Search Results - "SLOTBOOM, Dirk J"

Elevator-type mechanisms of membrane transport by Garaeva, Alisa A, Slotboom, Dirk J

“…Membrane transporters are integral membrane proteins that mediate the passage of solutes across lipid bilayers. These proteins undergo conformational…”
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A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2 by Garaeva, Alisa A., Guskov, Albert, Slotboom, Dirk J., Paulino, Cristina

“…The human Alanine Serine Cysteine Transporter 2 (ASCT2) is a neutral amino acid exchanger that belongs to the solute carrier family 1 (SLC1A). SLC1A structures…”
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Cryo-EM structure of the human neutral amino acid transporter ASCT2 by Garaeva, Alisa A., Oostergetel, Gert T., Gati, Cornelius, Guskov, Albert, Paulino, Cristina, Slotboom, Dirk J.

“…Human ASCT2 belongs to the SLC1 family of secondary transporters and is specific for the transport of small neutral amino acids. ASCT2 is upregulated in cancer…”
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Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment by Arkhipova, Valentina, Guskov, Albert, Slotboom, Dirk J.

“…Glutamate transporters are cation-coupled secondary active membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft. These…”
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Chemiosmotic nutrient transport in synthetic cells powered by electrogenic antiport coupled to decarboxylation by Patiño-Ruiz, Miyer F., Anshari, Zaid Ramdhan, Gaastra, Bauke, Slotboom, Dirk J., Poolman, Bert

“…Cellular homeostasis depends on the supply of metabolic energy in the form of ATP and electrochemical ion gradients. The construction of synthetic cells…”
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Expulsion mechanism of the substrate-translocating subunit in ECF transporters by Thangaratnarajah, Chancievan, Nijland, Mark, Borges-Araújo, Luís, Jeucken, Aike, Rheinberger, Jan, Marrink, Siewert J., Souza, Paulo C. T., Paulino, Cristina, Slotboom, Dirk J.

“…Energy-coupling factor (ECF)-type transporters mediate the uptake of micronutrients in many bacteria. They consist of a substrate-translocating subunit…”
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Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA by Nijland, Mark, Lefebvre, Solène N., Thangaratnarajah, Chancievan, Slotboom, Dirk J.

“…BacA is a mycobacterial ATP-binding cassette (ABC) transporter involved in the translocation of water-soluble compounds across the lipid bilayer…”
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Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2 by Borowska, Anna M., Chiariello, Maria Gabriella, Garaeva, Alisa A., Rheinberger, Jan, Marrink, Siewert J., Paulino, Cristina, Slotboom, Dirk J.

“…ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular amino acid homeostasis. ASCT2 belongs to the same family (SLC1) as Excitatory…”
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Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6 by Colucci, Emanuela, Anshari, Zaid R., Patiño-Ruiz, Miyer F., Nemchinova, Mariia, Whittaker, Jacob, Slotboom, Dirk J., Guskov, Albert

“…Episodic ataxias (EAs) are rare neurological conditions affecting the nervous system and typically leading to motor impairment. EA6 is linked to the mutation…”
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Structural insight in the toppling mechanism of an energy-coupling factor transporter by Swier, Lotteke J. Y. M., Guskov, Albert, Slotboom, Dirk J.

“…Energy-coupling factor (ECF) transporters mediate uptake of micronutrients in prokaryotes. The transporters consist of an S-component that binds the…”
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Tuning Escherichia coli for membrane protein overexpression by Wagner, Samuel, Klepsch, Mirjam M, Schlegel, Susan, Appel, Ansgar, Draheim, Roger, Tarry, Michael, Högbom, Martin, van Wijk, Klaas J, Slotboom, Dirk J, Persson, Jan O, de Gier, Jan-Willem

“…A simple generic method for optimizing membrane protein overexpression in Escherichia coli is still lacking. We have studied the physiological response of the…”
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Models to determine the kinetic mechanisms of ion-coupled transporters by Lolkema, Juke S, Slotboom, Dirk J

“…With high-resolution structures available for many ion-coupled (secondary active) transporters, a major challenge for the field is to determine how coupling is…”
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High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS by Maity, Sourav, Trinco, Gianluca, Buzón, Pedro, Anshari, Zaid R, Kodera, Noriyuki, Ngo, Kien Xuan, Ando, Toshio, Slotboom, Dirk J, Roos, Wouter H

“…The secondary active transporter CitS shuttles citrate across the cytoplasmic membrane of gram-negative bacteria by coupling substrate translocation to the…”
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The structural basis of proton driven zinc transport by ZntB by Gati, Cornelius, Stetsenko, Artem, Slotboom, Dirk J., Scheres, Sjors H. W., Guskov, Albert

“…Zinc is an essential microelement to sustain all forms of life. However, excess of zinc is toxic, therefore dedicated import, export and storage proteins for…”
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Membrane mediated toppling mechanism of the folate energy coupling factor transporter by Faustino, Ignacio, Abdizadeh, Haleh, Souza, Paulo C. T., Jeucken, Aike, Stanek, Weronika K., Guskov, Albert, Slotboom, Dirk J., Marrink, Siewert J.

“…Energy coupling factor (ECF) transporters are responsible for the uptake of micronutrients in bacteria and archaea. They consist of an integral membrane unit,…”
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A Novel Class of Modular Transporters for Vitamins in Prokaryotes by Rodionov, Dmitry A, Hebbeln, Peter, Eudes, Aymerick, ter Beek, Josy, Rodionova, Irina A, Erkens, Guus B, Slotboom, Dirk J, Gelfand, Mikhail S, Osterman, Andrei L, Hanson, Andrew D, Eitinger, Thomas

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Binding and transport of D-aspartate by the glutamate transporter homolog GltTk by Arkhipova, Valentina, Trinco, Gianluca, Ettema, Thijs W, Jensen, Sonja, Slotboom, Dirk J, Guskov, Albert

“…Mammalian glutamate transporters are crucial players in neuronal communication as they perform neurotransmitter reuptake from the synaptic cleft. Besides…”
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In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters by Setyawati, Inda, Stanek, Weronika K, Majsnerowska, Maria, Swier, Lotteke J Y M, Pardon, Els, Steyaert, Jan, Guskov, Albert, Slotboom, Dirk J

“…Energy-coupling factor (ECF) transporters mediate import of micronutrients in prokaryotes. They consist of an integral membrane S-component (that binds…”
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An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis by Jochim, Angelika, Adolf, Lea, Belikova, Darya, Schilling, Nadine Anna, Setyawati, Inda, Chin, Denny, Meyers, Severien, Verhamme, Peter, Heinrichs, David E, Slotboom, Dirk J, Heilbronner, Simon

“…Energy-coupling factor type transporters (ECF) represent trace nutrient acquisition systems. Substrate binding components of ECF-transporters are membrane…”
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Functional and structural characterization of an ECF-type ABC transporter for vitamin B12 by Santos, Joana A, Rempel, Stephan, Mous, Sandra Tm, Pereira, Cristiane T, Ter Beek, Josy, de Gier, Jan-Willem, Guskov, Albert, Slotboom, Dirk J

“…Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively in a limited number of prokaryotes. Its biologically active variants…”
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