Search Results - "SNYDER, S. H"

The unusual amino acid L-ergothioneine is a physiologic cytoprotectant by Paul, B D, Snyder, S H

“…Ergothioneine (ET) is an unusual sulfur-containing derivative of the amino acid, histidine, which is derived exclusively through the diet. Although ET was…”
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Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion by Ma, T M, Abazyan, S, Abazyan, B, Nomura, J, Yang, C, Seshadri, S, Sawa, A, Snyder, S H, Pletnikov, M V

“…Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D -serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia…”
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Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation by Harraz, M M, Tyagi, R, Cortés, P, Snyder, S H

“…As traditional antidepressants act only after weeks/months, the discovery that ketamine, an antagonist of glutamate/ N -methyl- d -aspartate (NMDA) receptors,…”
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Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways by Chakraborty, A, Latapy, C, Xu, J, Snyder, S H, Beaulieu, J-M

“…Glycogen synthase kinase 3 (GSK3), a prominent enzyme in carbohydrate metabolism, also has a major role in brain function. It is physiologically regulated by…”
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Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior by Basu, A C, Tsai, G E, Ma, C-L, Ehmsen, J T, Mustafa, A K, Han, L, Jiang, Z I, Benneyworth, M A, Froimowitz, M P, Lange, N, Snyder, S H, Bergeron, R, Coyle, J T

“…A subset of glutamate receptors that are specifically sensitive to the glutamate analog N -methyl- D -aspartate (NMDA) are molecular coincidence detectors,…”
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Serine racemase binds to PICK1: potential relevance to schizophrenia by Fujii, K, Maeda, K, Hikida, T, Mustafa, A K, Balkissoon, R, Xia, J, Yamada, T, Ozeki, Y, Kawahara, R, Okawa, M, Huganir, R L, Ujike, H, Snyder, S H, Sawa, A

“…Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate…”
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Poly(ADP-Ribose) Polymerase Is a Mediator of Necrotic Cell Death by ATP Depletion by Ha, Hyo Chol, Snyder, Solomon H.

“…Apoptotic and necrotic cell death are well characterized and are influenced by intracellular ATP levels. Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme…”
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Nitric Oxide: A Physiologic Messenger Molecule by Bredt, D S, Snyder, S H

“…Nitric oxide was first implicated in the brain when cerebellar cultures stimulated by excitatory amino acids were found to release a substance with the…”
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d-Aspartate disposition in neuronal and endocrine tissues: ontogeny, biosynthesis and release by Wolosker, H, D’Aniello, A, Snyder, S.H

“…High levels of d-aspartate occur in the brain and endocrine glands, such as pineal, adrenal and pituitary. In the brain, d-aspartate levels are highest in…”
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Carbon Monoxide and Nitric Oxide as Coneurotransmitters in the Enteric Nervous System: Evidence from Genomic Deletion of Biosynthetic Enzymes by Xue, L., Farrugia, G., Miller, S. M., Ferris, C. D., Snyder, S. H., Szurszewski, J. H.

“…Nitric oxide (NO) and carbon monoxide (CO) seem to be neurotransmitters in the brain. The colocalization of their respective biosynthetic enzymes, neuronal NO…”
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Nitric Oxide: First in a New Class of Neurotransmitters? by Snyder, Solomon H.

“…Nitric oxide (NO) is often confused with the chemically distinct nitrous oxide (N2O), which is used as an anesthetic and is chemically stable. NO's function as…”
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Isolation of Nitric Oxide Synthetase, a Calmodulin-Requiring Enzyme by Bredt, David S., Snyder, Solomon H.

“…Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of macrophages and neutrophils, and influences of excitatory amino…”
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Novel Neurotransmitters and Their Neuropsychiatric Relevance by Snyder, Solomon H., Ferris, Christopher D.

“…OBJECTIVE: The purpose of this review is to integrate insights regarding novel neurotransmitters or neuromodulators of neuropsychiatric significance. METHOD:…”
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Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures by Dawson, VL, Dawson, TM, Bartley, DA, Uhl, GR, Snyder, SH

“…In addition to mediating several physiological functions, nitric oxide (NO) has been implicated in the cytotoxicities observed following activation of…”
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Nitric oxide, a novel biologic messenger by Lowenstein, C J, Snyder, S H

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Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity by Blackshaw, S, Eliasson, M.J.L, Sawa, A, Watkins, C.C, Krug, D, Gupta, A, Arai, T, Ferrante, R.J, Snyder, S.H

“…Nitric oxide (NO) has been implicated in long-term potentiation (LTP) in pyramidal neurons in cellular area 1 (CA1) of the hippocampus. However, considerable…”
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Targeted disruption of the neuronal nitric oxide synthase gene by Huang, P L, Dawson, T M, Bredt, D S, Snyder, S H, Fishman, M C

“…By homologous recombination, we have generated mice that lack the neuronal nitric oxide synthase (NOS) gene. Neuronal NOS expression and NADPH-diaphorase (NDP)…”
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Macrophage Nitric Oxide Synthase Gene: Two Upstream Regions Mediate Induction by Interferon γ and Lipopolysaccharide by Lowenstein, Charles J., Alley, Evan W., Raval, Prafulla, Snowman, Adele M., Snyder, Solomon H., Russell, Stephen W., Murphy, William J.

“…The promoter region of the mouse gene for macrophage-inducible nitric oxide synthase (mac-NOS; EC 1.14.13.39) has been characterized. A putative TATA box is 30…”
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Nitric Oxide Mediates Glutamate Neurotoxicity in Primary Cortical Cultures by Dawson, Valina L., Dawson, Ted M., London, Edythe D., Bredt, David S., Snyder, Solomon H.

“…Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels, cytotoxicity of activated macrophages, and formation of cGMP by…”
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Nitric oxide in the nervous system by Zhang, J, Snyder, S H

“…Nitric oxide (NO) has only recently been appreciated as a normal biologic substance with a role in signal transduction. It was first identified as…”
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