Search Results - "SMALLWOOD, Philip"

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation by Cho, Chris, Smallwood, Philip M., Nathans, Jeremy

“…Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPCR, have been implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that…”
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Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina by Zhou, Yulian, Williams, John, Smallwood, Philip M, Nathans, Jeremy

“…Vascular development and maintenance are controlled by a complex transcriptional program, which integrates both extracellular and intracellular signals in…”
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Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity by Wang, Yanshu, Rattner, Amir, Zhou, Yulian, Williams, John, Smallwood, Philip M., Nathans, Jeremy

“…Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically engineered mice, we show that…”
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Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease by Wu, Hao, Luo, Junjie, Yu, Huimin, Rattner, Amir, Mo, Alisa, Wang, Yanshu, Smallwood, Philip M, Erlanger, Bracha, Wheelan, Sarah J, Nathans, Jeremy

“…Female eutherian mammals use X chromosome inactivation (XCI) to epigenetically regulate gene expression from ∼4% of the genome. To quantitatively map the…”
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Canonical WNT signaling components in vascular development and barrier formation by Zhou, Yulian, Wang, Yanshu, Tischfield, Max, Williams, John, Smallwood, Philip M, Rattner, Amir, Taketo, Makoto M, Nathans, Jeremy

“…Canonical WNT signaling is required for proper vascularization of the CNS during embryonic development. Here, we used mice with targeted mutations in genes…”
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Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance by Wang, Yanshu, Cho, Chris, Williams, John, Smallwood, Philip M., Zhang, Chi, Junge, Harald J., Nathans, Jeremy

“…β-Catenin signaling controls the development and maintenance of the blood–brain barrier (BBB) and the blood–retina barrier (BRB), but the division of labor and…”
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A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy by Wang, Yanshu, Smallwood, Philip M, Williams, John, Nathans, Jeremy

“…During mitosis, Kif11, a kinesin motor protein, promotes bipolar spindle formation and chromosome movement, and during interphase, Kif11 mediates diverse…”
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Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis by Peng, Xi, Williams, John, Smallwood, Philip M, Nathans, Jeremy

“…The Amyloid Precursor Protein (APP) and Contactin (CNTN) families of cell-surface proteins have been intensively studied in the context of neural development…”
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Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization by Ye, Xin, Wang, Yanshu, Cahill, Hugh, Yu, Minzhong, Badea, Tudor C., Smallwood, Philip M., Peachey, Neal S., Nathans, Jeremy

“…Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5…”
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The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development by Wang, Yanshu, Venkatesh, Arjun, Xu, Jiajia, Xu, Mingxin, Williams, John, Smallwood, Philip M, James, Aaron, Nathans, Jeremy

“…In central nervous system vascular endothelial cells, signaling via the partially redundant ligands WNT7A and WNT7B requires two co-activator proteins, GPR124…”
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Utility of protein–protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display by Zhu, Ningyu, Smallwood, Philip M., Rattner, Amir, Chang, Tao-Hsin, Williams, John, Wang, Yanshu, Nathans, Jeremy

“…Over the past 3 decades, a diverse collection of small protein domains have been used as scaffolds to generate general purpose protein-binding reagents using a…”
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Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development by Cho, Chris, Wang, Yanshu, Smallwood, Philip M, Williams, John, Nathans, Jeremy

“…The molecular basis of Wnt-Frizzled specificity is a central question in developmental biology. Reck, a multi-domain and multi-functional…”
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Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles by Chang, Hao, Cahill, Hugh, Smallwood, Philip M, Wang, Yanshu, Nathans, Jeremy

“…Planar cell polarity (PCP) signaling controls the global orientation of surface structures, such as hairs and bristles, in both vertebrates and invertebrates…”
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The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation by Chang, Hao, Smallwood, Philip M., Williams, John, Nathans, Jeremy

“…In mammals, hair follicles cover most of the body surface and exhibit precise and stereotyped orientations relative to the body axes. Follicle orientation is…”
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Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes by Yu, Huimin, Smallwood, Philip M, Wang, Yanshu, Vidaltamayo, Roman, Reed, Randall, Nathans, Jeremy

“…The closure of an open anatomical structure by the directed growth and fusion of two tissue masses is a recurrent theme in mammalian embryology, and this…”
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Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae by Chang, Tao-Hsin, Hsieh, Fu-Lien, Gu, Xiaowu, Smallwood, Philip M, Kavran, Jennifer M, Gabelli, Sandra B, Nathans, Jeremy

“…In many organs, small openings across capillary endothelial cells (ECs) allow the diffusion of low-molecular weight compounds and small proteins between the…”
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New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling by Badea, Tudor C, Hua, Zhong L, Smallwood, Philip M, Williams, John, Rotolo, Thomas, Ye, Xin, Nathans, Jeremy

“…Pharmacologic control of Cre-mediated recombination using tamoxifen-dependent activation of a Cre-estrogen receptor ligand binding domain fusion protein…”
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Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers by Cho, Chris, Wang, Yanshu, Smallwood, Philip M, Williams, John, Nathans, Jeremy

“…Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs…”
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Structure of the RECK CC domain, an evolutionary anomaly by Chang, Tao-Hsin, Hsieh, Fu-Lien, Smallwood, Philip M., Gabelli, Sandra B., Nathans, Jeremy

“…Five small protein domains, the CC-domains, at the N terminus of the RECK protein, play essential roles in signaling by WNT7A and WNT7B in the context of…”
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Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology by Rotolo, Thomas, Smallwood, Philip M, Williams, John, Nathans, Jeremy

“…In mammals, genetically-directed cell labeling technologies have not yet been applied to the morphologic analysis of neurons with very large and complex…”
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