Search Results - "SNOWDEN, R. T"

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation by COHEN, G. M, SUN, X.-M, SNOWDEN, R. T, DINSDALE, D, SKILLETER, D. N

“…Apoptosis, a major form of cell death, is characterized by chromatin condensation, a reduction in cell volume and endonuclease cleavage of DNA into…”
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CDDO induces apoptosis via the intrinsic pathway in lymphoid cells by INOUE, S, SNOWDEN, R. T, DYER, M. J. S, COHEN, G. M

“…The peroxisome-proliferator-activated receptor (PPAR) gamma agonist, CDDO, is under investigation for use in various malignancies. The mechanisms by which CDDO…”
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Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an ∼700 kDa Apaf-1 containing apoptosome complex by ALMOND, J. B, SNOWDEN, R. T, HUNTER, A, DINSDALE, D, CAIN, K, COHEN, G. M

“…Proteasome inhibitors, including lactacystin and MG132 (carbobenzoxyl-leucinyl-leucinyl-leucinal), potently induce apoptosis in leukaemic B cells from patients…”
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Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1 by SNOWDEN, R. T, SUN, X-M, DYER, M. J. S, COHEN, G. M

“…New agents are required for the treatment of chronic lymphocytic leukaemia (CLL). We show here that a protein kinase C inhibitor, bisindolylmaleimide IX, is a…”
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Surgical correction of entrapment of the large colon and caecum through a mesoduodenal rent with standing laparoscopic repair in a mare by Cypher, E. E., Blackford, J., Snowden, R. T., Sexton, J. A., Schumacher, J.

“…Summary A 12‐year‐old Tennessee Walking Horse mare displaying signs of severe colic for 48 h was found during an exploratory celiotomy to have entrapment of a…”
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Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes by Cohen, GM, Sun, XM, Fearnhead, H, MacFarlane, M, Brown, DG, Snowden, RT, Dinsdale, D

“…Apoptosis is a process in which cells die in a controlled manner and apparently participate in their own demise. It is best characterized morphologically by…”
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A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes by Sun, X M, Snowden, R T, Skilleter, D N, Dinsdale, D, Ormerod, M G, Cohen, G M

“…Using flow cytometry, we describe a method for separating and quantifying normal and apoptotic thymocytes. Apoptosis was induced in isolated thymocytes from…”
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Apoptosis as a mechanism of tributyltin cytotoxicity to thymocytes: relationship of apoptotic markers to biochemical and cellular effects by Raffray, M, McCarthy, D, Snowden, R T, Cohen, G M

“…Recent in vitro studies have suggested that activation of apoptosis could account for the profound depletion of cortical thymocytes, which characterizes…”
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Identification of a transitional preapoptotic population of thymocytes [published erratum appears in J Immunol 1993 Dec 1;151(11):6616] by Cohen, GM, Sun, XM, Snowden, RT, Ormerod, MG, Dinsdale, D

“…Apoptosis, a major form of cell death in the immune system, is characterized by cell shrinkage, chromatin condensation, and cleavage into nucleosomal…”
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Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia by MACFARLANE, Marion, HARPER, Nicholas, SNOWDEN, Roger T, DYER, Martin J. S, BARNETT, Georgina A, PRINGLE, J. Howard, COHEN, Gerald M

“…Primary B cells from B cell chronic lymphocytic leukaemia (B-CLL) were resistant to the novel selective cytotoxic agent, TNF-related apoptosis-inducing ligand…”
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Formation of high molecular mass DNA fragments is a marker of apoptosis in the human leukaemic cell line, U937 by BICKNELL, G. R, SNOWDEN, R. T, COHEN, G. M

“…Inhibitors of macromolecular synthesis and topoisomerases induce apoptosis in the human leukaemic cell line, U937. In this study, U937 cells were treated with…”
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Impact of acute epinephrine removal on hepatic glucose metabolism during stress hormone infusion by McGuinness, Owen P., Snowden, Robert T., Moran, Christopher, Neal, Doss W., Fujiwara, Toshiko, Cherrington, Alan D.

“…We examined the effect of acute discontinuation of an epinephrine (EPI) infusion on hepatic glucose metabolism during stress hormone infusion (SHI). Glucose…”
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Hyaline droplet accumulation in rodent kidney proximal tubules: an association with histiocytic sarcoma by Hard, G C, Snowden, R T

“…Since recognition during the last decade that certain renal carcinogens can initially cause an accumulation of hyaline (protein) droplets in proximal tubules…”
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Changes in nuclear chromatin precede internucleosomal DNA cleavage in the induction of apoptosis by etoposide by Sun, X M, Snowden, R T, Dinsdale, D, Ormerod, M G, Cohen, G M

“…Etoposide, a DNA topoisomerase II inhibitor, caused a concentration-dependent induction of apoptosis in immature thymocytes. Using a flow cytometric method to…”
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The comparative toxicology of ethyl- and methylmercury by MAGOS, L, BROWN, A. W, SPARROW, S, BAILEY, E, SNOWDEN, R. T, SKIPP, W. R

“…Neurotoxicity and renotoxicity were compared in rats given by gastric gavage five daily doses of 8.0 mg Hg/kg methyl- or ethylmercuric chloride or 9.6 mg Hg/kg…”
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Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells by DEWSON, Grant, SNOWDEN, Roger T, ALMOND, Jason B, DYER, Martin J. S, COHEN, Gerald M

“…Chemotherapy resistance remains a major clinical problem in patients with B-cell chronic lymphocytic leukemia (B-CLL). Proteasome inhibitors are able to induce…”
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Quantification of apoptosis and necrosis by flow cytometry by Ormerod, M G, Sun, X M, Brown, D, Snowden, R T, Cohen, G M

“…Apoptosis and necrosis are two important mechanisms of cell death. Several methods have recently been described for quantifying apoptotic cells by flow…”
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Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle by Fearnhead, H O, Chwalinski, M, Snowden, R T, Ormerod, M G, Cohen, G M

“…Dexamethasone and etoposide both induce apoptosis in immature rat thymocytes. We investigated the dependence of apoptosis on the phase of the cell cycle after…”
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Characterization of apoptosis in thymocytes isolated from dexamethasone-treated rats by Sun, X M, Dinsdale, D, Snowden, R T, Cohen, G M, Skilleter, D N

“…The induction of apoptosis by glucocorticoids in isolated thymocytes has been studied extensively. However, it is not known whether or not the same changes…”
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Antioxidants can delay liver cell maturation which in turn affects gamma-glutamyltranspeptidase expression by Davies, R, Edwards, R E, Green, J A, Legg, R F, Snowden, R T, Manson, M M

“…In normal rats just before weaning the majority of hepatocytes are mononucleated diploids, but within days the number of binucleated cells reaches a peak…”
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