni, Leung, Po Sing

“…G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120…”
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Spatialization Design: Comparing Points and Landscapes by Tory, M., Sprague, D.W., Fuqu Wu, Wing Yan So, Munzner, T.

“…Spatializations represent non-spatial data using a spatial layout similar to a map. We present an experiment comparing different visual representations of…”
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Gender differences in the relationships between meaning in life, mental health status and digital media use during Covid-19 by So, Wendy Wing Yan, Woo, Bowie Po Yi, Wong, Clifford, Yip, Paul Siu Fai

“…Background The COVID-19 pandemic has had a significant impact on individuals' social lives, mental health status, and meaning in life (MIL). Globally, the use…”
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Estrogen Controls embryonic stem cell proliferation via store-operated calcium entry and the nuclear factor of activated T-cells (NFAT) by Wong, Chun-Kit, So, Wing-Yan, Law, Sau-Kwan, Leung, Fung-Ping, Yau, Ka-Long, Yao, Xiaoqiang, Huang, Yu, Li, Xiangdong, Tsang, Suk-Ying

“…Embryonic stem cells (ESCs) can self‐renew indefinitely and differentiate into all cell lineages. Calcium is a universal second messenger which regulates a…”
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Gene therapy targeting key beta cell regulators as a potential intervention for diabetes by So, Wing Yan, Han, Weiping

“…Loss of functional beta cells is the central event of all forms of diabetes. Conventional therapies for type 2 diabetes (T2D) fail to preserve beta cells,…”
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Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus by So, Wing Yan, Leung, Po Sing

“…Fibroblast growth factor (FGF) 21 is a distinctive member of the FGF family that functions as an endocrine factor. It is expressed predominantly in the liver,…”
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Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism by Xie, Ting, So, Wing Yan, Li, Xing Yu, Leung, Po Sing

“…Fibroblast growth factor 21 (FGF21) is known as a potent metabolic regulator but its protective mechanisms against lipotoxicity-induced β-cell dysfunction and…”
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Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy by So, Wing Yan, Liao, Yilie, Liu, Wai Nam, Rutter, Guy A, Han, Weiping

“…Loss of pancreatic beta cells is the central feature of all forms of diabetes. Current therapies fail to halt the declined beta cell mass. Thus, strategies to…”
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High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor γ Signaling by WING YAN SO, QIANNI CHENG, LIHUA CHEN, EVANS-MOLINA, Carmella, AIMIN XU, LAM, Karen S. L, PO SING LEUNG

“…Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and correlate directly with abnormal glucose metabolism, while…”
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The Neurophysiological and Psychological Mechanisms of Qigong as a Treatment for Depression: A Systematic Review and Meta-Analysis by So, Wendy Wing Yan, Cai, Shuhe, Yau, Suk Yu, Tsang, Hector Wing Hong

“…An increasing number of studies have shown the anti-depressive effect of qigong. However, its underlying mechanism remains poorly understood. This study aims…”
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Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways by Lee, Cheuk-Lun, Sit, Wai-Hung, Jiang, Ping-Ping, So, Ivy Wing-Yan, Wan, Jennifer Man-Fan

“…The activation of T helper (Th) cell subsets plays an important role in the human immune system. Uncontrolled Th1 and Th2 responses lead to autoimmune and…”
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Qigong for the treatment of depressive symptoms: Preliminary evidence of neurobiological mechanisms by Lu, Erin Yiqing, Lee, Posen, Cai, Shuhe, So, Wendy Wing Yan, Ng, Bacon Fung Leung, Jensen, Mark P., Cheung, Wai Ming, Tsang, Hector W. H.

“…Objectives Qigong has been shown to effectively reduce depressive symptoms in older adults with chronic physical illness. Here, we sought to evaluate the…”
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Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling by So, Wing Yan, Leung, Po Sing

“…•Irisin activates LKB1/AMPK signaling pathway in HepG2 cells.•Irisin ameliorates derangement of lipid and glucose metabolism via AMPK activation.•Irisin…”
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Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis by So, Wing Yan, Liu, Wai Nam, Teo, Adrian Kee Keong, Rutter, Guy A, Han, Weiping

“…The paired box 6 (PAX6) transcription factor is crucial for normal pancreatic islet development and function. Heterozygous mutations of are associated with…”
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Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets by Chen, Lihua, So, Wing Yan, Li, Stephen Y.T., Cheng, Qianni, Boucher, Barbara J., Leung, Po Sing

“…•Long-term treatment with niacin induced hyperglycemia and impaired glucose homeostasis.•Long-term treatment with niacin impaired pancreatic islet function via…”
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Successful targeting of PD-1/PD-L1 with chimeric antigen receptor-natural killer cells and nivolumab in a humanized mouse cancer model by Liu, Wai Nam, So, Wing Yan, Harden, Sarah L, Fong, Shin Yie, Wong, Melissa Xin Yu, Tan, Wilson Wei Sheng, Tan, Sue Yee, Ong, Jessica Kai Lin, Rajarethinam, Ravisankar, Liu, Min, Cheng, Jia Ying, Suteja, Lisda, Yeong, Joe Poh Sheng, Iyer, N Gopalakrishna, Lim, Darren Wan-Teck, Chen, Qingfeng

“…In recent decades, chimeric antigen receptor (CAR)-engineered immune effector cells have demonstrated promising antileukemic activity. Nevertheless, their…”
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Psychosocial and financial well-being mediated the effects of COVID-19 distress on suicidality: a serial mediation model among Hong Kong young adults by So, Wendy Wing Yan, Fong, Ted Chun Tat, Woo, Bowie Po Yi, Yip, Paul Siu Fai

“…Purpose The COVID-19 pandemic has brought significant distress on not only the physical health but also mental health of individuals. The present study…”
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High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets by So, Wing Yan, Cheng, Qianni, Chen, Lihua, Evans-Molina, Carmella, Xu, Aimin, Lam, Karen S.L., Leung, Po Sing

“…Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and correlate directly with abnormal glucose metabolism, while…”
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IP 6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion by Lin, Hong, Yan, Yuan, Luo, Yifan, So, Wing Yan, Wei, Xiayun, Zhang, Xiaozhe, Yang, Xiaoli, Zhang, Jun, Su, Yang, Yang, Xiuyan, Zhang, Bobo, Zhang, Kangjun, Jiang, Nan, Chow, Billy Kwok Chong, Han, Weiping, Wang, Fengchao, Rao, Feng

“…COP1 and COP9 signalosome (CSN) are the substrate receptor and deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear…”
Get full text