Search Results - "SLAABY, RITA"

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718 by Andersen, Mie, Nørgaard-Pedersen, Dorte, Brandt, Jakob, Pettersson, Ingrid, Slaaby, Rita

“…Alanine scan of insulin receptor (IR)-B exon 11 and site-directed mutagenesis of amino acid 718 in human IR-A and IR-B were performed. Ligand affinities to…”
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Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes by Lyhne, Mille K., Vegge, Andreas, Povlsen, Gro Klitgaard, Slaaby, Rita, Kildegaard, Jonas, Pedersen-Bjergaard, Ulrik, Olsen, Lisbeth H.

“…The potentially fatal cardiovascular effects of hypoglycaemia are not well understood and large animal models of the counter-regulatory responses and…”
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Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo by Hvid, Henning, Glendorf, Tine, Brandt, Jakob, Slaaby, Rita, Lützen, Anne, Kristensen, Kim, Hansen, Bo F.

“…Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased the incidence…”
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A novel high-affinity peptide antagonist to the insulin receptor by Schäffer, Lauge, Brand, Christian L., Hansen, Bo F., Ribel, Ulla, Shaw, Allan C., Slaaby, Rita, Sturis, Jeppe

“…In this publication we describe a peptide insulin receptor antagonist, S661, which is a single chain peptide of 43 amino acids. The affinity of S661 for the…”
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Hybrid Receptors Formed by Insulin Receptor (IR) and Insulin-like Growth Factor I Receptor (IGF-IR) Have Low Insulin and High IGF-1 Affinity Irrespective of the IR Splice Variant by Slaaby, Rita, Schäffer, Lauge, Lautrup-Larsen, Inger, Andersen, Asser Sloth, Shaw, Allan Christian, Mathiasen, Ida Stenfeldt, Brandt, Jakob

“…Insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) are both from the same subgroup of receptor tyrosine kinases that exist as covalently…”
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Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10 by Hansen, Bo F, Glendorf, Tine, Hegelund, Anne C, Lundby, Anders, Lützen, Anne, Slaaby, Rita, Stidsen, Carsten Enggaard

“…There is controversy with respect to molecular characteristics of insulin analogues. We report a series of experiments forming a comprehensive characterisation…”
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Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin by Slaaby, Rita

“…This novel method enables specific measurement of the activation of hybrid receptors formed between the Insulin Receptor (IR) and the Insulin-like Growth…”
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Ddb1 controls genome stability and meiosis in fission yeast by Holmberg, Christian, Fleck, Oliver, Hansen, Heidi A, Liu, Cong, Slaaby, Rita, Carr, Antony M, Nielsen, Olaf

“…The human UV-damaged DNA-binding protein Ddb1 associates with cullin 4 ubiquitin ligases implicated in nucleotide excision repair (NER). These complexes also…”
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X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution by Seetharaman, J., Kanigsberg, Amit, Slaaby, Rita, Leffler, Hakon, Barondes, Samuel H., Rini, James M.

“…Galectins are a family of lectins which share similar carbohydrate recognition domains (CRDs) and affinity for small β-galactosides, but which show significant…”
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A BRET assay for monitoring insulin receptor interactions and ligand pharmacology by Kulahin, Nikolaj, Sanni, Samra J., Slaaby, Rita, Nøhr, Jane, Gammeltoft, Steen, Hansen, Jakob Lerche, Jorgensen, Rasmus

“…The insulin receptor (IR) belongs to the receptor tyrosine kinase super family and plays an important role in glucose homeostasis. The receptor interacts with…”
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PLD2 Complexes with the EGF Receptor and Undergoes Tyrosine Phosphorylation at a Single Site upon Agonist Stimulation by Slaaby, R, Jensen, T, Hansen, H S, Frohman, M A, Seedorf, K

“…Mammalian phospholipase D (PLD) activity becomes up-regulated when cells are stimulated by a variety of hormones, growth factors, and other extracellular…”
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Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling by Nielsen, Jeppe, Brandt, Jakob, Boesen, Thomas, Hummelshøj, Tina, Slaaby, Rita, Schluckebier, Gerd, Nissen, Poul

