Search Results - "SNEL, C. A. W"

The Metabolism and Excretion of Galantamine in Rats, Dogs, and Humans by MANNENS, G. S. J, SNEL, C. A. W, VAN PEER, A, MEULDERMANS, W, HENDRICKX, J, VERHAEGHE, T, LE JEUNE, L, BODE, W, VAN BEIJSTERVELDT, L, LAVRIJSEN, K, LEEMPOELS, J, VAN OSSELAER, N

“…Galantamine is a competitive acetylcholine esterase inhibitor with a beneficial therapeutic effect in patients with Alzheimer's disease. The metabolism and…”
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Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl )-1-methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor by GARNER, R. C, GORIS, I, SNEL, C. A. W, LAENEN, A. A. E, VANHOUTTE, E, MEULDERMANS, W, GREGORY, S, GARNER, J. V, LEONG, D, WHATTAM, M, CALAM, A

“…Accelerator mass spectrometry (AMS) has been used in a human mass balance and metabolism study to analyze samples taken from four healthy male adult subjects…”
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Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study–Experience with 14 C-labeled ( R )-6-[Amino(4- chlorophenyl)(1-methyl-1 H -imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1 H )-quinolinone (R115777), a Farnesyl Transferase Inhibitor by Garner, R. C., Goris, I., Laenen, A. A. E., Vanhoutte, E., Meuldermans, W., Gregory, S., Garner, J. V., Leong, D., Whattam, M., Calam, A., Snel, C. A. W.

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Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study–Experience with14C-labeled (R)-6-[Amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a Farnesyl Transferase Inhibitor by R. C. Garner, I. Goris, A. A. E. Laenen, E. Vanhoutte, W. Meuldermans, S. Gregory, J. V. Garner, D. Leong, M. Whattam, A. Calam, C. A. W. Snel

“…Accelerator mass spectrometry (AMS) has been used in a human mass balance and metabolism study to analyze samples taken from four healthy male adult subjects…”
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Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver by Snel, C A, Pang, K S, Mulder, G J

“…The relation between the rate of glutathione (GSH) conjugation and hepatic GSH content was studied in the rat in vivo and the in situ single-pass-perfused rat…”
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Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids by Snel, C A, Zhao, Y, Mulder, G J, Pang, K S

“…This paper describes a solvent-gradient HPLC method which was developed for the quantitation of bromosulfophthalein (BSP) in erythrocyte and albumin containing…”
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Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique by Zhao, Y, Snel, C A, Mulder, G J, Pang, K S

“…The plasma binding and conjugation kinetics of bromosulfophthalein (BSP) with glutathione (GSH) were studied in the single-pass in situ perfused rat liver…”
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