Search Results - "SLOAND, Elaine M"

Factors Affecting Response and Survival in Patients With Myelodysplasia Treated With Immunosuppressive Therapy by SLOAND, Elaine M, WU, Colin O, GREENBERG, Peter, YOUNG, Neal, BARRETT, John

“…Marrow failure in some patients with myelodysplastic syndrome (MDS) responds to immunosuppressive treatment (IST), but long-term outcome after IST has not been…”
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Alemtuzumab Treatment of Intermediate-1 Myelodysplasia Patients Is Associated With Sustained Improvement in Blood Counts and Cytogenetic Remissions by SLOAND, Elaine M, OLNES, Matthew J, YOUNG, Neal S, SHENOY, Aarthie, WEINSTEIN, Barbara, BOSS, Carol, LOELIGER, Kelsey, WU, Colin O, MORE, Kenneth, BARRETT, A. John, SCHEINBERG, Phillip

“…Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and progression to leukemia. Clinical and experimental evidence suggests an…”
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Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study by Scheinberg, Phillip, Wu, Colin O, Nunez, Olga, Scheinberg, Priscila, Boss, Carol, Sloand, Elaine M, Young, Neal S

“…1 Hematology Branch and 2 Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA…”
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The Role of the Immune System in Myelodysplasia: Implications for Therapy by Sloand, Elaine M, Rezvani, Katayoun

“…Patients with myelodysplastic syndrome (MDS) have intrinsic, usually acquired genetic defects in their hematopoietic stem cells, but some others exhibit…”
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Hematopoietic-specific microRNA expression in human cells by Ramkissoon, Shakti H., Mainwaring, Lori A., Ogasawara, Yoji, Keyvanfar, Keyvan, Philip McCoy, J., Sloand, Elaine M., Kajigaya, Sachiko, Young, Neal S.

“…We examined expression profiles of hematopoietic tissue-specific microRNAs (miRNAs; miR-142, miR-155, miR-181 and miR-223) in 17 commercially available…”
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Granulocyte Colony-Stimulating Factor Preferentially Stimulates Proliferation of Monosomy 7 Cells Bearing the Isoform IV Receptor by Sloand, Elaine M., Yong, Agnes S. M., Ramkissoon, Shakti, Solomou, Elena, Bruno, Tullia C., Kim, Sonnie, Fuhrer, Monika, Kajigaya, Sachiko, Barrett, A. John, Young, Neal S.

“…Granulocyte colony-stimulating factor (GCSF) administration has been linked to the development of monosomy 7 in severe congenital neutropenia and aplastic…”
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Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia by Maciejewski, Jaroslaw P., Risitano, Antonio, Sloand, Elaine M., Nunez, Olga, Young, Neal S.

“…A serious complication of aplastic anemia (AA) is its evolution to clonal hematologic diseases such as myelodysplasia (MDS) and leukemia, which is usually…”
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Hypocellular Myelodysplasia by Sloand, Elaine M., MD

“…Myelodysplasia must be considered in the differential diagnosis of patients who have bone marrow failure, but bone marrow cellularity per se may not…”
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Immunosuppression for Myelodysplastic Syndrome: How Bench to Bedside to Bench Research Led to Success by Sloand, Elaine M., MD, Barrett, A.J., MD

“…Laboratory evidence and clinical evidence suggest that some patients with myelodysplastic syndrome (MDS) have immunologically mediated disease. This article…”
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Long-term follow-up of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab by SLOAND, Elaine M, OLNES, Matthew J, WEINSTEIN, Barbara, COLIN WU, MACIEJEWSKI, Jaroslaw, SCHEINBERG, Phillip, YOUNG, Neal S

“…Pure red cell aplasia and moderate aplastic anemia are marrow failure states with an immune pathogenesis. Previously, we described short-term improvements in…”
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Association of Telomere Length of Peripheral Blood Leukocytes With Hematopoietic Relapse, Malignant Transformation, and Survival in Severe Aplastic Anemia by Scheinberg, Phillip, Cooper, James N, Sloand, Elaine M, Wu, Colin O, Calado, Rodrigo T, Young, Neal S

“…CONTEXT Critically short telomeres produce apoptosis, cell senescence, and chromosomal instability in tissue culture and animal models. Variations in telomere…”
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Myelodysplastic Syndromes: Introduction by Sloand, Elaine M., MD

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Targeting Immune Dysregulation in Myelodysplastic Syndromes by Olnes, Matthew J, Sloand, Elaine M

“…Myelodysplastic syndromes (MDS) are a heterogeneous group of bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop…”
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CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins by Sloand, Elaine M., Pfannes, Loretta, Chen, Gubin, Shah, Simant, Solomou, Elena E., Barrett, John, Young, Neal S.

“…CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) are distinguished from other MDS cells and from normal hematopoietic cells by their…”
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T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy by Sloand, Elaine M., Melenhorst, J. Joseph, Tucker, Zachary C.G., Pfannes, Loretta, Brenchley, Jason M., Yong, Agnes, Visconte, Valeria, Wu, Colin, Gostick, Emma, Scheinberg, Phillip, Olnes, Matthew J., Douek, Daniel C., Price, David A., Barrett, A. John, Young, Neal S.

“…Clinical observations and laboratory evidence link bone marrow failure in myelodysplastic syndrome (MDS) to a T cell–mediated immune process that is responsive…”
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Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia by Scheinberg, Phillip, Fischer, Steven H., Li, Li, Nunez, Olga, Wu, Colin O., Sloand, Elaine M., Cohen, Jeffrey I., Young, Neal S., John Barrett, A.

“…The natural history of EBV and CMV reactivation and the potential for serious complications following antibody-based immunosuppressive treatment for bone…”
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Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome by Sloand, Elaine M., Mainwaring, Lori, Fuhrer, Monika, Ramkissoon, Shakti, Risitano, Antonio M., Keyvanafar, Keyvan, Lu, Jun, Basu, Atanu, Barrett, A. John, Young, Neal S.

“…Clinical observations and experimental evidence link bone marrow failure in myelodysplastic syndrome (MD33) with a T cell–dominated autoimmune process…”
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Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na by Olnes, Matthew J, Shenoy, Aarthie, Weinstein, Barbara, Pfannes, Loretta, Loeliger, Kelsey, Tucker, Zachary, Tian, Xin, Kwak, Minjung, Wilhelm, Francois, Yong, Agnes S.M, Maric, Irina, Maniar, Manoj, Scheinberg, Phillip, Groopman, Jerome, Young, Neal S, Sloand, Elaine M

“…Abstract Background We previously demonstrated upregulation of c-myc, survivin, and cyclin D1 in CD34+ bone marrow mononuclear cells (BMMNCs) of patients with…”
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Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities by Chen, Guibin, Zeng, Weihua, Miyazato, Akira, Billings, Eric, Maciejewski, Jaroslaw P., Kajigaya, Sachiko, Sloand, Elaine M., Young, Neal S.

“…Aneuploidy, especially monosomy 7 and trisomy 8, is a frequent cytogenetic abnormality in the myelodysplastic syndromes (MDSs). Patients with monosomy 7 and…”
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Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib by Yong, Agnes S.M., Keyvanfar, Keyvan, Hensel, Nancy, Eniafe, Rhoda, Savani, Bipin N., Berg, Maria, Lundqvist, Andreas, Adams, Sharon, Sloand, Elaine M., Goldman, John M., Childs, Richard, Barrett, A. John

“…Primitive quiescent CD34+ chronic myeloid leukemia (CML) cells are more biologically resistant to tyrosine kinase inhibitors than their cycling counterparts;…”
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