Search Results - "SMITH, Jacqueline H"

Modeling Collision Avoidance Actions Using Environment-Vulnerability-Decision-Technology Framework by Es Haghi, Sina, Smith, Jacqueline H., Dorrington, Scott, Reid, Jack, Colombo, Camilla, Wood, Danielle

“…The population of Anthropogenic Space Objects (ASOs) in Earth's orbit is steadily increasing. As of the start of 2023, the US Space Surveillance Network is…”
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COMPARATIVE EFFECTS OF PHTHALATE MONOESTERS ON GAP JUNCTIONAL INTERCELLULAR COMMUNICATION AND PEROXISOME PROLIFERATION IN RODENT AND PRIMATE HEPATOCYTES by Kamendulis, Lisa M., Isenberg, Jason S., Smith, Jacqueline H., Jr, George Pugh, Lington, Arthur W., Klaunig, James E.

“…Several phthalate esters, compounds used as plasticizers in a variety of commercial products, have been shown to induce hepatic tumors in rodents. In this…”
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The political and legal landscape of space debris mitigation in emerging space nations by Smith, Jacqueline H., Rathnasabapathy, Minoo, Wood, Danielle

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Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents by ISENBERG, Jason S, KAMENDULIS, Lisa M, ACKLEY, David C, SMITH, Jacqueline H, PUGH, George JR, LINGTON, Arthur W, MCKEE, Richard H, KLAUNIG, James E

“…The tumor promotion stage of chemical carcinogenesis has been shown to exhibit a persistence of cellular effects during treatment and the reversibility of…”
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Ninety-day feeding study in Fischer-344 rats of highly refined petroleum-derived food-grade white oils and waxes by Smith, J H, Mallett, A K, Priston, R A, Brantom, P G, Worrell, N R, Sexsmith, C, Simpson, B J

“…Subchronic 90-day feeding studies were conducted in male and female Fischer-344 (F-344) rats on highly refined white mineral oils and waxes representative of…”
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Comparative 90-day feeding study with low-viscosity white mineral oil in Fischer-344 and Sprague-Dawley-derived CRL:CD rats by Firriolo, J M, Morris, C F, Trimmer, G W, Twitty, L D, Smith, J H, Freeman, J J

“…A 90-day study was conducted to compare the effects of dietary administration of a food-grade white oil in female Fischer-344 (F-344) and…”
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Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice by Smith, J H, Maita, K, Sleight, S D, Hook, J B

“…In mice, only males are susceptible to chloroform (CHCl3) nephrotoxicity and the susceptibility appears to be related to renal mixed function oxidase activity…”
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Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys by PUGH, G. JR, ISENBERG, J. S, KAMENDULIS, L. M, ACKLEY, D. C, CLARE, L. J, BROWN, R, LINGTON, A. W, SMITH, J. H, KLAUNIG, J. E

“…The effects of the peroxisome proliferators di-isononyl phthalate (DINP) and di-2-ethylhexyl phthalate (DEHP) were evaluated in young adult male cynomolgus…”
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Metabolism of the liver carcinogen N-nitrosopyrrolidine by rat liver microsomes by Hecker, L I, Farrelly, J G, Smith, J H, Saavedra, J E, Lyon, P A

“…This report represents a study of the total metabolism of the hepatocellular carcinogen, N-nitrosopyrrolidine (NO-PYR), by rat liver microsomes and…”
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Effects of Di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver by ISENBERG, J. S, KAMENDULIS, L. M, SMITH, J. H, ACKLEY, D. C, PUGH, G. JR, LINGTON, A. W, KLAUNIG, J. E

“…The present study evaluated the effect of di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), peroxisomal beta-oxidation…”
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Comparative in Vivo Hepatic Effects of Di-Isononyl Phthalate (DINP) and Related C7–C11 Dialkyl Phthalates on Gap Junctional Intercellular Communication (GJIC), Peroxisomal Beta-Oxidation (PBOX), and DNA Synthesis in Rat and Mouse Liver by Smith, Jacqueline H., Isenberg, Jason S., Pugh, George, Kamendulis, Lisa M., Ackley, David, Lington, Arthur W., Klaunig, James E.

“…The short-term hepatic effects of DINP (CAS 68515-48-0, designated DINP-1) in rats and mice were evaluated at tumorigenic and nontumorigenic doses from…”
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Mechanism of chloroform nephrotoxicity. III. Renal and hepatic microsomal metabolism of chloroform in mice by Smith, J H, Hook, J B

“…In vitro studies with male ICR mouse renal cortical slices have indicated that chloroform (CHCl3) is metabolized by the kidney to a nephrotoxic intermediate,…”
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Mechanism of chloroform nephrotoxicity. I. Time course of chloroform toxicity in male and female mice by Smith, J H, Maita, K, Sleight, S D, Hook, J B

“…Chloroform (CHCl3) nephrotoxicity in male mice could be detected as early as 2 hr after CHCl3 administration (250 microliter/kg, sc) as decreased ability of…”
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Chemically induced nephrotoxicity: role of metabolic activation by Rush, G F, Smith, J H, Newton, J F, Hook, J B

“…Renal xenobiotic metabolism can result in production of electrophiles or free radicals that may covalently bind macromolecules or initiate lipid peroxidation…”
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Mechanism of chloroform nephrotoxicity. II. In vitro evidence for renal metabolism of chloroform in mice by Smith, J H, Hook, J B

“…Preincubation of renal cortical slices with chloroform (CHCl3) from male, but not female, mice resulted in a subsequent decrease of the ability of the slices…”
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Renal Ultrastructural and Biochemical Injuries Induced by Aminoglycosides by Cojocel, Constantin, Docius, N., Maita, Keizo, Smith, Jacqueline H., Hook, Jerry B.

“…Aminoglycoside-induced proteinuria may result from general renal damage or may reflect alterations in specific steps in the renal handling of proteins. To…”
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Role of intrarenal biotransformation in chloroform-induced nephrotoxicity in rats by Smith, J H, Hewitt, W R, Hook, J B

“…Various ketonic agents potentiate the hepatic and renal toxicity of halogenated solvents in mice and rats. Characteristics of CHCl3 nephrotoxicity and of…”
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Nephrotoxicity of chloroform: metabolism to phosgene by the mouse kidney by Branchflower, R V, Nunn, D S, Highet, R J, Smith, J H, Hook, J B, Pohl, L R

“…In this investigation, we have attempted to determine whether chloroform (CHCl3)-induced nephrotoxicity might be due to its metabolism to phosgene (COCl2) in…”
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Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys by Bailie, M B, Smith, J H, Newton, J F, Hook, J B

“…Metabolism of chloroform (CHCl3) by a cytochrome P-450-dependent process to a reactive metabolite may be required to elicit hepatic and renal toxicities…”
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Sensitivity of urinary enzymes as indicators of renal toxicity of the anticancer drug cis-platin by Litterst, C, Smith, J H, Smith, M A, Uozumi, J, Copley, M

“…Rats were intravenously injected with cis-platin in order to evaluate the sensitivity of noninvasive means of detecting renal toxicity. Doses of 8 mg/kg and 2…”
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