Search Results - "SMIT, Johan W"

Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study by Younes, Anas, Prof, Thieblemont, Catherine, Prof, Morschhauser, Franck, Prof, Flinn, Ian, MD, Friedberg, Jonathan W, Prof, Amorim, Sandy, MD, Hivert, Benedicte, MD, Westin, Jason, MD, Vermeulen, Jessica, MD, Bandyopadhyay, Nibedita, PhD, de Vries, Ronald, MSc, Balasubramanian, Sriram, PhD, Hellemans, Peter, MD, Smit, Johan W, PhD, Fourneau, Nele, Oki, Yasuhiro, MD

“…Summary Background Present first-line therapy for diffuse large B-cell lymphoma, a subtype of non-Hodgkin lymphoma, is rituximab, cyclophosphamide,…”
Get full text

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism by van Herwaarden, Antonius E, Wagenaar, Els, van der Kruijssen, Cornelia M M, van Waterschoot, Robert A B, Smit, Johan W, Song, Ji-Ying, van der Valk, Martin A, van Tellingen, Olaf, van der Hoorn, José W A, Rosing, Hilde, Beijnen, Jos H, Schinkel, Alfred H

“…Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed…”
Get full text

Comparative pharmacokinetics and bioavailability of tapentadol following oral administration of immediate- and prolonged-release formulations by GÖHLER, Karin, BRETT, Martin, SMIT, Johan W, RENGELSHAUSEN, Jens, TERLINDEN, Rolf

“…To evaluate the bioavailability and pharmacokinetics of orally administered tapentadol immediate release (IR) compared with tapentadol prolonged release (PR)…”
Get full text

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors by Tabernero, Josep, Bahleda, Rastislav, Dienstmann, Rodrigo, Infante, Jeffrey R, Mita, Alain, Italiano, Antoine, Calvo, Emiliano, Moreno, Victor, Adamo, Barbara, Gazzah, Anas, Zhong, Bob, Platero, Suso J, Smit, Johan W, Stuyckens, Kim, Chatterjee-Kishore, Moitreyee, Rodon, Jordi, Peddareddigari, Vijay, Luo, Feng R, Soria, Jean-Charles

“…JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor. This first-in-human study evaluates the safety,…”
Get full text

Stable isotope‐labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults by Vries, Ronald, Smit, Johan W., Hellemans, Peter, Jiao, James, Murphy, Joseph, Skee, Donna, Snoeys, Jan, Sukbuntherng, Juthamas, Vliegen, Maarten, Zwart, Loeckie, Mannaert, Erik, Jong, Jan

“…Aims Ibrutinib, an inhibitor of Bruton's tyrosine kinase, is used in the treatment of mantle cell lymphoma or chronic lymphocytic leukaemia. Ibrutinib…”
Get full text

A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors by VENUGOPAL, Balaji, BAIRD, Richard, SMIT, Johan W, FORSLUND, Ann, PHELPS, Charles, CAMM, John, EVANS, T. R. Jeffry, DE BONO, Johann S, BANERJI, Udai, KRISTELEIT, Rebecca S, PLUMMER, Ruth, COWAN, Richard, STEWART, Adam, FOURNEAU, Nele, HELLEMANS, Peter, ELSAYED, Yusri, MCCLUE, Steve

“…To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetic and pharmacodynamic profile of quisinostat, a novel…”
Get full text

Abiraterone Acetate to Lower Androgens in Women With Classic 21-Hydroxylase Deficiency by Auchus, Richard J, Buschur, Elizabeth O, Chang, Alice Y, Hammer, Gary D, Ramm, Carole, Madrigal, David, Wang, George, Gonzalez, Martha, Xu, Xu Steven, Smit, Johan W, Jiao, James, Yu, Margaret K

“…Context: Chronic supraphysiological glucocorticoid therapy controls the androgen excess of 21-hydroxylase deficiency (21OHD) but contributes to the high…”
Get full text

MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4 by VAN HERWAARDEN, Antonius E, SMIT, Johan W, SPARIDANS, Rolf W, WAGENAAR, Els, VAN DER KRUUSSEN, Cornelia M. M, SCHELLENS, Jan H. M, BEIJNEN, Jos H, SCHINKEL, Alfred H

“…Cytochrome P450 3A4 (CYP3A4) is a major determinant of the metabolism of many drugs, including important anticancer drugs, with sometimes profound impact on…”
Get full text

Pharmacokinetic evaluation of tapentadol extended-release tablets in healthy subjects by Zannikos, Peter N, Smit, Johan W, Stahlberg, Hans-Jürgen, Wenge, Birger, Hillewaert, Vera M, Etropolski, Mila S

“…To evaluate serum pharmacokinetics of tapentadol administered to healthy subjects as extended-release (ER) tablets. Seven single-dose studies (five randomized,…”
Get more information

Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir by Huisman, Maarten T, Smit, Johan W, Wiltshire, Hugh R, Beijnen, Jos H, Schinkel, Alfred H

“…Using a mouse model, we tested the effects of in vivo P-glycoprotein inhibition to enhance the oral uptake and penetration into pharmacological sanctuary sites…”
Get more information

In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity by Monbaliu, Johan, Gonzalez, Martha, Bernard, Apexa, Jiao, James, Sensenhauser, Carlo, Snoeys, Jan, Stieltjes, Hans, Wynant, Inneke, Smit, Johan W, Chien, Caly

“…Abiraterone acetate, the prodrug of the cytochrome P450 C17 inhibitor abiraterone, plus prednisone is approved for treatment of metastatic castration-resistant…”
Get full text

Phase 1b Study of Abiraterone Acetate Plus Prednisone and Docetaxel in Patients with Metastatic Castration-resistant Prostate Cancer by Tagawa, Scott T, Posadas, Edwin M, Bruce, Justine, Lim, Emerson A, Petrylak, Daniel P, Peng, Weimin, Kheoh, Thian, Maul, Scott, Smit, Johan W, Gonzalez, Martha D, De Porre, Peter, Tran, NamPhuong, Nanus, David M

“…Abstract Coadministration of docetaxel and abiraterone acetate plus prednisone (AA + P) may benefit patients with metastatic castration-resistant prostate…”
Get full text

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan by Jonker, Johan W., Smit, Johan W., Brinkhuis, Remco F., Maliepaard, Marc, Beijnen, Jos H., Schellens, Jan H. M., Schinkel, Alfred H.

“…Background and Methods: Breast cancer resistance protein (BCRP/MXR/ABCP) is a multidrug-resistance protein that is a member of the adenosine…”
Get full text

Interactions between P‐glycoprotein substrates and other cationic drugs at the hepatic excretory level by Smit, Johan W., Duin, Erik, Steen, Herman, Oosting, Roelof, Roggeveld, Jan, Meijer, Dirk K F.

“…In the present study it was tested whether known P‐glycoprotein (P‐gp) substrates/MDR reversal agents interact with small (type 1) and bulky (type 2) cationic…”
Get full text

Population Pharmacokinetics of Tapentadol Immediate Release (IR) in Healthy Subjects and Patients with Moderate or Severe Pain by Xu, Xu Steven, Smit, Johan W., Lin, Rachel, Stuyckens, Kim, Terlinden, Rolf, Nandy, Partha

“…Background Tapentadol is a new, centrally active analgesic agent with two modes of action — ώ, opioid receptor agonism and norepinephrine reuptake inhibition —…”
Get full text

Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects by Hoeben, Eef, Smit, Johan W., Upmalis, David, Rusch, Sarah, Schaffler, Klaus, Reitmeir, Peter, Mangold, Bernhard

“…The analgesic/antihyperalgesic efficacy and dose-response relationship of 2 opioids was demonstrated in a human experimental algesimetric model using laser…”
Get full text

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure by Smit, J W, Huisman, M T, van Tellingen, O, Wiltshire, H R, Schinkel, A H

“…It was recently shown that naturally occurring Mdr1a mutant fetuses of the CF-1 outbred mouse stock have no placental Mdr1a P-glycoprotein (P-gp) and that this…”
Get full text

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs by HUISMAN, Maarten T, SMIT, Johan W, CROMMENTUYN, Kristel M. L, ZELCER, Noam, WILTSHIRE, Hugh R, BEIJNEN, Jos H, SCHINKEL, Alfred H

“…Various drug transporters of the ATP-binding cassette (ABC) family restrict the oral bioavailability and cellular, brain, testis, cerebrospinal fluid and fetal…”
Get full text

Effects of Acetaminophen, Naproxen, and Acetylsalicylic Acid on Tapentadol Pharmacokinetics: Results of Two Randomized, Open-Label, Crossover, Drug-Drug Interaction Studies by Smit, Johan W., Oh, Charles, Rengelshausen, Jens, Terlinden, Rolf, Ravenstijn, Paulien G. M., Wang, Shean-Sheng, Upmalis, David, Mangold, Bernhard

“…Study Objective. To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic…”
Get full text

Limited Oral Bioavailability and Active Epithelial Excretion of Paclitaxel (Taxol) Caused by P-glycoprotein in the Intestine by Sparreboom, Alex, Van Asperen, Judith, Mayer, Ulrich, Schinkel, Alfred H., Smit, Johan W., Dirk K. F. Meijer, Borst, Piet, Nooijen, Willem J., Beijnen, Jos H., Van Tellingen, Olaf

“…In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause multidrug resistance in tumor cells by lowering intracellular drug levels…”
Get full text