Search Results - "SLOT, Jason C."

Horizontal Transfer of a Large and Highly Toxic Secondary Metabolic Gene Cluster between Fungi by Slot, Jason C., Rokas, Antonis

“…Genes involved in intermediary and secondary metabolism in fungi are frequently physically linked or clustered. For example, in Aspergillus nidulans the entire…”
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CLOCI: unveiling cryptic fungal gene clusters with generalized detection by Konkel, Zachary, Kubatko, Laura, Slot, Jason C

“…Abstract Gene clusters are genomic loci that contain multiple genes that are functionally and genetically linked. Gene clusters collectively encode diverse…”
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Metabolic gene clusters, fungal diversity, and the generation of accessory functions by Slot, Jason C, Gluck-Thaler, Emile

“…•Many of life’s adaptive accessory functions are encoded in metabolic gene clusters.•Cluster evolution is intertwined with the processes generating accessory…”
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The evolution of fungal metabolic pathways by Wisecaver, Jennifer H, Slot, Jason C, Rokas, Antonis

“…Fungi contain a remarkable range of metabolic pathways, sometimes encoded by gene clusters, enabling them to digest most organic matter and synthesize an array…”
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Multiple GAL pathway gene clusters evolved independently and by different mechanisms in fungi by Slot, Jason C, Rokas, Antonis

“…A notable characteristic of fungal genomes is that genes involved in successive steps of a metabolic pathway are often physically linked or clustered. To…”
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The Evolutionary Imprint of Domestication on Genome Variation and Function of the Filamentous Fungus Aspergillus oryzae by Gibbons, John G., Salichos, Leonidas, Slot, Jason C., Rinker, David C., McGary, Kriston L., King, Jonas G., Klich, Maren A., Tabb, David L., McDonald, W. Hayes, Rokas, Antonis

“…The domestication of animals, plants, and microbes fundamentally transformed the lifestyle and demography of the human species [1]. Although the genetic and…”
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Comparative genomics of biotechnologically important yeasts by Riley, Robert, Haridas, Sajeet, Wolfe, Kenneth H., Lopes, Mariana R., Hittinger, Chris Todd, Göker, Markus, Salamov, Asaf A., Wisecaver, Jennifer H., Long, Tanya M., Calvey, Christopher H., Aerts, Andrea L., Barry, Kerrie W., Choi, Cindy, Clum, Alicia, Coughlan, Aisling Y., Deshpande, Shweta, Douglass, Alexander P., Hanson, Sara J., Klenk, Hans-Peter, LaButti, Kurt M., Lapidus, Alla, Lindquist, Erika A., Lipzen, Anna M., Meier-Kolthoff, Jan P., Ohm, Robin A., Otillar, Robert P., Pangilinan, Jasmyn L., Peng, Yi, Rokas, Antonis, Rosa, Carlos A., Scheuner, Carmen, Sibirny, Andriy A., Slot, Jason C., Stielow, J. Benjamin, Sun, Hui, Kurtzman, Cletus P., Blackwell, Meredith, Grigoriev, Igor V., Jeffries, Thomas W.

“…Ascomycete yeasts are metabolically diverse, with great potential for biotechnology. Here, we report the comparative genome analysis of 29 taxonomically and…”
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Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens by Gluck-Thaler, Emile, Slot, Jason C

“…  First in bacteria, and more recently in microscopic and even multicellular eukaryotes, horizontal gene transfer (HGT) has been implicated in genomic and…”
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Giant Starship Elements Mobilize Accessory Genes in Fungal Genomes by Gluck-Thaler, Emile, Ralston, Timothy, Konkel, Zachary, Ocampos, Cristhian Grabowski, Ganeshan, Veena Devi, Dorrance, Anne E., Niblack, Terry L., Wood, Corlett W., Slot, Jason C., Lopez-Nicora, Horacio D., Vogan, Aaron A.

