Search Results - "SLEBOS, R. J. C"

Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma by Slebos, R J C, Li, M, Vadivelu, S, Burkey, B B, Netterville, J L, Sinard, R, Gilbert, J, Murphy, B, Chung, C H, Shyr, Y, Yarbrough, W G

“…Carcinogen exposure from tobacco smoking is the major cause of upper aerodigestive tract cancer, yet heavy smokers only have about a 10% life-time risk of…”
Get full text

Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations by Entius, M M, Westerman, A M, Giardiello, F M, van Velthuysen, M-L F, Polak, M M, Slebos, R J C, Wilson, J H P, Hamilton, S R, Offerhaus, G J A

“…Background—Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and…”
Get full text

The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma evidence of distinct molecular genetic pathways by LAX, S. F, KENDALL, B, TASHIRO, H, SLEBOS, R. J. C, ELLENSON, L. H

“…The two most common types of uterine endometrial carcinoma, endometrioid (UEC) and serous (USC), differ in their histopathologic appearance and biologic…”
Get full text

Clinical significance of ras oncogene activation in human lung cancer by RODENHUIS, S, SLEBOS, R. J. C

“…Activation of ras oncogenes is commonly found in human neoplasms. We have investigated 280 human lung cancer specimens for ras activation, including 38 that…”
Get full text

Expression of the second calcitonin/calcitonin gene-related peptide gene in Ewing sarcoma cell lines by Höppener, J W, Steenbergh, P H, Slebos, R J, Visser, A, Lips, C J, Jansz, H S, Bechet, J M, Lenoir, G M, Born, W, Haller-Brem, S

“…The existence of two closely related calcitonin (CT)/CT gene-related peptide (CGRP) genes has been recognized in rat and man. In man, expression of the CALC-I…”
Get more information

K-ras oncogene activation in atypical alveolar hyperplasias of the human lung by WESTRA, W. H, BAAS, I. O, HRUBAN, R. H, ASKIN, F. B, WILSON, K, OFFERHAUS, G. J. A, SLEBOS, R. J. C

“…Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early…”
Get full text

P193 Short-term Culture and In Vivo Modeling of Primary Head and Neck Squamous Cell Carcinoma by Whigham, A. S, Netterville, J. L, Burkey, B. B, Sinard, R. J, Chung, C. H, Slebos, R. J. C, Yarbrough, W. G

Get full text

K-ras Oncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung by Slebos, Robert J.C, Kibbelaar, Robert E, Dalesio, Otilia, Kooistra, Anko, Stam, Jacob, Meijer, Chris J.L.M, Wagenaar, Sjoerd S, Vanderschueren, Ronald G.J.R.A, van Zandwijk, Nico, Mooi, Wolter J, Bos, Johannes L, Rodenhuis, Sjoerd

“…THE concept of oncogenes has revolutionized our understanding of cancer, but there have been disappointingly few situations in which the detection of activated…”
Get full text

K‐ras mutations in the duodenal fluid of patients with pancreatic carcinoma by Wilentz, Robb E., Chung, Christine H., Sturm, Patrick D. J., Musler, Alex, Sohn, Taylor A., Offerhaus, G. Johan A., Yeo, Charles J., Hruban, Ralph H., Slebos, Robbert J. C.

“…BACKGROUND Many patients with carcinoma of the pancreas die because their disease is not detected until late in its course. Methods that detect these cancers…”
Get full text

K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung by Westra, W H, Slebos, R J, Offerhaus, G J, Goodman, S N, Evers, S G, Kensler, T W, Askin, F B, Rodenhuis, S, Hruban, R H

“…Point mutations in codon 12 of the K-ras protooncogene occur more frequently in lung adenocarcinomas from smokers (30%) than they do in lung adenocarcinomas…”
Get more information

Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study by Rodenhuis, S, Boerrigter, L, Top, B, Slebos, R J, Mooi, W J, van't Veer, L, van Zandwijk, N

“…To determine whether the clinical course and the response to chemotherapy of patients with advanced adenocarcinoma of the lung depends on the presence or…”
Get more information

Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung by Slebos, R J, Hruban, R H, Dalesio, O, Mooi, W J, Offerhaus, G J, Rodenhuis, S

“…To investigate a possible relationship between the exposure to tobacco smoke and the presence of ras point mutations, we examined lung adenocarcinoma samples…”
Get more information

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung by RODENHUIS, S, SLEBOS, R. J. C, BOOT, A. J. M, EVERS, S. G, MOOI, W. J, WAGENAAR, S. S, VAN BODEGOM, P. C, BOS, J. L

“…47 tumor samples, 45 of which were obtained at thoracotomy for non-small cell lung cancer were examined for mutational activation of the oncogenes H-ras,…”
Get full text

p53 alterations in atypical alveolar hyperplasia of the human lung by Slebos, Robbert J.C, Baas, Inge O, Clement, Marjon J, Offerhaus, G.Johan A, Askin, Fredric B, Hruban, Ralph H, Westra, William H

“…Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early…”
Get full text

Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement by SLEBOS, R. J. C, RESNICK, M. A, TAYLOR, J. A

“…Inactivation of the p53 tumor suppressor gene is a common finding in human cancer. In most cases, inactivation is due to a point mutation in the gene, but…”
Get full text

Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking by Westra, W H, Offerhaus, G J, Goodman, S N, Slebos, R J, Polak, M, Baas, I O, Rodenhuis, S, Hruban, R H

“…Mutations in the p53 tumor suppressor gene are frequently observed in primary lung adenocarcinomas, suggesting that these mutations are critical events in the…”
Get more information

Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver by Oudejans, J J, Slebos, R J, Zoetmulder, F A, Mooi, W J, Rodenhuis, S

“…To study the possible role of ras oncogene activation in the dissemination of colon cancer, we determined point mutations in codons 12, 13 and 61 in K- and…”
Get more information

Multiple hyperplastic polyps in the stomach: Evidence for clonality and neoplastic potential by Dijkhuizen, SM, Entius, MM, Clement, MJ, Polak, MM, Van den Berg, FM, Craanen, ME, Slebos, RJ, Offerhaus, GJ

“…The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This…”
Get full text

Clinical significance of K-ras oncogene activation in ampullary neoplasms by Chung, C H, Wilentz, R E, Polak, M M, Ramsoekh, T B, Noorduyn, L A, Gouma, D J, Huibregtse, K, Offerhaus, G J, Slebos, R J

“…AIMS: To investigate the prevalence of K-ras codon 12 point mutations in ampullary neoplasms, to explore their clinical usefulness, and to test whether the…”
Get full text

POTENTIAL FALSE-POSITIVE RESULTS WITH ANTIGEN ENHANCEMENT FOR IMMUNOHISTOCHEMISTRY OF THE p53 GENE PRODUCT IN COLORECTAL NEOPLASMS by BAAS, INGE O., VAN DEN BERG, FRANK M., MULDER, JAN-WILLEM R., CLEMENT, MARJON J., SLEBOS, ROBBERT J. C., HAMILTON, STANLEY R., OFFERHAUS, G. JOHAN A.

“…Aberrant crypt foci (ACF) are putative precursor lesions of colon cancer, recently identified on the methylene blue‐stained mucosal surface of human colon. No…”
Get full text