Search Results - "SMART, Melissa"

Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits by Hannon, Eilis, Gorrie-Stone, Tyler J., Smart, Melissa C., Burrage, Joe, Hughes, Amanda, Bao, Yanchun, Kumari, Meena, Schalkwyk, Leonard C., Mill, Jonathan

“…Characterizing the complex relationship between genetic, epigenetic, and transcriptomic variation has the potential to increase understanding about the…”
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Systematic underestimation of the epigenetic clock and age acceleration in older subjects by El Khoury, Louis Y, Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C

“…The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used…”
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Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child by Miettinen, Maija E, Smart, Melissa C, Kinnunen, Leena, Harjutsalo, Valma, Reinert-Hartwall, Linnea, Ylivinkka, Irene, Surcel, Heljä-Marja, Lamberg-Allardt, Christel, Hitman, Graham A, Tuomilehto, Jaakko

“…The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in…”
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Bigmelon: tools for analysing large DNA methylation datasets by Gorrie-Stone, Tyler J, Smart, Melissa C, Saffari, Ayden, Malki, Karim, Hannon, Eilis, Burrage, Joe, Mill, Jonathan, Kumari, Meena, Schalkwyk, Leonard C

“…Abstract Motivation The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and…”
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Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations by Prins, Bram P., Kuchenbaecker, Karoline B., Bao, Yanchun, Smart, Melissa, Zabaneh, Delilah, Fatemifar, Ghazaleh, Luan, Jian’an, Wareham, Nick J., Scott, Robert A., Perry, John R. B., Langenberg, Claudia, Benzeval, Michaela, Kumari, Meena, Zeggini, Eleftheria

“…Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to gain insights into the genetic architecture of biomarker traits…”
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Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates by Hillman, Sara L, Finer, Sarah, Smart, Melissa C, Mathews, Chris, Lowe, Robert, Rakyan, Vardhman K, Hitman, Graham A, Williams, David J

“…Fetal growth is determined by the feto-placental genome interacting with the maternal in utero environment. Failure of this interplay leads to poor placental…”
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Gene-environment interactions between education and body mass: Evidence from the UK and Finland by Amin, Vikesh, Böckerman, Petri, Viinikainen, Jutta, Smart, Melissa C., Bao, Yanchun, Kumari, Meena, Pitkänen, Niina, Lehtimäki, Terho, Raitakari, Olli, Pehkonen, Jaakko

“…More education is associated with a lower body mass index (BMI) and likelihood of being overweight. However, since a large proportion of the variation in body…”
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Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring by Miettinen, Maija E., Smart, Melissa C., Kinnunen, Leena, Mathews, Christopher, Harjutsalo, Valma, Surcel, Heljä-Marja, Lamberg-Allardt, Christel, Tuomilehto, Jaakko, Hitman, Graham A.

“…Aims/hypothesis We investigated whether single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentration in the metabolic pathway of…”
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The effect of age and gender on the genetic regulation of serum 25-hydroxyvitamin D - the FIN-D2D population-based study by Miettinen, Maija E., Smart, Melissa C., Kinnunen, Leena, Keinänen-Kiukaanniemi, Sirkka, Moilanen, Leena, Puolijoki, Hannu, Saltevo, Juha, Oksa, Heikki, Hitman, Graham A., Tuomilehto, Jaakko, Peltonen, Markku

“…•Vitamin D status (serum 25OHD) is partly dependent on inherited factors.•We studied if the genetic determinants of serum 25OHD are age and…”
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A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans by Bejar, Cynthia A, Goyal, Shiwali, Afzal, Shoaib, Mangino, Massimo, Zhou, Ang, van der Most, Peter J, Bao, Yanchun, Gupta, Vipin, Smart, Melissa C, Walia, Gagandeep K, Verweij, Niek, Power, Christine, Prabhakaran, Dorairaj, Singh, Jai Rup, Mehra, Narinder K, Wander, Gurpreet S, Ralhan, Sarju, Kinra, Sanjay, Kumari, Meena, de Borst, Martin H, Hyppönen, Elina, Spector, Tim D, Nordestgaard, Børge G, Blackett, Piers R, Sanghera, Dharambir K

