Search Results - "SMITH, G. C"

Metabolic exhaustion in infection, cancer and autoimmunity by McKinney, E. F., Smith, K. G. C.

“…It has become increasingly clear that changes in metabolism are not just consequences of T cell activation but instead are also essential drivers of that…”
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Experimental Realization of a Quantum Dot Energy Harvester by Jaliel, G., Puddy, R. K., Sánchez, R., Jordan, A. N., Sothmann, B., Farrer, I., Griffiths, J. P., Ritchie, D. A., Smith, C. G.

“…We demonstrate experimentally an autonomous nanoscale energy harvester that utilizes the physics of resonant tunneling quantum dots. Gate-defined quantum dots…”
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Competence and competition: the challenge of becoming a long-lived plasma cell by Hiepe, Falk, Inamine, Ayako, Radbruch, Andreas, Luger, Elke O, Smith, Kenneth G. C, Dörner, Thomas, Muehlinghaus, Gwendolin

“…Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-lived end-stage products of B-cell differentiation that deserve…”
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Charge and Spin State Readout of a Double Quantum Dot Coupled to a Resonator by Petersson, K. D, Smith, C. G, Anderson, D, Atkinson, P, Jones, G. A. C, Ritchie, D. A

“…State readout is a key requirement for a quantum computer. For semiconductor-based qubit devices it is usually accomplished using a separate mesoscopic…”
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Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitis by Smith, Rona M., Jones, Rachel B., Guerry, Mary-Jane, Laurino, Simona, Catapano, Fausta, Chaudhry, Afzal, Smith, Kenneth G. C., Jayne, David R. W.

“…Objective Rituximab is effective induction therapy in refractory or relapsing antineutrophil cytoplasmic antibody–associated vasculitis (AAV). However, further…”
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Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia by Fernandez-Egea, Emilio, Vértes, Petra E, Flint, Shaun M, Turner, Lorinda, Mustafa, Syed, Hatton, Alex, Smith, Kenneth G C, Lyons, Paul A, Bullmore, Edward T

“…Hypothetically, psychotic disorders could be caused or conditioned by immunological mechanisms. If so, one might expect there to be peripheral immune system…”
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Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease by Peters, James E, Lyons, Paul A, Lee, James C, Richard, Arianne C, Fortune, Mary D, Newcombe, Paul J, Richardson, Sylvia, Smith, Kenneth G C

“…Genome-wide association studies (GWAS) have transformed our understanding of the genetics of complex traits such as autoimmune diseases, but how risk variants…”
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Long term outcomes of patients with tuberculous meningitis: The impact of drug resistance by Evans, Emily E, Avaliani, Teona, Gujabidze, Mariam, Bakuradze, Tinatin, Kipiani, Maia, Sabanadze, Shorena, Smith, Alison G. C, Avaliani, Zaza, Collins, Jeffrey M, Kempker, Russell R

“…Background Little is known about the impact of drug-resistance on clinical outcomes among patients with tuberculosis meningitis (TBM). Methods A retrospective…”
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Risk stratification for early-onset fetal growth restriction in women with abnormal serum biomarkers: a retrospective cohort study by Ormesher, L., Warrander, L., Liu, Y., Thomas, S., Simcox, L., Smith, G. C. S., Myers, J. E., Johnstone, E. D.

“…Abnormal maternal serum biomarkers (AMSB), identified through the aneuploidy screening programme, are frequent incidental findings in pregnancy. They are…”
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Efficient inhibition of miR-155 function in vivo by peptide nucleic acids by Fabani, Martin M, Abreu-Goodger, Cei, Williams, Donna, Lyons, Paul A, Torres, Adrian G, Smith, Kenneth G.C, Enright, Anton J, Gait, Michael J, Vigorito, Elena

“…MicroRNAs (miRNAs) play an important role in diverse physiological processes and are potential therapeutic agents. Synthetic oligonucleotides (ONs) of…”
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Assessing the risks of SARS-CoV-2 in wildlife by Delahay, R J, de la Fuente, J, Smith, G C, Sharun, K, Snary, E L, Flores Girón, L, Nziza, J, Fooks, A R, Brookes, S M, Lean, F Z X, Breed, A C, Gortazar, C

