Search Results - "SMITH, Darin"

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling by Haling, Jacob R., Sudhamsu, Jawahar, Yen, Ivana, Sideris, Steve, Sandoval, Wendy, Phung, Wilson, Bravo, Brandon J., Giannetti, Anthony M., Peck, Ariana, Masselot, Alexandre, Morales, Tony, Smith, Darin, Brandhuber, Barbara J., Hymowitz, Sarah G., Malek, Shiva

“…Numerous oncogenic mutations occur within the BRAF kinase domain (BRAFKD). Here we show that stable BRAF-MEK1 complexes are enriched in BRAFWT and KRAS mutant…”
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Hematopoietic properties of granulocyte colony-stimulating factor/immunoglobulin (G-CSF/IgG-Fc) fusion proteins in normal and neutropenic rodents by Cox, George N, Chlipala, Elizabeth A, Smith, Darin J, Carlson, Sharon J, Bell, Stacie J, Doherty, Daniel H

“…Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino…”
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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor by YEH, Tammie C, MARSH, Vivienne, MARLOW, Allison, HURLEY, Brian, LYSSIKATOS, Joe, LEE, Patrice A, WINKLER, James D, KOCH, Kevin, WALLACE, Eli, BERNAT, Bryan A, BALLARD, Josh, COLWELL, Heidi, EVANS, Ron J, PARRY, Janet, SMITH, Darin, BRANDHUBER, Barbara J, GROSS, Stefan

“…Purpose: The Ras-Raf-mitogen-activated protein kinase kinase (MEK) pathway is overactive in many human cancers and is thus a target for novel therapeutics. We…”
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Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer by Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A

“…Capping off an era marred by drug development failures and punctuated by waning interest and presumed intractability toward direct targeting of KRAS, new…”
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Emotion and motivated behavior: postural adjustments to affective picture viewing by Hillman, Charles H, Rosengren, Karl S, Smith, Darin P

“…Thirty-six participants (18 female, 18 male) viewed affective pictures to investigate the coupling between emotional reactions and motivated behavior. Framed…”
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A cross-sectional examination of age and physical activity on performance and event-related brain potentials in a task switching paradigm by Hillman, Charles H., Kramer, Arthur F., Belopolsky, Artem V., Smith, Darin P.

“…Younger and older physically active and sedentary adults participated in a task switching paradigm in which they performed a task repeatedly or switched…”
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A Long-Acting, Mono-PEGylated Human Growth Hormone Analog Is a Potent Stimulator of Weight Gain and Bone Growth in Hypophysectomized Rats by Cox, George N, Rosendahl, Mary S, Chlipala, Elizabeth A, Smith, Darin J, Carlson, Sharon J, Doherty, Daniel H

“…Recombinant human GH is used to treat GH deficiency in children and adults and wasting in AIDS patients. GH has a circulating half-life of only a few hours in…”
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A Long-Acting, Highly Potent Interferon α-2 Conjugate Created Using Site-Specific PEGylation by Rosendahl, Mary S, Doherty, Daniel H, Smith, Darin J, Carlson, Sharon J, Chlipala, Elizabeth A, Cox, George N

“…Recombinant interferon α-2 (IFN-α2) is used clinically to treat a variety of viral diseases and cancers. IFN-α2 has a short circulating half-life, which…”
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Influences of Age on Emotional Reactivity During Picture Processing by Smith, Darin P., Hillman, Charles H., Duley, Aaron R.

“…We compared emotional reactivity to affective pictures for 32 older (60–71 years) and 34 younger (18–23 years) adults. We collected the startle-blink reflex,…”
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Site-Specific PEGylation of Engineered Cysteine Analogues of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor by Doherty, Daniel H, Rosendahl, Mary S, Smith, Darin J, Hughes, Jennifer M, Chlipala, Elizabeth A, Cox, George N

“…Granulocyte macrophage colony-stimulating factor (GM-CSF) stimulates proliferation of hematopoietic cells of the macrophage and granulocyte lineages and is…”
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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer by Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A

“…Capping off an era marred by drug development failures and punctuated by waning interest and presumed intractability toward direct targeting of KRAS, new…”
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Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity by Long, Dana L., Doherty, Daniel H., Eisenberg, Stephen P., Smith, Darin J., Rosendahl, Mary S., Christensen, Kurt R., Edwards, Dean P., Chlipala, Elizabeth A., Cox, George N.

