Search Results - "SMETANA JR, KAREL"

Cancer Microenvironment: What Can We Learn from the Stem Cell Niche by Lacina, Lukas, Plzak, Jan, Kodet, Ondrej, Szabo, Pavol, Chovanec, Martin, Dvorankova, Barbora, Smetana, Jr, Karel

“…Epidermal stem cells (ESCs) are crucial for maintenance and self- renewal of skin epithelium and also for regular hair cycling. Their role in wound healing is…”
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Ageing as an Important Risk Factor for Cancer by Smetana, Jr, Karel, Lacina, Lukáš, Szabo, Pavol, Dvořánková, Barbora, Brož, Prokop, Šedo, Aleksi

“…An ageing population is a typical feature of many developed countries across the world. Analyzed from a biomedical and philosophical point of view, this…”
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The Miniature Pig as an Animal Model in Biomedical Research by VODIČKA, PETR, SMETANA JR, KAREL, DVOŘÁNKOVÁ, BARBORA, EMERICK, TERESA, XU, YINGZHI Z., OUREDNIK, JITKA, OUREDNIK, VÁCLAV, MOTLÍK, JAN

“…: Crucial prerequisites for the development of safe preclinical protocols in biomedical research are suitable animal models that would allow for human‐related…”
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Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization by Gál, Peter, Vasilenko, Tomáš, Kostelníková, Martina, Jakubčo, Ján, Kováč, Ivan, Sabol, František, André, Sabine, Kaltner, Herbert, Gabius, Hans-Joachim, Smetana, Karel, Jr

“…Galectins are a family of carbohydrate-binding proteins that modulate inflammation and immunity. This functional versatility prompted us to perform a…”
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Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality by Smetana, Jr, Karel, Rosel, Daniel, BrÁbek, Jan

“…The FDA-approved drugs raloxifene and bazedoxifene could be among the best candidates to prevent mortality in severe COVID-19 patients. Raloxifene and…”
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Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications by Smetana, Jr, Karel, Brábek, Jan

“…COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction…”
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Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale by Šáchová, Jana, Čapková, Markéta, Strnad, Hynek, Kolář, Michal, Hroudová, Miluše, Chovanec, Martin, Čada, Zdeněk, Šteffl, Martin, Valach, Jaroslav, Kastner, Jan, Vlček, Čestmír, Smetana, Karel, Plzak, Jan

“…With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We…”
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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities by Rašková, Magdalena, Lacina, Lukáš, Kejík, Zdeněk, Venhauerová, Anna, Skaličková, Markéta, Kolář, Michal, Jakubek, Milan, Rosel, Daniel, Smetana, Jr, Karel, Brábek, Jan

“…Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range…”
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Effect of Atropa belladonna L. on skin wound healing: Biomechanical and histological study in rats and in vitro study in keratinocytes, 3T3 fibroblasts, and human umbilical vein endothelial cells by Gál, Peter, Toporcer, Tomáš, Grendel, Tomáš, Vidová, Zuzana, Smetana Jr, Karel, Dvořánková, Barbora, Gál, Tomáš, Mozeš, Štefan, Lenhardt, L'udovít, Longauer, František, Sabol, Marián, Sabo, Ján, Bačkor, Martin

“…ABSTRACT The effect of Atropa belladonna L. (AB) aqueous extract on skin wound healing was studied in male Sprague–Dawley rats subjected to two parallel…”
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Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review) by Kodet, Ondřej, Kučera, Jan, Strnadová, Karolína, Dvořánková, Barbora, Štork, Jiří, Lacina, Lukáš, Smetana, Jr, Karel

“…The incidence of cutaneous malignant melanoma has been steadily increasing worldwide for several decades. This phenomenon seems to follow the trend observed in…”
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Expression of Selected miRNAs in Normal and Cancer-Associated Fibroblasts and in BxPc3 and MIA PaCa-2 Cell Lines of Pancreatic Ductal Adenocarcinoma by Mandys, Václav, Popov, Alexey, Gürlich, Robert, Havránek, Jan, Pfeiferová, Lucie, Kolář, Michal, Vránová, Jana, Smetana, Jr, Karel, Lacina, Lukáš, Szabo, Pavol

