Search Results - "SMINIA, Peter"

Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas by Brandsma, Dieta, MD, Stalpers, Lukas, MD, Taal, Walter, MD, Sminia, Peter, PhD, van den Bent, Martin J, Prof

“…Summary Since the introduction of chemoradiotherapy with temozolomide as the new standard of care for patients with glioblastoma, there has been an increasing…”
Get full text

Reirradiation Tolerance of the Human Brain by Mayer, Ramona, M.D., M.Sc, Sminia, Peter, Ph.D

“…Purpose To give an overview of current available clinical data on reirradiation of glioma with respect to the tolerance dose of normal brain tissue. Methods…”
Get full text

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities by Narayan, Ravi S., Molenaar, Piet, Teng, Jian, Cornelissen, Fleur M. G., Roelofs, Irene, Menezes, Renee, Dik, Rogier, Lagerweij, Tonny, Broersma, Yoran, Petersen, Naomi, Marin Soto, Jhon Alexander, Brands, Eelke, van Kuiken, Philip, Lecca, Maria C., Lenos, Kristiaan J., In ‘t Veld, Sjors G. J. G., van Wieringen, Wessel, Lang, Frederick F., Sulman, Erik, Verhaak, Roel, Baumert, Brigitta G., Stalpers, Lucas J. A., Vermeulen, Louis, Watts, Colin, Bailey, David, Slotman, Ben J., Versteeg, Rogier, Noske, David, Sminia, Peter, Tannous, Bakhos A., Wurdinger, Tom, Koster, Jan, Westerman, Bart A.

“…Personalized cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. Here we present an…”
Get full text

External beam radiotherapy of recurrent glioma: radiation tolerance of the human brain by Sminia, Peter, Mayer, Ramona

“…Malignant gliomas relapse in close proximity to the resection site, which is the postoperatively irradiated volume. Studies on re-irradiation of glioma were…”
Get full text

Radiobiological Aspects of FLASH Radiotherapy by Hageman, Eline, Che, Pei-Pei, Dahele, Max, Slotman, Ben J, Sminia, Peter

“…Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical use of RT requires a balance to be struck between tumor effect…”
Get full text

Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model by FRANKEN, NICOLAAS A.P, OEI, ARLENE L, KOK, H. PETRA, RODERMOND, HANS M, SMINIA, PETER, CREZEE, JOHANNES, STALPERS, LUKAS J.A, BARENDSEN, GERRIT W

“…The linear-quadratic model (LQ model) provides a biologically plausible and experimentally established method to quantitatively describe the dose-response to…”
Get full text

Comparable cell survival between high dose rate flattening filter free and conventional dose rate irradiation by Verbakel, Wilko F A R, van den Berg, Jaap, Slotman, Ben J, Sminia, Peter

“…Investigation of clonogenic cell survival and cell proliferation following single dose and fractionated delivery of high dose rate flattening filter free (FFF)…”
Get more information

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models by Che, Pei Pei, Gregori, Alessandro, Firuzi, Omidreza, Dahele, Max, Sminia, Peter, Peters, Godefridus J, Giovannetti, Elisa

“…Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor response to chemo- and (modest-dose conventionally fractionated) radio-therapy. Emerging evidence…”
Get full text

Angiogenesis-Independent Tumor Growth Mediated by Stem-Like Cancer Cells by Sakariassen, Per Ø., Prestegarden, Lars, Wang, Jian, Skaftnesmo, Kai-Ove, Mahesparan, Rupavathana, Molthoff, Carla, Sminia, Peter, Sundlisæter, Eirik, Misra, Anjan, Tysnes, Berit Bølge, Chekenya, Martha, Peters, Hans, Lende, Gabriel, Kalland, Karl Henning, Øyan, Anne M., Petersen, Kjell, Jonassen, Inge, van der Kogel, Albert, Feuerstein, Burt G., Terzis, A. Jorge A., Bjerkvig, Rolf, Enger, Per Øyvind

“…In this work, highly infiltrative brain tumors with a stem-like phenotype were established by xenotransplantation of human brain tumors in immunodeficient nude…”
Get full text

Targeting the Akt-pathway to improve radiosensitivity in glioblastoma by Narayan, Ravi S, Fedrigo, Carlos Alexandre, Stalpers, Lukas J A, Baumert, Brigitta G, Sminia, Peter

“…Glioblastoma multiforme (GMB) is the most malignant and common type of all astrocytic tumors. Current standard of care entails maximum surgical resection of…”
Get more information

