Search Results - "SMITH, Randy L"

A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis by Benneyworth, Michael A, Xiang, Zixiu, Smith, Randy L, Garcia, Efrain E, Conn, P Jeffrey, Sanders-Bush, Elaine

“…Recent clinical studies reveal that selective agonists of group II metabotropic glutamate (mGlu) receptors have robust efficacy in treating positive and…”
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5-Hydroxytryptamine (serotonin)2A receptors in rat anterior cingulate cortex mediate the discriminative stimulus properties of d-lysergic acid diethylamide by Gresch, Paul J, Barrett, Robert J, Sanders-Bush, Elaine, Smith, Randy L

“…d-Lysergic acid diethylamide (LSD), an indoleamine hallucinogen, produces profound alterations in mood, thought, and perception in humans. The brain site(s)…”
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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity by Rodriguez, Alice L, Grier, Mark D, Jones, Carrie K, Herman, Elizabeth J, Kane, Alexander S, Smith, Randy L, Williams, Richard, Zhou, Ya, Marlo, Joy E, Days, Emily L, Blatt, Tasha N, Jadhav, Satyawan, Menon, Usha N, Vinson, Paige N, Rook, Jerri M, Stauffer, Shaun R, Niswender, Colleen M, Lindsley, Craig W, Weaver, C David, Conn, P Jeffrey

“…Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel treatments for multiple central nervous system (CNS) disorders, including…”
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Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(±)DOI] in C57BL/6J mice by SMITH, Randy L, BARRETT, Robert J, SANDERS-BUSH, Elaine

“…The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted…”
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Discovery of Molecular Switches That Modulate Modes of Metabotropic Glutamate Receptor Subtype 5 (mGlu5) Pharmacology in Vitro and in Vivo within a Series of Functionalized, Regioisomeric 2- and 5-(Phenylethynyl)pyrimidines by Sharma, Sameer, Kedrowski, Jeffrey, Rook, Jerri M, Smith, Randy L, Jones, Carrie K, Rodriguez, Alice L, Conn, P. Jeffrey, Lindsley, Craig W

“…We describe the synthesis and SAR of a series of analogues of the mGlu5 partial antagonist 5-(phenylethynyl)pyrimidine. New molecular switches are identified…”
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Increases in avoidance responding produced by REM sleep deprivation or serotonin depletion are reversed by administration of 5-hydroxytryptophan by Smith, Randy L, Kennedy, Craig H

“…Our objective was to directly compare the effects of rapid eye movement (REM) sleep deprivation (REMSD) and serotonin 5-hydroxytryptamine (5-HT) depletion on…”
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Role of G(q) protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane by Garcia, Efrain E, Smith, Randy L, Sanders-Bush, Elaine

“…Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia. In addition, several studies indicate that…”
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Chronic Phenethylamine Hallucinogen Treatment Alters Behavioral Sensitivity to a Metabotropic Glutamate 2 3 Receptor Agonist by BENNEYWORTH, Michael A, SMITH, Randy L, SANDERS-BUSH, Elaine

“…Recent clinical studies in schizophrenic patients show that a selective agonist of group II metabotropic glutamate (mGlu) receptors has robust efficacy in…”
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Behavioral Tolerance to Lysergic Acid Diethylamide is Associated with Reduced Serotonin-2A Receptor Signaling in Rat Cortex by GRESCH, Paul J, SMITH, Randy L, BARRETT, Robert J, SANDERS-BUSH, Elaine

“…Tolerance is defined as a decrease in responsiveness to a drug after repeated administration. Tolerance to the behavioral effects of hallucinogens occurs in…”
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Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice by Benneyworth, Michael A, Smith, Randy L, Barrett, Robert J, Sanders-Bush, Elaine

“…The drug discrimination procedure is the most frequently used in vivo model of hallucinogen activity. Historically, most drug discrimination studies have been…”
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Possible role for the 5-HT1A receptor in the behavioral effects of REM sleep deprivation on free-operant avoidance responding in rat by HARVEY, Mark T, SMITH, Randy L, MAY, Michael E, CARUSO, Mary, ROBERTS, Celeste, PATTERSON, Tina G, VALDOVINOS, Maria, KENNEDY, Craig H

“…REM sleep deprivation (REMSD) has been shown to increase rates of free-operant avoidance responding. Depletion of 5-hydroxytryptamine (5-HT, serotonin) levels…”
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Evidence for bidirectional cues as a function of time following treatment with amphetamine: implications for understanding tolerance and withdrawal by Barrett, Robert J., Caul, William F., Smith, Randy L.

“…Previous drug-discrimination studies have focused on characterizing the cue properties associated with amphetamine's (AMPH) primary effect. Results from recent…”
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Stimulus generalization by fenfluramine in a quipazine–ketanserin drug discrimination is not dependent on indirect serotonin release by Smith, Randy L., Gresch, Paul J., Barrett, Robert J., Sanders-Bush, Elaine

“…The purpose of this study was to determine if animals trained to discriminate a serotonin 2A (5-HT 2A) receptor agonist from a 5-HT 2A receptor antagonist…”
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Role of Gq protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane by Garcia, Efrain E., Smith, Randy L., Sanders-Bush, Elaine

“…Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia. In addition, several studies indicate that G q…”
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Evolution of Populus nigra (Sect. Aigeiros): Introgressive Hybridization and the Chloroplast Contribution of Populus alba (Sect. Populus) by Smith, Randy L., Sytsma, Kenneth J.

“…Restriction site variation in chloroplast DNA and nuclear ribosomal DNA was examined in 16 accessions from the Salicaceae comprising ten species of Populus and…”
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Role of G q protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane by Garcia, Efrain E., Smith, Randy L., Sanders-Bush, Elaine

“…Extensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia. In addition, several studies indicate that G…”
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Discovery of Molecular Switches that Modulate Modes of mGlu5 Pharmacology In Vitro and In Vivo Within a Series of Functionalized, Regioisomeric 2- and 5-(Phenylethynyl) Pyrimidines by Sharma, Sameer, Kedrowski, Jeffrey, Rook, Jerri M., Smith, Randy L., Jones, Carrie K., Rodriguez, Alice L., Conn, P. Jeffrey, Lindsley, Craig W.

“…This Letter describes the synthesis and SAR of a series of analogs of the mGlu 5 partial antagonist 5-(phenylethynyl)pyrimidine. New molecular switches are…”
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Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57BI/6J mice by BENNEYWORTH, Michael A, SMITH, Randy L, BARRETT, Robert J, SANDERS-BUSH, Elaine

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Hyperinsulinemia in rats with ventromedial hypothalamic lesions: Role of hyperphagia by King, Bruce M, Smith, Randy L, Frohman, Lawrence A

“…Examined the relation of hyperinsulinemia to hyperphagia in 18 female hooded Long-Evans rats with lesions of the ventromedial hypothalamus (VMH). Plasma…”
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Evolution of Populus nigra (Sect. Aigeiros): Introgressive Hybridization and the Chloroplast Contribution of Populus alba (Sect. Populus) by Smith, Randy L., Sytsma, Kenneth J.

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