“…Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used…”
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Cervical spinal motion during intubation : efficacy of stabilization maneuvers in the setting of complete segmental instability by LENNARSON, Peter J, SMITH, Darin W, SAWIN, Paul D, TODD, Michael M, SATO, Yutaka, TRAYNELIS, Vincent C

“…The purpose of this study was to characterize and compare segmental cervical motion during orotracheal intubation in cadavers with and without a complete…”
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Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein by Cox, George N, Smith, Darin J, Carlson, Sharon J, Bendele, Alison M, Chlipala, Elizabeth A, Doherty, Daniel H

“…The aim of this study was to determine whether fusion proteins comprising human granulocyte colony-stimulating factor (G-CSF) joined to human immunoglobulin G1…”
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Low-Titer O-Positive Whole Blood: Lessons From the Battlefield for Civilian Rural Hospitals by O'Hollearn, Sean, Schaefer, Randall, DuBose, Cassandra, Smith, Darin, Goforth, Carl

“…Low-titer O-positive whole blood was used extensively by the military during operations in Iraq and Afghanistan. Studies have consistently shown that this…”
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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2 by Pegram, Laurel M., Liddle, Jennifer C., Xiao, Yao, Hoh, Maria, Rudolph, Johannes, Iverson, Dylan B., Vigers, Guy P., Smith, Darin, Zhang, Hailong, Wang, Weiru, Moffat, John G., Ahn, Natalie G.

“…Conformational selection by small molecules expands inhibitory possibilities for protein kinases. Nuclear magnetic resonance (NMR) measurements of the…”
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Building H.O.U.S.E (Healthy Outcomes Using a Supportive Environment): Exploring the Role of Affordable and Inclusive Housing for LGBTQIA+ Older Adults by Rosenwohl-Mack, Amy, Smith, Darin, Greene, Meredith, Skultety, Karyn, Deutsch, Madeline, Dubbin, Leslie, Flatt, Jason D

“…Little is known about how permanent, inclusive, affordable, and supportive long-term housing may affect the health of low-income lesbian, gay, bisexual,…”
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Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species by Hunt, Kevin W, Cook, Adam W, Watts, Ryan J, Clark, Christopher T, Vigers, Guy, Smith, Darin, Metcalf, Andrew T, Gunawardana, Indrani W, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Thomas, Allen A, Rana, Sumeet, Kallan, Nicholas C, DeLisle, Robert K, Rizzi, James P, Regal, Kelly, Sammond, Douglas, Groneberg, Robert, Siu, Michael, Purkey, Hans, Lyssikatos, Joseph P, Marlow, Allison, Liu, Xingrong, Tang, Tony P

“…A hallmark of Alzheimer’s disease is the brain deposition of amyloid beta (Aβ), a peptide of 36–43 amino acids that is likely a primary driver of…”
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Hematopoietic Properties of Granulocyte Colony-Stimulating Factor/Immunoglobulin by Cox, George N, Chlipala, Elizabeth A, Smith, Darin J, Carlson, Sharon J, Bell, Stacie J, Doherty, Daniel H

“…Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino…”
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Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System by Thomas, Allen A, Hunt, Kevin W, Volgraf, Matthew, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Sammond, Douglas, Tang, Tony P, Rhodes, Susan P, Metcalf, Andrew T, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Do, Mary K. Geck, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P, Gunawardana, Indrani W

“…In an attempt to increase selectivity vs Cathepsin D (CatD) in our BACE1 program, a series of 1,3,4,4a,10,10a-hexahydropyrano[4,3-b]chromene analogues was…”
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