Radical radiotherapy for invasive bladder cancer: What dose and fractionation schedule to choose? by Pos, Floris J, Hart, Guus, Schneider, Christoph, Sminia, Peter

“…To establish the alpha/beta ratio of bladder cancer from different radiotherapy schedules reported in the literature and provide guidelines for the design of…”
Get more information

Differential Radiosensitizing Potential of Temozolomide in MGMT Promoter Methylated Glioblastoma Multiforme Cell Lines by van Nifterik, Krista A., M.Sc, van den Berg, Jaap, B.S, Stalpers, Lukas J.A., M.D., Ph.D, Lafleur, M. Vincent M., Ph.D, Leenstra, Sieger, M.D., Ph.D, Slotman, Ben J., M.D., Ph.D, Hulsebos, Theo J.M., Ph.D, Sminia, Peter, Ph.D

“…Purpose To investigate the radiosensitizing potential of temozolomide (TMZ) for human glioblastoma multiforme (GBM) cell lines using single-dose and…”
Get full text

Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells by Bijnsdorp, Irene V, van den Berg, Jaap, Kuipers, Gitta K, Wedekind, Laurine E, Slotman, Ben J, van Rijn, Johannes, Lafleur, M Vincent M, Sminia, Peter

“…The COX-2 protein is frequently overexpressed in human malignant gliomas. This expression has been associated with their aggressive growth characteristics and…”
Get full text

Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: Independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration by Kuipers, Gitta K., Slotman, Ben J., Wedekind, Laurine E., Stoter, T. Rianne, van den Berg, Jaap, Sminia, Peter, Lafleur, M. Vincent M.

“…Purpose: Patients with a malignant glioma have a very poor prognosis. Cyclooxygenase-2 (COX-2) protein is regularly upregulated in gliomas and might be a…”
Get full text

Lymphatic fistulas: obliteration by low-dose radiotherapy by Mayer, Ramona, Sminia, Peter, McBride, William H, Stranzl, Heidi, Prettenhofer, Ulrike, Fruhwirth, Johannes, Poschauko, Johann

“…Lymphatic drainage from the surgical wound is an uncommon but challenging complication of surgical intervention. Protracted lymphorrhea contributes to…”
Get full text

Effects of irradiation and cisplatin on human glioma spheroids : inhibition of cell proliferation and cell migration by FEHLAUER, Fabian, MUENCH, Martina, RADES, Dirk, STALPERS, Lukas J. A, LEENSTRA, Sieger, VAN DER VALK, Paul, SLOTMAN, Ben, SMID, Ernst J, SMINIA, Peter

“…Investigation of cell migration and proliferation of human glioma cell line spheroids (CLS) and evaluation of morphology, apoptosis, and immunohistochemical…”
Get full text

The optimal fraction size in high-dose-rate brachytherapy: dependency on tissue repair kinetics and low-dose rate by Sminia, Peter, Schneider, Christoph J, Fowler, Jack F

“…Indications of the existence of long repair half-times on the order of 2-4 h for late-responding human normal tissues have been obtained from continuous…”
Get more information

Differential Sensitivity to Ionizing Radiation in Gemcitabine-Resistant and Paclitaxel-Resistant Pancreatic Cancer Cells by Che, Pei Pei, Gregori, Alessandro, Bergonzini, Cecilia, Ali, Mahsoem, Mantini, Giulia, Schmidt, Thomas, Finamore, Francesco, Rodrigues, Stephanie M. Fraga, Frampton, Adam E., McDonnell, Liam A., Danen, Erik H., Slotman, Ben J., Sminia, Peter, Giovannetti, Elisa

“…Chemoresistance remains a major challenge in treating pancreatic ductal adenocarcinoma (PDAC). Although chemoradiation has proven effective in other tumor…”
Get full text

Comment on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis by Che, Pei Pei, Gregori, Alessandro, Peters, Godefridus J., Dahele, Max, Sminia, Peter, Giovannetti, Elisa

Get full text

WEE1 kinase inhibitor MK-1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status by Al-Jamaei, Aisha A Hussein, de Visscher, Jan G A M, Ramadugula, V Subramanyam, Forouzanfar, Tymour, Sminia, Peter, Doulabi, Behrouz Zandieh, Helder, Marco N

“…Oral tongue squamous cell carcinoma (OTSCC) frequently harbors non-functional p53 and depends on G2/M checkpoint mediated by WEE1. WEE1 suppression has been…”
Get full text