“…Abstract Accessory genes are variably present among members of a species and are a reservoir of adaptive functions. In bacteria, differences in gene…”
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Physical linkage of metabolic genes in fungi is an adaptation against the accumulation of toxic intermediate compounds by McGary, Kriston L., Slot, Jason C., Rokas, Antonis

“…Genomic analyses have proliferated without being tied to tangible phenotypes. For example, although coordination of both gene expression and genetic linkage…”
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A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry by Castro-Moretti, Fernanda R, Cocuron, Jean-Christophe, Castillo-Gonzalez, Humberto, Escudero-Leyva, Efrain, Chaverri, Priscila, Guerreiro-Filho, Oliveiro, Slot, Jason C, Alonso, Ana Paula

“…Products of plant secondary metabolism, such as phenolic compounds, flavonoids, alkaloids, and hormones, play an important role in plant growth, development,…”
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Horizontal transfer of a nitrate assimilation gene cluster and ecological transitions in fungi: a phylogenetic study by Slot, Jason C, Hibbett, David S

“…High affinity nitrate assimilation genes in fungi occur in a cluster (fHANT-AC) that can be coordinately regulated. The clustered genes include nrt2, which…”
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Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes) by Merényi, Zsolt, Virágh, Máté, Gluck-Thaler, Emile, Slot, Jason C, Kiss, Brigitta, Varga, Torda, Geösel, András, Hegedüs, Botond, Bálint, Balázs, Nagy, László G

“…Multicellularity has been one of the most important innovations in the history of life. The role of gene regulatory changes in driving transitions to…”
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Evolution of a Heavy Metal Homeostasis/Resistance Island Reflects Increasing Copper Stress in Enterobacteria by Staehlin, Benjamin M, Gibbons, John G, Rokas, Antonis, O'Halloran, Thomas V, Slot, Jason C

“…Copper homeostasis in bacteria is challenged by periodic elevation of copper levels in the environment, arising from both natural sources and human inputs…”
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Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum by Olarte, Rodrigo A, Menke, Jon, Zhang, Ying, Sullivan, Shawn, Slot, Jason C, Huang, Yinyin, Badalamenti, Jonathan P, Quandt, Alisha C, Spatafora, Joseph W, Bushley, Kathryn E

“…Genes involved in production of secondary metabolites (SMs) in fungi are exceptionally diverse. Even strains of the same species may exhibit differences in…”
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In silico characterization and molecular evolutionary analysis of a novel superfamily of fungal effector proteins by Stergiopoulos, Ioannis, Kourmpetis, Yiannis A I, Slot, Jason C, Bakker, Freek T, De Wit, Pierre J G M, Rokas, Antonis

“…Most fungal plant pathogens secrete effector proteins during pathogenesis to manipulate their host's defense and promote disease. These are so highly diverse…”
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Two different secondary metabolism gene clusters occupied the same ancestral locus in fungal dermatophytes of the arthrodermataceae by Zhang, Han, Rokas, Antonis, Slot, Jason C

“…Dermatophyte fungi of the family Arthrodermataceae (Eurotiomycetes) colonize keratinized tissue, such as skin, frequently causing superficial mycoses in humans…”
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Correction: The Evolution of Fungal Metabolic Pathways by Wisecaver, Jennifer H, Slot, Jason C, Rokas, Antonis

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Fragmentation of an aflatoxin-like gene cluster in a forest pathogen by Bradshaw, Rosie E., Slot, Jason C., Moore, Geromy G., Chettri, Pranav, Wit, Pierre J. G. M., Ehrlich, Kenneth C., Ganley, Austen R. D., Olson, Malin A., Rokas, Antonis, Carbone, Ignazio, Cox, Murray P.

“…Plant pathogens use a complex arsenal of weapons, such as toxic secondary metabolites, to invade and destroy their hosts. Knowledge of how secondary metabolite…”
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Fungal Gene Cluster Diversity and Evolution by Slot, Jason C

“…Metabolic gene clusters (MGCs) have provided some of the earliest glimpses at the biochemical machinery of yeast and filamentous fungi. MGCs encode diverse…”
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