“…[Display omitted] •Cryo-EM structures of full-length insulin receptor dimer with 2 or 3 insulin bound at sites 1, 2 and 2′•Asymmetric receptor complexes are…”
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802-P: Beneficial Effects of a Functionally Selective Insulin on Vascular Function and Liver Triglycerides by OLSEN, GRITH S., PEDERSEN, THOMAS A., SLAABY, RITA, HANSEN, BO F., GLENDORF, TINE, DEMOZAY, DAMIEN, HVID, HENNING, NISHIMURA, ERICA, BRANDT, JAKOB, POVLEN, GRO

“…Selective insulin resistance, where insulin's ability to lower blood glucose via the Akt signaling pathway gradually decreases while retaining its…”
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Glucose-sensitive insulin with attenuation of hypoglycaemia by Hoeg-Jensen, Thomas, Kruse, Thomas, Brand, Christian L., Sturis, Jeppe, Fledelius, Christian, Nielsen, Peter K., Nishimura, Erica, Madsen, Alice R., Lykke, Lennart, Halskov, Kim S., Koščová, Simona, Kotek, Vladislav, Davis, Anthony P., Tromans, Robert A., Tomsett, Michael, Peñuelas-Haro, Guillem, Leonard, Daniel J., Orchard, Michael G., Chapman, Andy, Invernizzi, Gaetano, Johansson, Eva, Granata, Daniele, Hansen, Bo F., Pedersen, Thomas A., Kildegaard, Jonas, Pedersen, Karen-Margrethe, Refsgaard, Hanne H. F., Alifrangis, Lene, Fels, Johannes J., Neutzsky-Wulff, Anita V., Sauerberg, Per, Slaaby, Rita

“…The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes 1 , 2 . Insulin doses must…”
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Activation of insulin receptors and IGF-1 receptors in COLO-205 colon cancer xenografts by insulin and insulin analogue X10 does not enhance growth under normo- or hypoglycaemic conditions by Hvid, Henning, Jørgensen, Mikkel S., Blume, Niels, Slaaby, Rita, Lützen, Anne, Hansen, Bo F.

“…Aims/hypothesis Recent studies with normal rats and mouse allograft models have reported that insulin and insulin analogues do not activate the IGF-1 receptor…”
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Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries by Mughal, Romana S, Bridge, Katherine, Buza, Irma, Slaaby, Rita, Worm, Jesper, Klitgaard-Povlsen, Gro, Hvid, Henning, Schiødt, Marianne, Cubbon, Richard, Yuldasheva, Nadira, Skromna, Anna, Makava, Natallia, Skytte-Olsen, Grith, Kearney, Mark T

“…Insulin and insulin-like growth factor-1 stimulate specific responses in arteries, which may be disrupted by diet-induced obesity. We examined (1) temporal…”
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Cross-species reactive monoclonal antibodies against the extracellular domains of the insulin receptor and IGF1 receptor by Ørstrup, Laura Hvidsten, Slaaby, Rita, Rasch, Morten Grønbech, Rasmussen, Nicolaj, Lund, Søren, Brandt, Jakob, Schluckebier, Gerd, Wang, Zhe, Lützen, Anne, Pedersen, Thomas Åskov, Hvid, Henning, Hansen, Bo Falck, Blume, Niels

“…Translation across species of immunoassay results is often challenging due to the lack of cross-species reactivity of antibodies. In order to investigate the…”
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IGF-I binding to the IGF-I receptor is affected by contaminants in commercial BSA: The contaminants are proteins with IGF-I binding properties by Slaaby, Rita, Andersen, Asser Sloth, Brandt, Jakob

“…Abstract Objective To determine whether different albumins have an effect on IGF-I binding assays. Methods We have studied the effect of five different…”
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Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade by Slaaby, R, Du, G, Altshuller, Y M, Frohman, M A, Seedorf, K

“…Phospholipase D (PLD)1 is quiescent in vitro and in vivo until stimulated by classical protein kinase C (PKC) isoforms, ADP-ribosylation factor or Rho family…”
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Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase Cγ and protein kinase Cα signalling cascade by SLAABY, Rita, DU, Guangwei, ALTSHULLER, Yelena M., FROHMAN, Michael A., SEEDORF, Klaus

“…Phospholipase D (PLD)1 is quiescent in vitro and in vivo until stimulated by classical protein kinase C (PKC) isoforms, ADP-ribosylation factor or Rho family…”
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