“…The novel coronavirus SARS-CoV-2 likely emerged from a wildlife source with transmission to humans followed by rapid geographic spread throughout the globe and…”
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Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease by Richard, Arianne C, Peters, James E, Savinykh, Natalia, Lee, James C, Hawley, Eric T, Meylan, Françoise, Siegel, Richard M, Lyons, Paul A, Smith, Kenneth G C

“…Chronic inflammation in inflammatory bowel disease (IBD) results from a breakdown of intestinal immune homeostasis and compromise of the intestinal barrier…”
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Fast High-Fidelity Single-Shot Readout of Spins in Silicon Using a Single-Electron Box by Oakes, G. A., Ciriano-Tejel, V. N., Wise, D. F., Fogarty, M. A., Lundberg, T., Lainé, C., Schaal, S., Martins, F., Ibberson, D. J., Hutin, L., Bertrand, B., Stelmashenko, N., Robinson, J. W. A., Ibberson, L., Hashim, A., Siddiqi, I., Lee, A., Vinet, M., Smith, C. G., Morton, J. J. L., Gonzalez-Zalba, M. F.

“…Three key metrics for readout systems in quantum processors are measurement speed, fidelity, and footprint. Fast high-fidelity readout enables midcircuit…”
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Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer by Patel, K. M., van der Vos, K. E., Smith, C. G., Mouliere, F., Tsui, D., Morris, J., Chandrananda, D., Marass, F., van den Broek, D., Neal, D. E., Gnanapragasam, V. J., Forshew, T., van Rhijn, B. W., Massie, C. E., Rosenfeld, N., van der Heijden, M. S.

“…Muscle Invasive Bladder Cancer (MIBC) has a poor prognosis. Whilst patients can achieve a 6% improvement in overall survival with Neo-Adjuvant Chemotherapy…”
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Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus by Catapano, Fausta, Chaudhry, Afzal N., Jones, Rachel B., Smith, Kenneth G.C., Jayne, David W.

“…Background. Systemic lupus erythematosus is a relapsing autoimmune disease. Conventional therapy increases the risk of infection and malignancies; furthermore,…”
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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes by FERREIRA, Ricardo C, HUI GUO, LYONS, Paul A, SMITH, Kenneth G. C, ACHENBACH, Peter, BEYERLEIN, Andreas, DUNGER, David B, CLAYTON, David G, WICKER, Linda S, TODD, John A, BONIFACIO, Ezio, WALLACE, Chris, COULSON, Richard M. R, ZIEGLER, Anette-G, SMYTH, Deborah J, PEKALSKI, Marcin L, BURREN, Oliver S, CUTLER, Antony J, DOECKE, James D, FLINT, Shaun, MCKINNEY, Eoin F

“…Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost…”
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Next steps to prevent stillbirth associated with growth restriction by Kingdom, JC, Smith, GC

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Gigahertz quantized charge pumping in graphene quantum dots by Connolly, M. R., Chiu, K. L., Giblin, S. P., Kataoka, M., Fletcher, J. D., Chua, C., Griffiths, J. P., Jones, G. A. C., Fal'ko, V. I., Smith, C. G., Janssen, T. J. B. M.

“…Single-electron pumps are set to revolutionize electrical metrology by enabling the ampere to be redefined in terms of the elementary charge of an electron 1 …”
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Cervical length and obstetric history predict spontaneous preterm birth: development and validation of a model to provide individualized risk assessment by Celik, E., To, M., Gajewska, K., Smith, G. C. S., Nicolaides, K. H.

“…Objectives To evaluate the ability of combinations of cervical length and maternal history to assess the risk of spontaneous preterm birth, and to provide a…”
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A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance by TANNER, M. A, GALANELLO, R, PENNELL, D. J, DESSI, C, SMITH, G. C, WESTWOOD, M. A, AGUS, A, ROUGHTON, M, ASSOMULL, R, NAIR, S. V, WALKER, J. M

“…Cardiac complications secondary to iron overload are the leading cause of death in beta-thalassemia major. Approximately two thirds of patients maintained on…”
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