Search Results - "SMITH, CLARK W."

Small Molecule Peptidomimetics Containing a Novel Phosphotyrosine Bioisostere Inhibit Protein Tyrosine Phosphatase 1B and Augment Insulin Action by Bleasdale, John E, Ogg, Derek, Palazuk, Barbara J, Jacob, Cynthia S, Swanson, Michael L, Wang, Xin-Yuan, Thompson, David P, Conradi, Robert A, Mathews, W. Rodney, Laborde, Alice L, Stuchly, Christopher W, Heijbel, Anna, Bergdahl, Katrin, Bannow, Carol A, Smith, Clark W, Svensson, Carina, Liljebris, Charlotta, Schostarez, Heinrich J, May, Paul D, Stevens, F. Craig, Larsen, Scott D

“…Protein tyrosine phosphatase 1B (PTP1B) attenuates insulin signaling by catalyzing dephosphorylation of insulin receptors (IR) and is an attractive target of…”
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Employing a superior BACE1 cleavage sequence to probe cellular APP processing by Tomasselli, Alfredo G., Qahwash, Isam, Emmons, Thomas L., Lu, Yifeng, Leone, Joseph W., Lull, June M., Fok, Kam F., Bannow, Carol A., Smith, Clark W., Bienkowski, Michael J., Heinrikson, Robert L., Yan, Riqiang

“…The involvement of β‐secretase (BACE1; β‐site APP‐cleaving enzyme) in producing the β‐amyloid component of plaques found in the brains of Alzheimer's patients,…”
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Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer by Fairbanks, Michael B., Mildner, Ana M., Leone, Joseph W., Cavey, Gregory S., Mathews, W. Rodney, Drong, Roger F., Slightom, Jerry L., Bienkowski, Michael J., Smith, Clark W., Bannow, Carol A., Heinrikson, Robert L.

“…Human platelet heparanase has been purified to homogeneity and shown to consist of two, non-covalently associated polypeptide chains of molecular masses 50 and…”
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A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis by Maggiora, Linda L, Smith, Clark W, Zhang, Zhong Yin

“…A general scheme for obtaining a fluorescent donor/acceptor peptide substrate via solid-phase synthesis methodology is presented. The key feature of this…”
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General procedure for the synthesis of mono-N-acylated 1,6-diaminohexanes by Stahl, Glenn L, Walter, Roderich, Smith, Clark W

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Preparation and characterization of beaded poly(N-acrylylpyrrolidine): bidirectional synthesis of Cys-, His-, Gln-, or Glu-containing polypeptides by Stahl, Glenn L, Walter, Roderich, Smith, Clark W

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Synthesis and some pharmacological properties of [3-.beta.-(2-thienyl)-L-alanine]-8-lysine-vasopressin by Smith, Clark W, Ferger, Martha F, Chan, W. Y

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Isolation and characterization of native human renin derived from Chinese hamster ovary cells by Poorman, R A, Palermo, D P, Post, L E, Murakami, K, Kinner, J H, Smith, C W, Reardon, I, Heinrikson, R L

“…Transfection of Chinese hamster ovary (CHO) cells with a plasmid containing the cDNA for human preprorenin has provided cell lines that secrete 15 mg of native…”
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Primary amide hydrogen exchange in model amino acids: asparagine, glutamine, and glycine amides by Krishna, N. Rama, Sarathy, K. Partha, Huang, Dee Hua, Stephens, Richard L, Glickson, Jerry D, Smith, Clark W, Walter, Roderich

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[5-(N4,N4-Dimethylasparagine),8-lysine]vasopressin: the first 5-position neurohypophyseal hormone analog to retain significant antidiuretic potency by Smith, Clark W, Walter, Roderich, Stavropoulos, George, Theodoropoulos, Dimitrios

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Synthesis and renin inhibitory activity of angiotensinogen analogs having dehydrostatine, Lue.psi.[CH2S]Val, or Lue.psi.[CH2SO] Val at the Pt, P1' cleavage site by Smith, Clark W, Saneii, Hossain H, Sawyer, Tomi K, Pals, Donald T, Scahill, Terrence A, Kamdar, Bharat V, Lawson, Judy A

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A Conformationally Constrained Vasopressin Analog with Antidiuretic Antagonistic Activity by Skala, Gerald, Smith, Clark W., Taylor, Catherine J., Ludens, James H.

“…Application of information derived from a three-dimensional model of vasopressin bound to its antidiuretic receptor resulted in the design and synthesis of a…”
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Synthesis and some pharmacological properties of five analogs of oxytocin having L-homocysteine in position 6 by Smith, Clark W, Ferger, Martha F

“…Five analogs of oxytocin have been synthesized with a homocysteine residue in position 6 and 2-, 3-, or 4-carbon residues in position 1. The compounds, which…”
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Pharmacological effects of introducing a double bond into a binding site of oxytocin. Analogs with L-3,4-dehydroproline in position 7 by Moore, Stanley, Felix, Arthur M, Meienhofer, Johannes, Smith, Clark W, Walter, Roderich

“…The side chain of the proline residue in position 7 of oxytocin has been proposed as a binding site of the hormone for the uterotonic receptor. This is the…”
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Active site studies of neurohypophyseal hormones. Comparison of oxytocin and arginine vasopressin analogs containing 2-D-tyrosine by Hruby, Victor J, Upson, Donald A, Yamamoto, Diane M, Smith, Clark W, Walter, Roderich

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Synthesis and some pharmacological properties of [4-.beta.-(2-thienyl)-L-alanine]oxytocin by Smith, Clark W, Skala, Gerald, Walter, Roderich

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An entirely beaded poly(dimethylacrylamide) support for peptide synthesis by Stahl, Glenn L, Smith, Clark W, Walter, Roderich

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[5-Aspartic acid]-oxytocin: first 5-position neurohypophyseal hormone analog possessing significant biological activity by Walter, Roderich, Skala, Gerald, Smith, Clark W

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Oxytocin analogues with combined high smooth muscle and negligible antidiuretic activities. Investigation of position 7 in neurohypophyseal hormones by Walter, Roderich, Smith, Clark W, Roy, J, Formento, Alice

“…The proline residue in position 7 of oxytocin occupies one of the four corner positions in the two beta turns proposed for the preferred conformation of the…”
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Synthesis and biological activities of arginine-vasopressin analogs designed from a conformation-activity approach by Botos, Christopher R, Smith, Clark W, Chan, Yun-Lai, Walter, Roderich

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