Search Results - "SLATTER, J. G."

Pharmacokinetics, Metabolism, and Excretion of Linezolid following an Oral Dose of [14C]Linezolid to Healthy Human Subjects by SLATTER, J. G, STALKER, D. J, STRYD, R. P, PENG, G. W, SHOBE, E. M, FEENSTRA, K. L, WELSHMAN, I. R, BRUSS, J. B, SAMS, J. P, JOHNSON, M. G, SANDERS, P. E, HAUER, M. J, FAGERNESS, P. E

“…Linezolid (Zyvox), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections, including…”
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Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition by Bleasby, K., Castle, J. C., Roberts, C. J., Cheng, C., Bailey, W. J., Sina, J. F., Kulkarni, A. V., Hafey, M. J., Evers, R., Johnson, J. M., Ulrich, R. G., Slatter, J. G.

“…Carrier-mediated transporters play a critical role in xenobiotic disposition and transporter research is complicated by species differences and their selective…”
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Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog by Slatter, J. G., Adams, L. A., Bush, E. C., Chiba, K., Daley-Yates, P. T., Feenstra, K. L., Koike, S., Ozawa, N., Peng, G. W., Sams, J. P., Schuette, M. R., Yamazaki, S.

“…1. Linezolid (ZYVOX™), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections. 2. The aim…”
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Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements by Foti, R. S., Dickmann, L. J., Davis, J. A., Greene, R. J., Hill, J. J., Howard, M. L., Pearson, J. T., Rock, D. A., Tay, J. C., Wahlstrom, J. L., Slatter, J. G.

“…Usnic acid is a component of nutritional supplements promoted for weight loss that have been associated with liver-related adverse events including mild…”
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Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer Patients by SLATTER, J. G, SCHAAF, L. J, MILLER, L. L, BAKER, D. S, PESHECK, C. V, LORD, R. S, SAMS, J. P, FEENSTRA, K. L, JOHNSON, M. G, BOMBARDT, P. A, CATHCART, K. S, VERBURG, M. T, PEARSON, L. K, COMPTON, L. D

“…This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m 2 (100 μCi) [ 14 C]CPT-11 in eight…”
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Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome by Slatter, J. G., Templeton, I. E., Castle, J. C., Kulkarni, A., Rushmore, T. H., Richards, K., He, Y., Dai, X., Cheng, O. J., Caguyong, M., Ulrich, R. G.

“…Oligonucleotide microarrays were used to study the variability of pharmacokinetics and drug metabolism (PKDM)-related gene expression in 75 normal human…”
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Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions by SLATTER, J. G, SU, P, SAMS, J. P, SCHAAF, L. J, WIENKERS, L. C

“…Human hepatic microsomes were used to investigate the carboxylesterase-mediated bioactivation of CPT-11 to the active metabolite, SN-38. SN-38 formation…”
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Venous irritation, pharmacokinetics, and tissue distribution of tirilazad in rats following intravenous administration of a novel supersaturated submicron lipid emulsion by YOUMIN WANG, MESFIN, G.-M, RODRIGUEZ, C. A, SLATTER, J. G, SCHUETTE, M. R, CORY, A. L, HIGGINS, M. J

“…To compare the venous irritation, pharmacokinetics, and tissue distribution of tirilazad in rats after intravenous administration of a submicron lipid emulsion…”
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Metabolism of the bisphosphonate ester U-91502 in rats by Slatter, J G, Feenstra, K L, Hauer, M J, Kloosterman, D A, Parton, A H, Sanders, P E, Scott, G, Speed, W

“…The major metabolites of the bisphosphonate ester U-91502 were isolated from the bile and urine of male Sprague-Dawley rats and identified by NMR and MS. Bile…”
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Biotransformation of lifibrol (U-83860) to mixed glyceride metabolites by rat and human hepatocytes in primary culture by Sun, E L, Feenstra, K L, Bell, F P, Sanders, P E, Slatter, J G, Ulrich, R G

“…Lifibrol (U-83860), K12.148) is a lipid-lowering drug that has the potential to accumulate in the liver and induce hepatic peroxisome proliferation. To…”
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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities by Slatter, J. Greg, Rashed, Mohamed S, Pearson, Paul G, Han, Deog Hwa, Baillie, Thomas A

“…S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry…”
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Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo by Slatter, J. G., Cheng, O., Cornwell, P. D., De Souza, A., Rockett, J., Rushmore, T., Hartley, D., Evers, R., He, Y., Dai, X., Hu, R., Caguyong, M., Roberts, C. J., Castle, J., Ulrich, R. G.

