Search Results - "SMITH, Carr J"

Influences of Age, Gender, Smoking, and Family History on Autoimmune Thyroid Disease Phenotype by Manji, N., Carr-Smith, J. D., Boelaert, K., Allahabadia, A., Armitage, M., Chatterjee, V. K., Lazarus, J. H., Pearce, S. H. S., Vaidya, B., Gough, S. C., Franklyn, J. A.

“…Context: Both genetic and environmental factors contribute to susceptibility to Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), as well as disease…”
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Predicting the bioconcentration factor of highly hydrophobic organic chemicals by Garg, Rajni, Smith, Carr J.

“…[Display omitted] •Bioconcentration factor (BCF) represents bioaccumulation potential of a chemical.•A new QSAR model is developed to predict the BCF of highly…”
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Epidemiology studies on effects of lithium salts in pregnancy are confounded by the inability to control for other potentially teratogenic factors by Smith, Carr J, Payne, Victoria M

“…In bipolar women who took lithium during pregnancy, several epidemiology studies have reported small increases in a rare fetal cardiac defect termed Ebstein's…”
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Apolipoprotein ɛ4-Associated Protection Against Pediatric Enteric Infections Is a Survival Advantage in Pre-Industrial Populations by Smith, Carr J, Ashford, J Wesson

“…Until 300,000 years ago, ancestors of modern humans ubiquitously carried the apolipoprotein E (APOE) ɛ4/ɛ4 genotype, when the ɛ3 allele mutated from the…”
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Obesity as a Source of Endogenous Compounds Associated With Chronic Disease: A Review by Smith, Carr J, Perfetti, Thomas A, Hayes, A Wallace, Berry, Sir Colin

“…Abstract In 2014, it was estimated that more than 1.9 billion adults were overweight with over 600 million classifiable as obese. Approximately two-thirds of…”
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Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease by Zeitlin, A A, Heward, J M, Newby, P R, Carr-Smith, J D, Franklyn, J A, Gough, S C L, Simmonds, M J

“…Graves’ disease (GD) and Hashimoto's thyroiditis (HT) represent the commonest forms of autoimmune thyroid disease (AITD) each presenting with distinct clinical…”
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Letter to the editors regarding Heringa et al. (2020) by Smith, Carr J., Perfetti, Thomas A.

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Risk factors for glioblastoma are shared by other brain tumor types by Smith, Carr J, Perfetti, Thomas A, Chokshi, Chirayu, Venugopal, Chitra, Ashford, J Wesson, Singh, Sheila K

“…The reported risk factors for glioblastoma (GBM), i.e., ionizing radiation, Li-Fraumeni syndrome, Neurofibromatosis I, and Turcot syndrome, also increase the…”
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Alkylating agents are possible inducers of glioblastoma and other brain tumors by Smith, Carr J, Perfetti, Thomas A, Chokshi, Chirayu, Venugopal, Chitra, Ashford, J Wesson, Singh, Sheila K

“…Epidemiological evidence of an association between exposure to chemical carcinogens and an increased risk for development of glioblastoma (GBM) is limited to…”
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Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer's Disease, and Alzheimer's Prevention by Oriá, Reinaldo B, Smith, Carr J, Ashford, J Wesson, Vitek, Michael P, Guerrant, Richard L

“…Fortea et al.'s. (2024) recent data analysis elegantly calls attention to familial late-onset Alzheimer's disease (AD) with APOE4 homozygosity. The article by…”
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Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository by Tait, K. F., Marshall, T., Berman, J., Carr-Smith, J., Rowe, B., Todd, J. A., Bain, S. C., Barnett, A. H., Gough, S. C. L.

“…Aims  Autoimmune disorders co‐exist in the same individuals and in families, implying a shared aetiology. The aim of this study was to compare the prevalence…”
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Clinical epidemiology studies on potential effects of endocrine disrupting chemicals (EDCs) should exclude subjects with obesity as determined by BMI by Smith, Carr J., Perfetti, Thomas A., Hayes, A. Wallace, Berry, Sir Colin

“…Obesity as determined by BMI is a confounder in clinical evaluations of the effects of endocrine disrupting chemicals (EDCs). Validated regulatory tests are…”
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MMR Vaccination: A Potential Strategy to Reduce Severity and Mortality of COVID-19 Illness by Ashford, J. Wesson, Gold, Jeffrey E., Huenergardt, MaryJane A., Katz, Ronit B.A., Strand, Susanne E., Bolanos, Joe, Wheeler, Christopher J., Perry, George, Smith, Carr J., Steinman, Lawrence, Chen, Mike Y., Wang, Jeffrey C., Ashford, Clinton B., Roth, Walton T., Cheng, Jauhtai Joseph, Chao, Steven, Jennings, Jennifer, Sipple, Daniel, Yamamoto, Vicky, Kateb, Babak, Earnest, David L.

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Bruce Nathan Ames - Paradigm shifts inside the cancer research revolution by Smith, Carr J., Perfetti, Thomas A., Berry, Sir Colin, Brash, Douglas E., Bus, James, Calabrese, Edward, Clemens, Roger A., Fowle, John R. Jack, Greim, Helmut, MacGregor, James T., Maronpot, Robert, Pressman, Peter, Zeiger, Errol, Hayes, A. Wallace

“…•This article is a tribute to Bruce Nathan Ames by fourteen scholars who are particularly familiar with the work of Dr. Ames.•The article highlights the…”
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Categorizing the characteristics of human carcinogens: a need for specificity by Smith, Carr J., Perfetti, Thomas A., Hayes, A. Wallace, Berry, Sir Colin, Trosko, James E., King, Judy A., Goodman, Jay I., Begley, C. Glenn, Dayan, Anthony

“…The International Agency for Research on Cancer (IARC) has recently proposed employing “ten key characteristics of human carcinogens” (TKCs) to determine the…”
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Systemic inflammation and fatal versus non-fatal coronary events by Smith, Carr J

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Perspectives on Pulmonary Inflammation and Lung Cancer Risk in Cigarette Smokers by Smith, Carr J., Perfetti, Thomas A., King, Judy A.

“…Cigarette mainstream smoke (MSS) inhaled by smokers is a complex aerosol composed of minute liquid droplets suspended within a mixture of combustion gases (CO,…”
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Contribution of Single Nucleotide Polymorphisms within FCRL3 and MAP3K7IP2 to the Pathogenesis of Graves’ Disease by Simmonds, M. J., Heward, J. M., Carr-Smith, J., Foxall, H., Franklyn, J. A., Gough, S. C. L.

“…Context: Recently six DNA variants, two of which (M55V and 001Msp) are present in nuclear factor-κB inhibitors SUMO-4 and MAP3K7IP2 and four of which (fcrl3_3,…”
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Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction by Smith, Carr J, Fischer, Thomas H

“…On pharmacological and compositional grounds, cigarette mainstream smoke (MS) aerosol can be broadly categorized as consisting of the following constituents:…”
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Two Obese Patients with Presumptive Diagnosis of Anaphylactoid Syndrome of Pregnancy Presenting at a Community Hospital by Kradel, Brian K, Hinson, Scarlett B, Smith, Carr J

“…Anaphylactoid syndrome of pregnancy (ASP) is a rare but extremely serious complication, with an estimated incidence in North America of 1 in 15 200 deliveries…”
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