“…Therapy for pancreatic ductal adenocarcinoma remains challenging, and the chances of a complete cure are very limited. As in other types of cancer, the…”
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Unravelling heterogeneous effects of cancer‑associated fibroblasts on poor prognosis markers in breast cancer EM‑G3 cell line: In vitro ‑targeted treatment (anti‑IL-6, anti‑VEGF-A, anti‑MFGE8) based on transcriptomic profiling by Urban, Lukáš, Novák, Štepán, Čoma, Matúš, Dvořánková, Barbora, Lacina, Lukáš, Šáchová, Jana, Hradilová, Miluše, Svatoňová, Petra, Kolář, Michal, Strnad, Hynek, Březinová, Jana, Smetana, Jr, Karel, Gál, Peter, Szabo, Pavol

“…Breast cancer is the most frequently diagnosed cancer in women worldwide. Although dramatically increased survival rates of early diagnosed cases have been…”
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Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery by Procházka, Vladimír, Lacina, Lukáš, Smetana, Jr, Karel, Svoboda, Martin, Skřivanová, Kateřina, Beňovská, Miroslava, Jarkovský, Jiří, Křen, Leoš, Kala, Zdeněk

“…The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective…”
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Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma by Melegová, Nikola, Čoma, Matúš, Urban, Lukáš, Kaňuchová, Miriam, Szabo, Pavol, Smetana, Jr, Karel, Mučaji, Pavel, Gál, Peter

“…Fibroblasts are actively involved in the formation of granulation tissue and/or tumor stroma. These cells possess the potential to differentiate into…”
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Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study by Kučera, Jan, Strnadová, Karolína, Dvořánková, Barbora, Lacina, Lukáš, Krajsová, Ivana, Štork, Jiří, Kovářová, Hana, Skalníková, Helena Kupcová, Vodička, Petr, Motlík, Jan, Dundr, Pavel, Smetana, Jr, Karel, Kodet, Ondřej

“…The steadily increasing incidence of malignant melanoma (MM) and its aggressive behaviour makes this tumour an attractive cancer research topic. The tumour…”
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Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells by Groza, Yaroslava, Lacina, Lukáš, Kuchař, Milan, Rašková Kafková, Leona, Zachová, Kateřina, Janoušková, Olga, Osička, Radim, Černý, Jiří, Petroková, Hana, Mierzwicka, Joanna Maria, Panova, Natalya, Kosztyu, Petr, Sloupenská, Kristýna, Malý, Jan, Škarda, Jozef, Raška, Milan, Smetana, Jr, Karel, Malý, Petr

“…Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune…”
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Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors by Valach, Jaroslav, Fík, Zdeněk, Strnad, Hynek, Chovanec, Martin, Plzák, Jan, Čada, Zdeněk, Szabo, Pavol, Šáchová, Jana, Hroudová, Miluše, Urbanová, Markéta, Šteffl, Martin, Pačes, Jan, Mazánek, Jiří, Vlček, Čestmír, Betka, Jan, Kaltner, Herbert, André, Sabine, Gabius, Hans-Joachim, Kodet, Roman, Smetana Jr, Karel, Gál, Peter, Kolář, Michal

“…Tumor stroma is an active part influencing the biological properties of malignancies via molecular cross‐talk. Cancer‐associated fibroblasts play a significant…”
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Immunocyto- and histochemical profiling of nucleostemin expression: Marker of epidermal stem cells? by Lacina, Lukáš, Smetana, Karel, Dvořánková, Barbora, Štork, Jiří, Plzáková, Zuzana, Gabius, Hans-Joachim

“…Because the nucleolar protein nucleostemin is present in bone marrow and neuronal stem cells and malignancies originating thereof we monitored its expression…”
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Functional differences between neonatal and adult fibroblasts and keratinocytes: Donor age affects epithelial-mesenchymal crosstalk in vitro by Mateu, Rosana, Živicová, Veronika, Krejčí, Eliška Drobná, Grim, Miloš, Strnad, Hynek, Vlček, Čestmír, Kolář, Michal, Lacina, Lukáš, Gál, Peter, Borský, Jiří, Smetana, Karel, Dvořánková, Barbora

“…Clinical evidence suggests that healing is faster and almost scarless at an early neonatal age in comparison with that in adults. In this study, the phenotypes…”
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Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses by Kolář, Michal, Szabo, Pavol, Dvořánková, Barbora, Lacina, Lukáš, Gabius, Hans-Joachim, Strnad, Hynek, Šáchová, Jana, Vlček, Čestmír, Plzák, Jan, Chovanec, Martin, Čada, Zdeněk, Betka, Jan, Fík, Zdeněk, Pačes, Jan, Kovářová, Hana, Motlík, Jan, Jarkovská, Karla, Smetana Jr, Karel

“…Background information Considering an analogy between wound healing and tumour progression, we studied chemokine and cytokine transcription and expression in…”
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