Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer

Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer

Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on...

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Bibliographic Details
Published in:International journal of radiation biology Vol. 73; no. 6; pp. 661 - 670
Main Authors: RUSSELL, N.S, GRUMMELS, A, HART, A.A.M, SMOLDERS, I.J.H, BORGER, J, BARTELINK, H, BEGG, A. C.
Format: Journal Article
Language:English
Published: London Informa UK Ltd 1998
Taylor & Francis
Subjects:
Age Factors
Analysis of Variance
Biological and medical sciences
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Cell Survival - radiation effects
Cells, Cultured
Chemotherapy, Adjuvant
Cobalt Radioisotopes
Female
Fibroblasts - pathology
Fibroblasts - radiation effects
Fibrosis
Follow-Up Studies
Gamma Rays
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Predictive Value of Tests
Radiotherapy - adverse effects
Radiotherapy Dosage
Reproducibility of Results
Retrospective Studies
Risk Factors
Skin - pathology
Skin - radiation effects
Time Factors
Tumors
Human
Radiosensitivity
Malignant tumor
Radiotherapy
In vitro
Mammary gland diseases
Clonogenic assay
Treatment
Risk factor
Fibrosis
Female
Mammary gland
Fibroblast
Survival curve
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Summary:Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on observed fibrosis and seven identified clinical risk factors for fibrosis development. In vitro radiosensitivity of patients' dermal fibroblasts was determined by clonogenic assay of early passage cultures. Survival was determined after irradiation at 0, 2 and 4 Gy, given in two fractions of 2 Gy with a 6 h interval. Results: There was a significant inter-patient variation for SF2 values (coefficient of variation 40%). The ratio of SF2 values for fibroblasts from patients with breast fibrosis versus those without was 0.80 (95% CI: 0.60-1.07). This was a statistically non-significant trend (p 0.13). The same ratio for a derived value for SF2 ((SF2 SF4)/2) was 0.88 (p 0.19). Conclusions: A significant variation in intrinsic radiosensitivity of breast cancer patients' dermal fibroblasts was observed. However, the degree of radiosensitivity did not show a significant correlation with fibrosis development. This indicates that the use of fibroblast radiosensitivity will have a limited usefulness for predicting fibrosis following breast irradiation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0955-3002
1362-3095
DOI:10.1080/095530098141915