Search Results - "SMITH, Richard W. P"

Poly(A)-binding protein (PABP): a common viral target by Smith, Richard W P, Gray, Nicola K

“…Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we…”
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Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation by Brook, Matthew, Tomlinson, Gareth H., Miles, Katherine, Smith, Richard W. P., Rossi, Adriano G., Hiemstra, Pieter S., van ’t Wout, Emily F. A., Dean, Jonathan L. E., Gray, Nicola K., Lu, Wuyuan, Gray, Mohini

“…Neutrophils are the first and most numerous cells to arrive at the site of an inflammatory insult and are among the first to die. We previously reported that…”
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Direct Stimulation of Translation by the Multifunctional Herpesvirus ICP27 Protein by LARRALDE, Osmany, SMITH, Richard W. P, WILKIE, Gavin S, MALIK, Poonam, GRAY, Nicola K, CLEMENTS, J. Barklie

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Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding by Smith, Richard W. P., Anderson, Ross C., Larralde, Osmany, Smith, Joel W. S., Gorgoni, Barbara, Richardson, William A., Malik, Poonam, Graham, Sheila V., Gray, Nicola K.

“…Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound…”
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Poly(A)-binding proteins are required for diverse biological processes in metazoans by Smith, Richard W P, Blee, Tajekesa K P, Gray, Nicola K

“…PABPs [poly(A)-binding proteins] bind to the poly(A) tail of eukaryotic mRNAs and are conserved in species ranging from yeast to human. The prototypical…”
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DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation by Smith, Richard W P, Anderson, Ross C, Smith, Joel W S, Brook, Matthew, Richardson, William A, Gray, Nicola K

“…DAZ-associated protein 1 (DAZAP1) is an RNA-binding protein required for normal growth, development, and fertility in mice. However, its molecular functions…”
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RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary by Rosario, Roseanne, Smith, Richard W P, Adams, Ian R, Anderson, Richard A

“…Can novel meiotic RNA targets of DAZL (deleted in azoospermia-like) be identified in the human foetal ovary? SYCP1 (synaptonemal complex protein-1), TEX11…”
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Poly(A)-binding proteins and mRNA localization: who rules the roost? by Gray, Nicola K, Hrabálková, Lenka, Scanlon, Jessica P, Smith, Richard W P

“…RNA-binding proteins are often multifunctional, interact with a variety of protein partners and display complex localizations within cells. Mammalian…”
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Coordinated Regulation of Replication Protein A Activities by Its Subunits p14 and p32 by Weisshart, Klaus, Pestryakov, Pavel, Smith, Richard W P, Hartmann, Hella, Kremmer, Elisabeth, Lavrik, Olga, Nasheuer, Heinz-Peter

“…The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive…”
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A Molecular Doorstop Ensures a Trickle through Translational Repression by Brook, Matthew, Smith, Richard W.P., Gray, Nicola K.

“…Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how…”
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Regulation of translation initiation by herpesviruses by Smith, Richard W P, Graham, Sheila V, Gray, Nicola K

“…Viruses are dependent upon the host cell protein synthesis machinery, thus they have developed a range of strategies to manipulate host translation to favour…”
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Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase α‐primase by Smith, Richard W. P., Nasheuer, Heinz‐Peter

“…Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase…”
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Species Specificity of Simian Virus 40 DNA Replication in Vitro Requires Multiple Functions of Human DNA Polymerase Î by Richard W. P. Smith, Claudia Steffen, Frank Grosse, Heinz-Peter Nasheuer

“…Human cell extracts support the replication of SV40 DNA, whereas mouse cell extracts do not. Species specificity is determined at the level of initiation of…”
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Species Specificity of Simian Virus 40 DNA Replication in Vitro Requires Multiple Functions of Human DNA Polymerase α by Smith, Richard W.P., Steffen, Claudia, Grosse, Frank, Nasheuer, Heinz-Peter

“…Human cell extracts support the replication of SV40 DNA, whereas mouse cell extracts do not. Species specificity is determined at the level of initiation of…”
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Multiple Phosphorylation Sites of DNA Polymerase α-Primase Cooperate to Regulate the Initiation of DNA Replication in Vitro by Oliver Schub, Gabor Rohaly, Richard W. P. Smith, Annerose Schneider, Silke Dehde, Irena Dornreiter, Heinz-Peter Nasheuer

“…DNA polymerase α-primase (pol-prim) is the only enzyme that can start DNA replication de novo . The 180-kDa (p180) and 68-kDa (p68) subunits of the human…”
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Primase Activity of Human DNA Polymerase α-Primase by Annerose Schneider, Richard W. P. Smith, Armin R. Kautz, Klaus Weisshart, Frank Grosse, Heinz-Peter Nasheuer

“…DNA polymerase α-primase consists of four subunits, p180, p68, p58, and p48, and comprises two essential enzymatic functions. To study the primase activity of…”
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The coupling between ftsZ transcription and initiation of DNA replication is not mediated by the DnaA-boxes upstream of ftsZ or by DnaA by Smith, R W, McAteer, S, Masters, M

“…The DnaA protein of Escherichia coli is a multi-functional protein which, In addition to promoting initiation of replication, can regulate the initiation or…”
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The influence of the dnaa protein on transcription of the ftsz and dnaa genes in escherichia coli by Smith, Richard W. P

“…The investigation of the mechanisms governing the control of chromosomal DNA synthesis and cell division is fundamental to the understanding of the regulation…”
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Cell division and transcription of ftsZ by SMITH, R. W. P, MASTERS, M, DONACHIE, W. D

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