“…Multiple observational studies have reported an inverse relationship between 25-hydroxyvitamin D concentrations (25(OH)D) and type 2 diabetes (T2D). However,…”
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The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk by Smart-Halajko, Melissa C, Robciuc, Marius R, Cooper, Jackie A, Jauhiainen, Matti, Kumari, Meena, Kivimaki, Mika, Khaw, Kay-Tee, Boekholdt, S. Matthijs, Wareham, Nicholas J, Gaunt, Tom R, Day, Ian N, Braund, Peter S, Nelson, Christopher P, Hall, Alistair S, Samani, Nilesh J, Humphries, Steve E, Ehnholm, Christian, Talmud, Philippa J

“…OBJECTIVE—To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants…”
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ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial by Smart-Halajko, Melissa C, Kelley-Hedgepeth, Alyson, Montefusco, Maria Claudia, Cooper, Jackie A, Kopin, Alan, McCaffrey, Jeanne M, Balasubramanyam, Ashok, Pownall, Henry J, Nathan, David M, Peter, Inga, Talmud, Philippa J, Huggins, Gordon S

“…Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma…”
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ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity by Ntalla, Ioanna, Dedoussis, George, Yannakoulia, Mary, Smart, Melissa C, Louizou, Eirini, Sakka, Sophia D, Papoutsakis, Constantina, Talmud, Philippa J

“…Background Adiponectin, an adipose-derived hormone with central and peripheral actions, is involved in the regulation of energy homeostasis. Interactions…”
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The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of Tumorigenesis by DARCY, Vivien, ABDULLAEV, Ziedulla K, RICHARD, Carlos, DELGADO, M. Dolores, LOBANENKOV, Victor, KLENOVA, Elena, PORE, Naresh, DOCQUIER, France, TORRANO, Veronica, CHERNUKHIN, Igor, SMART, Melissa, FARRAR, Dawn, METODIEV, Metodi, FERNANDEZ, Nelson

“…Purpose: B rother o f the r egulator of i mprinted s ites (BORIS) is a novel member of the cancer-testis antigen gene family. These genes are normally…”
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Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring by Finer, Sarah, Mathews, Chris, Lowe, Rob, Smart, Melissa, Hillman, Sara, Foo, Lin, Sinha, Ajay, Williams, David, Rakyan, Vardhman K, Hitman, Graham A

“…Exposure of a developing foetus to maternal gestational diabetes (GDM) has been shown to programme future risk of diabetes and obesity. Epigenetic variation in…”
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Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course by Hughes, Amanda, Smart, Melissa, Gorrie-Stone, Tyler, Hannon, Eilis, Mill, Jonathan, Bao, Yanchun, Burrage, Joe, Schalkwyk, Leo, Kumari, Meena

“…Abstract Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position…”
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Multivariate genome-wide analyses of the well-being spectrum by Baselmans, Bart M. L., Jansen, Rick, Ip, Hill F., van Dongen, Jenny, Abdellaoui, Abdel, van de Weijer, Margot P., Bao, Yanchun, Smart, Melissa, Kumari, Meena, Willemsen, Gonneke, Hottenga, Jouke-Jan, Boomsma, Dorret I., de Geus, Eco J. C., Nivard, Michel G., Bartels, Meike

“…We introduce two novel methods for multivariate genome-wide-association meta-analysis (GWAMA) of related traits that correct for sample overlap. A broad range…”
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Assessing the robustness of sisVIVE in a Mendelian randomization study to estimate the causal effect of body mass index on income using multiple SNPs from understanding society by Bao, Yanchun, Clarke, Paul S., Smart, Melissa, Kumari, Meena

“…The “some invalid, some valid instrumental variable estimator” (sisVIVE) is a lasso‐based method for instrumental variables (IVs) regression of outcome on an…”
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THE AUTHORS REPLY by Hughes, Amanda, Bao, Yanchun, Smart, Melissa, Gorrie-Stone, Tyler, Hannon, Eilis, Mill, Jonathan, Burrage, Joe, Schalkwyk, Leo, Kumari, Meena

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THE AUTHORS REPLY by Hughes, Amanda, Bao, Yanchun, Smart, Melissa, Gorrie-Stone, Tyler, Hannon, Eilis, Mill, Jonathan, Burrage, Joe, Schalkwyk, Leo, Kumari, Meena

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