“…To examine species-specific aspects of the induction of absorption, distribution, metabolism and excretion (ADME)-related genes, we used 25 000 gene…”
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Metabolism of a bisphosphonate ester (PNU-91638) in rat by SLATTER, J. G., FEENSTRA, K. L., HAUER, M. J., SANDERS, P. E., VRBANAC, J. J., SCOTT, G., SPEED, W.

“…1. Metabolites of the cyclic bisphosphonate ester, 4-[2,2′-bis-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)] butanoyl-3-fluoro-benzene (PNU-91638) in bile or…”
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S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate by Pearson, P G, Slatter, J G, Rashed, M S, Han, D H, Grillo, M P, Baillie, T A

“…S-(N-methylcarbamoyl)glutathione, a chemically-reactive glutathione conjugate, has been isolated from the bile of rats administered methyl isocyanate and…”
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Pharmacokinetics and metabolism of the novel anticonvulsant agent N-(2,6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide (D2624) in rats and humans by MARTIN, S. W, BISHOP, F. E, DESCOMBE, J.-J, PICARD, M, BAILLIE, T. A, LEVY, R. H, KERR, B. M, MOOR, M, MOORE, M, SHEFFELS, P, RASHED, M, SLATTER, J. G, BERTHON-CEDILLE, L, LEPAGE, F

“…N-(2,6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide (D2624) belongs to a new series of experimental anticonvulsants related to lidocaine. This study was…”
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Absorption, Distribution, Metabolism, and Excretion of Atevirdine in the Rat by CHANG, M, SOOD, V. K, WILSON, G. J, KLOOSTERMAN, D. A, SANDERS, P. E, SCHUETTE, M. R, JUDY, R. W, VOORMAN, R. L, MAIO, S. M, SLATTER, J. G

“…Atevirdine mesylate (U-87201E) is a highly specific nonnucleoside inhibitor of human immunodeficiency virus type 1 reverse transcriptase. The absorption,…”
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The Pharmacokinetics of Linezolid Are Not Affected by Concomitant Intake of the Antioxidant Vitamins C and E by Gordi, Toufigh, Tan, Lai Hock, Hong, Catherine, Hopkinsy, Nancy J., Francom, Steven F., Slatter, J. Greg, Antal, Edward J.

“…In vitro metabolism experiments have suggested a possible role for endogenous reactive oxygen species (ROS) in the in vivo clearance of linezolid, a synthetic…”
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Methadone metabolism in the rat in vivo: identification of a novel formamide metabolite by Abbott, F S, Slatter, J G, Burton, R, Kang, G I

“…Deuterium-labelled methadone and metabolites were used for the g.l.c.-mass spectrometry detection and identification of biliary conjugated methadone…”
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Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate by Pearson, Paul G, Slatter, J. Greg, Rashed, Mohamed S, Han, Deog Hwa, Baillie, Thomas A

“…The reactivity toward peptides and proteins of S-(N-methylcarbamoyl)glutathione (SMG), the glutathione conjugate of methyl isocyanate, and the corresponding…”
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Studies on the metabolic fate of caracemide, an experimental antitumor agent, in the rat. Evidence for the release of methyl isocyanate in vivo by Slatter, J. Greg, Davis, Margaret R, Han, Deog Hwa, Pearson, Paul G, Baillie, Thomas A

“…Following administration to rats of a single ip dose (6.6 mg kg-1) of the investigational antitumor agent caracemide…”
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