Search Results - "SMITHGALL, Thomas E"

MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation by Garg, Abhishek V., Amatya, Nilesh, Chen, Kong, Cruz, J. Agustin, Grover, Prerna, Whibley, Natasha, Conti, Heather R., Hernandez Mir, Gerard, Sirakova, Tatiana, Childs, Erin C., Smithgall, Thomas E., Biswas, Partha S., Kolls, Jay K., McGeachy, Mandy J., Kolattukudy, Pappachan E., Gaffen, Sarah L.

“…Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We…”
Get full text

Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity by Perrone, Rosalba, Nadai, Matteo, Poe, Jerrod A, Frasson, Ilaria, Palumbo, Manlio, Palù, Giorgio, Smithgall, Thomas E, Richter, Sara N

“…G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in…”
Get full text

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways by Lee, Judong, Su, Ee Wern, Zhu, Chen, Hainline, Sarah, Phuah, Jiayao, Moroco, Jamie A., Smithgall, Thomas E., Kuchroo, Vijay K., Kane, Lawrence P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes by Staudt, Ryan P., Alvarado, John J., Emert-Sedlak, Lori A., Shi, Haibin, Shu, Sherry T., Wales, Thomas E., Engen, John R., Smithgall, Thomas E.

“…Antiretroviral therapy has revolutionized the treatment of AIDS, turning a deadly disease into a manageable chronic condition. Life-long treatment is required…”
Get full text

Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission by Roy, Chandra N., Shu, Sherry T., Kline, Christopher, Rigatti, Lora, Smithgall, Thomas E., Ambrose, Zandrea

“…Humanized mice have been used to study human immunodeficiency virus type 1 (HIV-1) transmission, pathogenesis, and treatment. The ability of pediatric thymus…”
Get full text

Structure and Dynamic Regulation of Abl Kinases by Panjarian, Shoghag, Iacob, Roxana E., Chen, Shugui, Engen, John R., Smithgall, Thomas E.

“…The c-abl proto-oncogene encodes a unique protein-tyrosine kinase (Abl) distinct from c-Src, c-Fes, and other cytoplasmic tyrosine kinases. In normal cells,…”
Get full text

Human trophoblasts confer resistance to viruses implicated in perinatal infection by Bayer, Avraham, BSc, Delorme-Axford, Elizabeth, PhD, Sleigher, Christie, MS, Frey, Teryl K., PhD, Trobaugh, Derek W., PhD, Klimstra, William B., PhD, Emert-Sedlak, Lori A., PhD, Smithgall, Thomas E., PhD, Kinchington, Paul R., PhD, Vadia, Stephen, PhD, Seveau, Stephanie, PhD, Boyle, Jon P., PhD, Coyne, Carolyn B., PhD, Sadovsky, Yoel, MD

“…Objective Primary human trophoblasts were previously shown to be resistant to viral infection, and able to confer this resistance to nontrophoblast cells. Can…”
Get full text

Expression of a Src Family Kinase in Chronic Myelogenous Leukemia Cells Induces Resistance to Imatinib in a Kinase-dependent Manner by Pene-Dumitrescu, Teodora, Smithgall, Thomas E.

“…The Bcr-Abl kinase inhibitor imatinib is remarkably effective in chronic myelogenous leukemia (CML), although drug resistance is an emerging problem. Myeloid…”
Get full text

Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance by Patel, Ravi K, Weir, Mark C, Shen, Kexin, Snyder, Daniel, Cooper, Vaughn S, Smithgall, Thomas E

“…Unregulated protein-tyrosine kinase signaling is a common feature of AML, often involving mutations in Flt3 and overexpression of myeloid Src-family kinases…”
Get full text

Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1 by Tan, Rong, Nakajima, Satoshi, Wang, Qun, Sun, Hongxiang, Xue, Jing, Wu, Jian, Hellwig, Sabine, Zeng, Xuemei, Yates, Nathan A., Smithgall, Thomas E., Lei, Ming, Jiang, Yu, Levine, Arthur S., Su, Bing, Lan, Li

“…Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is…”
Get full text

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth by Weir, Mark C, Hellwig, Sabine, Tan, Li, Liu, Yao, Gray, Nathanael S, Smithgall, Thomas E

“…Acute myelogenous leukemia (AML) is often associated with activating mutations in the receptor tyrosine kinase, Flt3, including internal tandem duplications…”
Get full text

The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner by Tarafdar, Sreya, Poe, Jerrod A., Smithgall, Thomas E.

“…The HIV-1 Nef virulence factor interacts with multiple host cell-signaling proteins. Nef binds to the Src homology 3 domains of Src family kinases, resulting…”
Get full text

Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo by Weir, Mark C, Shu, Sherry T, Patel, Ravi K, Hellwig, Sabine, Chen, Li, Tan, Li, Gray, Nathanael S, Smithgall, Thomas E

“…Acute myelogenous leukemia (AML) is the most common hematologic malignancy in adults and is often associated with constitutive tyrosine kinase signaling. These…”
Get full text

HIV-1 Nef Selectively Activates Src Family Kinases Hck, Lyn, and c-Src through Direct SH3 Domain Interaction by Trible, Ronald P., Emert-Sedlak, Lori, Smithgall, Thomas E.

“…Nef is an HIV-1 virulence factor that promotes viral pathogenicity by altering host cell signaling pathways. Nef binds several members of the Src kinase…”
Get full text

HIV-1 Nef Dimerization Is Required for Nef-Mediated Receptor Downregulation and Viral Replication by Poe, Jerrod A., Smithgall, Thomas E.

“…Nef, a human immunodeficiency virus type 1 (HIV-1) accessory factor capable of interaction with a diverse array of host cell signaling molecules, is essential…”
Get full text

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner by Narute, Purushottam S, Smithgall, Thomas E

“…The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell…”
Get full text

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement by Moroco, Jamie A, Craigo, Jodi K, Iacob, Roxana E, Wales, Thomas E, Engen, John R, Smithgall, Thomas E

“…Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a…”
Get full text

Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population by DE GROH, Eric D, SWANHART, Lisa M, CIANCIOLO COSENTINO, Chiara, JACKSON, Rachel L, WEIXIANG DAI, KITCHENS, Carolyn A, DAY, Billy W, SMITHGALL, Thomas E, HUKRIEDE, Neil A

“…One of the first hallmarks of kidney regeneration is the reactivation of genes normally required during organogenesis. Identification of chemicals with the…”
Get full text

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding by Wu, Mousheng, Alvarado, John J, Augelli-Szafran, Corinne E, Ptak, Roger G, Smithgall, Thomas E

“…The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate…”
Get full text

Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells by Zhang, Xiong, Simerly, Calvin, Hartnett, Carrie, Schatten, Gerald, Smithgall, Thomas E.

“…Embryonic stem (ES) cells are characterized by pluripotency, defined as the developmental potential to generate cell lineages derived from all three primary…”
Get full text